Vet Diagnostics

Sainte-Foy-lès-Lyon, France

Vet Diagnostics

Sainte-Foy-lès-Lyon, France
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Quintard B.,Parc Zoologique et Botanique de Mulhouse | Greunz E.M.,Parc Zoologique et de Loisirs de Thoiry | Lefaux B.,Parc Zoologique et Botanique de Mulhouse | Lemberger K.,Vet Diagnostics | Leclerc A.,Parc Zoologique et de Loisirs de Thoiry
Journal of Zoo and Wildlife Medicine | Year: 2017

Squamous cell carcinoma (SCC) is well documented in snow leopards (Uncia uncia) and most common locations are oral, facial, or pedal. These two cases illustrate an unusual auricular presentation, which is more often reported in white domestic cats. The animals were aged and presented clinical signs of otitis such as head shaking and ear scratching. Clinical examinations showed auricular canal masses with chronic purulent otitis. In both cases, clinical deterioration led to euthanasia and histology of the ear canal was consistent with SCC and showed numerous vascular emboli. These cases illustrate an unreported aggressive localization for SCC in snow leopards, which should be included in the differential diagnosis of otitis in this species. Auricular SCC may be underdiagnosed as the ear canal is infrequently sampled for histopathology. This auricular localization should be considered when metastases are found upon necropsy without internal primary tumor. © Copyright 2017 by American Association of Zoo Veterinarians.


Lamglait B.,Reserve Africaine de Sigean | Joris A.,Reserve Africaine de Sigean | Romey A.,French National Institute for Agricultural Research | Bakkali-Kassimi L.,French National Institute for Agricultural Research | Lemberger K.,Vet Diagnostics
Journal of Zoo and Wildlife Medicine | Year: 2015

A fatal case of encephalomyocarditis virus (EMCV) involving an African elephant (Loxodonta africana) occurred in November 2013 at the Réserve Africaine de Sigean, France. An adult female was found dead without any preliminary symptoms. Gross pathologic changes consisted of petechiae and hemorrhages on mucosae and internal organs, abundant transudate in the abdominal and pericardial cavities, and myocarditis. Histopathologic examination showed extensive degeneration and necrosis of ventricular cardiomyocytes with concurrent lymphoplasmocytic and eosinophilic infiltrate. An EMCV was isolated from several organs and considered the causative agent of the myocarditis. The same strain of virus was also isolated in rodents captured on zoo premises and considered to be the reservoir of the virus. To the authors' knowledge, this is the first EMCV case in a captive African elephant in Europe. © 2015 American Association of Zoo Veterinarians.


Vittecoq M.,IRD Montpellier | Ducasse H.,IRD Montpellier | Arnal A.,IRD Montpellier | Moller A.P.,University Paris - Sud | And 20 more authors.
Animal Behaviour | Year: 2015

Scientists are increasingly coming to realize that oncogenic phenomena are both frequent and detrimental for animals, and must therefore be taken into account when studying the biology of wildlife species and ecosystem functioning. Here, we argue that several behaviours that are routine in an individual's life can be associated with cancer risks, or conversely prevent/cure malignancies and/or alleviate their detrimental consequences for fitness. Although such behaviours are theoretically expected to be targets for natural selection, little attention has been devoted to explore how they influence animal behaviour. This essay provides a summary of these issues as well as an overview of the possibilities offered by this research topic, including possible applications for cancer prevention and treatments in humans. © 2014 The Association for the Study of Animal Behaviour.


Lamglait B.,Reserve Africaine de Sigean | Lemberger K.,Vet Diagnostics
Journal of Zoo and Wildlife Medicine | Year: 2017

This article reports five cases of colonic adenocarcinomas in a family group of captive Amur rat snake (Elaphe schrenckii) from the Réserve Africaine de Sigean, France. This tumor was detected in three females and two males, all adults, and accounted for 16% of causes of death of adults of this species at this institution from 1986 to 2013. Grossly, mild to marked thickening of the intestinal wall cranially to the cloaca was found in four cases; tan to yellow firm masses were noted in the distal intestinal wall in the other case. Microscopically, neoplasms were characterized by infiltrating, poorly circumscribed, and unencapsulated nests of epithelial cells. Marked anisokaryosis and anisocytosis were seen in all neoplasms. The etiology of the neoplasms was not determined, but the familial clustering suggests a common etiologic factor. © Copyright 2017 by American Association of Zoo Veterinarians.


Greunz E.M.,Parc Zoologique et de Loisirs de Thoiry | Simon M.,Parc Zoologique et de Loisirs de Thoiry | Lemberger K.,Vet Diagnostics | Galateanu G.,Leibniz Institute for Zoo and Wildlife Research | And 2 more authors.
Journal of Zoo and Wildlife Medicine | Year: 2016

The current report describes the temporary regression, due to intensive symptomatic treatment, of ulcerative skin lesions caused by squamous cell carcinoma in a white rhinoceros. A captive, 40-yr-old southern white rhinoceros (Ceratotherium simum simum) developed profound, ulcerative skin lesions on the pads of both hind feet. At the peak of the disease, at least one quarter of the pads was affected. A diagnosis of squamous cell carcinoma was made via biopsy. Treatment included anti-inflammatory drugs, antibiotics, and local care. The lesions regressed on both feet until they seemed clinically healed. It was presumed that long-term, anti-inflammatory treatment and local bandaging had induced the temporary regression of the lesions. Two years later, however, a small ulcerative lesion reappeared on one pad and post mortem examination confirmed that the carcinoma was also histologically present in the clinically intact tissue. No metastasis was found and computed tomography showed normal digital bones. © Copyright 2016 by American Association of Zoo Veterinarians.


Scala C.,French Natural History Museum | Ortiz K.,French Natural History Museum | Nicolier A.,Vet Diagnostics | Briend-Marchal A.,Laboratoire Vebiotel
Journal of Zoo and Wildlife Medicine | Year: 2013

A captive 3-yr-old male dhole (Cuon alpinus) was presented for poor body condition. Pancytopenia concurrent with bone marrow aspiration that revealed severe medullary infiltration by a population of initially small lymphocytes was diagnostic of an aleukemic chronic lymphocytic leukemia. Chemotherapy was initiated, but euthanasia was elected after the animal's rapid deteriorating condition and sudden lymphoid organs hypertrophy several days after initial presentation. Histology revealed lymphoid organs and bone marrow infiltration by highly proliferating immature lymphocytes compatible with a blast crisis. On immunohistochemistry, neoplastic cells appeared CD3 positive, confirming a T lymphoid origin. This is the first report of a lymphocytic leukemia in a wild canid species. Copyright 2013 by American Association of Zoo Veterinarians.


Scala C.,French Natural History Museum | Scala C.,University of Montréal | Ortiz K.,French Natural History Museum | Catinaud J.,French Natural History Museum | Lemberger K.,Vet Diagnostics
Journal of Zoo and Wildlife Medicine | Year: 2014

Hemangiosarcoma, hemangioma, transitional cell carcinoma, and chronic cystitis were diagnosed in the urinary bladder of six captive fallow deer (Dama dama). Hematuria and thin body condition were observed in the advanced cases. These findings were compatible with chronic enzootic hematuria and were suspected to have been induced by chronic ingestion of bracken fern (Pteridium aquilinum) present on the premises. These lesions were similar to those described in bovine enzootic hematuria in cattle. Hemangiosarcoma metastases, hydronephrosis, and renal carcinoma were also associated in some cases. This is the first report of hemangioma, hemangiosarcoma, transitional cell carcinoma, and renal carcinoma of the urinary bladder in fallow deer and the first indication of bracken fern intoxication in deer. © 2014 by American Association of Zoo Veterinarians.


Scala C.,French Natural History Museum | Scala C.,University of Montréal | Langlois I.,University of Montréal | Lemberger K.,Vet Diagnostics
Journal of Avian Medicine and Surgery | Year: 2015

A captive juvenile little bustard (Tetrax tetrax) was presented for acute onset of right head tilt and right circling. The bird failed to respond to supportive care and systemic antibiotic therapy. A bilateral granulomatous and fibrinoheterophilic otitis interna due to Pseudomonas aeruginosa was diagnosed postmortem by histopathologic examination and bacterial culture. In bustards, Pseudomonas species have been documented in the normal bacterial flora of the oropharynx and are frequently reported in upper respiratory tract infections. This is the first report of a peripheral vestibular syndrome due to P aeruginosa otitis interna in a bustard species. Pseudomonas aeruginosa should be included as a possible cause of otitis and peripheral vestibular syndrome in bustards. © 2015 by the Association of Avian Veterinarians.


Umhang G.,National Reference Laboratory for sp | Lahoreau J.,Parc Animalier de Sainte Croix | Nicolier A.,Vet Diagnostics | Boue F.,National Reference Laboratory for sp
Parasitology International | Year: 2013

Echinococcus multilocularis is a tapeworm responsible in its larval stage for alveolar echinococcosis, a disease which is lethal when left untreated. Multivesiculated parasitic lesions in the liver were diagnosed at necropsy in a captive-born nutria (Myocastor coypus) and in a ring-tailed lemur (Lemur catta) which had been in a French zoo for 16. months. Molecular analyses confirmed the diagnosis of E. multilocularis obtained by histological analyses. These were the first cases of infection by E. multilocularis reported in lemurs in Europe, and the first case in nutria in European enclosures. Lemurs are confirmed to be particularly sensitive to E. multilocularis with a massive infection. In both cases, the infection appears to have been contracted in the zoo indirectly via environmental contamination by feces from roaming foxes. Due to the large endemic area for E. multilocularis, the increasing prevalence in foxes in France, and an increase in awareness of the disease, other cases of infection in captive animals will probably be recorded in France in the coming years. © 2013 Elsevier Ireland Ltd.


Libert C.,Parc Zoologique de Montpellier | Jouet D.,University of Reims Champagne Ardenne | Ferte H.,University of Reims Champagne Ardenne | Lemberger K.,Vet Diagnostics
Journal of Zoo and Wildlife Medicine | Year: 2012

Postmortem examination of a 4-mo-old captive-born blue-crowned motmot (Momotus momota) at the Montpellier Zoo in France revealed the presence of air sac flukes. Circumvitellatrema momota (Digenea: Cyclocoelidae) was suspected and confirmed by molecular genetic analysis. Digenean metacercariae were extracted from an invasive species of terrestrial snail, the conical periwinkle, Subulina striatella. Molecular genetic analysis determined that these metacercariae were also C. momota, confirming that all the stages of this parasite's life cycle were present and that birds were likely becoming infected by eating these infected snails. It is likely that this trematode was imported into the greenhouse with a wild-caught motmot. The conical periwinkle snail appears to have been imported into the zoo with the plants in 2007 when the greenhouse was built. Treatments, which have been disappointing, are discussed, as well as preventive measures to avoid dissemination of the parasite into other bird collections in Europe. Copyright © 2012 by American Association of Zoo Veterinarians.

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