Kalamazoo, MI, United States
Kalamazoo, MI, United States

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Patent
Vestaron Corp | Date: 2013-02-06

The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic procedures, intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects using the compounds.


Patent
Vestaron Corp | Date: 2014-03-07

Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.


Patent
Vestaron Corp | Date: 2013-02-15

Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.


Patent
Vestaron Corp | Date: 2011-07-20

The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic procedures, intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects using the compounds.


Patent
Vestaron Corp | Date: 2016-04-28

Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.


Patent
Vestaron Corp | Date: 2016-09-14

Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.


Patent
Vestaron Corp | Date: 2012-06-20

Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.


Grant
Agency: Department of Agriculture | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 95.58K | Year: 2012

This Small Business Innovation Research Phase I project proposes to enhance the delivery of a novel class of small insecticidal peptides. Insect damage to crops threatens global food security and as a result farmers grow millions of acres of crops with insecticides expressed as transgenes, and protect millions more acres with spray-on pesticides. The inevitable evolution of insect resistance to insecticides occurs despite rotating mode-of-action chemicals and proper transgenic plant refuge stewardship. Research into safe new insecticides is needed now to protect our future crop production. This project proposes to develop an enhanced delivery of a new class of insecticidal peptides from the Blue Mountains funnel-web spider. Individual peptides have been identified and characterized from a venom screen. Their mode of action is insect-specific and interferes with various ion channels in the central nervous system (CNS). Toxicity occurs when insect pests ingest the peptide and it passes through the gut wall, into the hemolymph and into the CNS. Vestaron Corporation is developing spray-on pesticide products from these peptides are looking to enhance their activity further by aiding in their delivery to the CNS. This proposed research involves combining Vestaron's peptides to one of three classes of proteins that will aid in crossing the gut wall. The tests will be done in vitro by spraying the purified proteins onto leaf disks and running insect mortality assays and screening insect hemolymph for elevated levels of the insecticidal peptide. It is anticipated that one or many of the combinations will generate a technology that enhances delivery of the peptide and results in increased efficacy. Completion of this Phase I project will allow a focused transition to in planta assays in Phase II where the spray-on technology will be manufactured as a transgene and the proof of concept will generate a research partnership within the agriculture industry to develop a new plant incorporated protectant (PIP). The improvements from Phase I will also be captured by Vestaron's own spray-on product pipeline resulting in this improvement being available to both the PIP and spray-on markets in the future.


Grant
Agency: Department of Agriculture | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 99.98K | Year: 2013

Global food production from plants is at risk from insect pests. To protect their crops farmers spend a great deal of money on insecticides. For example, US farmers spent $1.2 billion in 2009 on insecticides for crop protection, which resulted in $22.9 billion of additional income due to crops saved from insect damage. However, the number of insecticides available to farmers is declining due to deregistration of some products for health and safety reasons, and due to the evolution of insects with insecticide resistance. It has been estimated there are over 500 insect pest species resistant to a total of over 300 insecticide compounds. Even the widely used bioinsecticide proteins from Bacillus thuringiensis (Cry1Ac, Cry1Ab, and Cry1F toxins) are now compromised by the documented evolution of insect resistance in many parts of the world. These B. thuringiensis proteins are used as Plant Incorporated Protectants (PIP's) in vast acreages of GMO crops that comprise a very large fraction of global agricultural production. The most effective strategy to keep them from becoming obsolete requires the incorporation of a "stack" of transgenes, encoding diverse protein-based insecticides with novel modes of action, to reduce the odds of insects evolving simultaneous resistance to all the expressed proteins. In summary, new, safe insecticides are needed to protect future food production, all the more so in view of the anticipated rise of global population to ~10 Billion by 2050. This proposal will work to enhance the function of a novel class of protein-based insecticides to an economically viable level, such that they can either be used as transgenes (PIP's), for large scale agriculture, or as biodegradable spray-on products to protect any crop from insect pests. The research focuses on a rate-limiting step in the delivery of these insecticidal proteins to their sites of action: the uptake of the ingested proteins from the insect gut across the insect gut wall. The project will screen large libraries of variable protein sequences for a short peptide that acts to enhance the uptake of attached "cargo" molecules from the insect gut into the insect hemolymph (~insect bloodstream). This peptide will be used with Vestaron's portfolio of insecticidal proteins to enhance their insecticidal activity and make a more economically viable insecticidal product.


New insecticidal proteins, nucleotides, peptides, their expression in plants, methods of producing the peptides, new processes, production techniques, new peptides, new formulations, and new organisms, a process which increases the insecticidal peptide production yield from yeast expression systems. The present invention is also related and discloses selected endotoxins we call cysteine rich insecticidal peptides (CRIPS) which are peptides derived from Bacillus thuringiensis (Bt) and their genes and endotoxins in combination with toxic peptides known as Inhibitor Cystine Knot (ICK) genes and peptides as well as with other types of insecticidal peptides such as trypsin modulating oostatic factor (TMOF) peptide sequences used in various formulations and combinations; of both genes and peptides, useful for the control of insects.

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