Peoria, AZ, United States
Peoria, AZ, United States

Time filter

Source Type

Stuckey M.I.,University of Western Ontario | Stuckey M.I.,Lawson Health Research Institute | Tulppo M.P.,Verve Medical | Kiviniemi A.M.,Verve Medical | And 2 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2014

Background: A number of cross-sectional studies have examined associations between heart rate variability and metabolic syndrome, but differences in study populations, data collection and analysis methodologies make synthesis difficult. The purpose of this study was to systematically review published primary research examining associations between heart rate variability and metabolic syndrome or its individual risk factors. Methods: A systematic literature search of PubMed and EMBASE was conducted to identify relevant articles published from January 1999 to December 2012. Studies were included if they examined associations between heart rate variability analysed by standard protocols and metabolic syndrome risk factors according to published definitions. All papers were scored with a modified Downs and Black instrument, and data were extracted. Results: Fourteen studies were included. Heart rate variability generally was reduced in women with metabolic syndrome compared to those without, while results in men were inconsistent. Time and frequency domain heart rate variability parameters were associated with individual metabolic syndrome risk factors, though sex differences exist. Only two studies considered nonlinear and Poincaré plot heart rate variability parameters, which were reduced in metabolic syndrome. Conclusions: Heart rate variability is altered differently in men and women with metabolic syndrome. Future studies should follow consistent heart rate variability analysis protocols and metabolic syndrome definitions and include more comprehensive analyses to investigate potential mechanisms. © 2014 John Wiley & Sons, Ltd.


Heuser R.R.,University of Arizona | Mhatre A.U.,Rush University Medical Center | Buelna T.J.,Verve Medical | Berci W.L.,Verve Medical | Hubbard B.S.,Verve Medical
EuroIntervention | Year: 2013

Aims: To evaluate in a preclinical model the utility of a monopolar electrode catheter delivering radiofrequency (RF) energy placed into the renal pelvis in order to treat resistant hypertension (RH). Methods and results: Sixteen female domestic swine weighing 60-65 kg underwent renal pelvic denervation via ureteral access. Three animals were euthanised immediately after delivery of RF energy; five animals were allowed to survive for seven days, six animals were allowed to survive for 14 days and two animals were allowed to survive for 30 days. Renal cortical norepinephrine levels were measured in all groups of animals. Histopathology of the treated zone was performed to confirm nerve damage. Renal cortical tissue was harvested for determination of tissue norepinephrine by HPLC. The kidneys were then profusion-fixed and harvested for histopathologic analysis. Mean reduction of norepinephrine levels was 60.4% compared to control. Histopathology confirmed nerve ablation in the treated zone. Conclusions: In this small, preclinical study, we introduce a new non-vascular system to treat resistant hypertension. If the current clinical experience confirms efficacy and safety, this approach may be one way to treat patients who cannot be treated with the standard percutaneous arterial devices. © Europa Digital & Publishing 2013. All rights reserved.


Patent
Verve Medical | Date: 2015-07-24

A target peripheral nerve is treated by providing a real-time fluorescent image of a tissue region where the target peripheral nerve has an enhanced appearance in the fluorescent image. A treatment element is advanced from an adjacent body lumen or cavity through the tissue region or externally aimed toward the peripheral nerve while viewing the fluorescent image, and the peripheral nerve is treated using the treatment element.


Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.


Patent
Verve Medical | Date: 2012-07-12

Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.


Patent
Verve Medical | Date: 2015-02-06

Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances to ablate a thin layer of tissue lining at least a portion of the renal pelvis to disrupt renal nerves within the tissue lining of the renal pelvis.


Trademark
Verve Medical | Date: 2013-03-19

Medical and surgical catheters; Medical device for accessing subcutaneous structures of the human body for the purpose of administering medical treatment; Medical devices, namely, surgical devices that facilitate the identification, separation or ablation of biologic tissues, the foregoing goods not consisting of lasers.


Trademark
Verve Medical | Date: 2013-03-19

Medical and surgical catheters; Medical device for accessing subcutaneous structures of the human body for the purpose of administering medical treatment; Medical devices, namely, surgical devices that facilitate the identification, separation or ablation of biologic tissues.


Trademark
Verve Medical | Date: 2013-03-19

Medical and surgical catheters; Medical device for accessing subcutaneous structures of the human body for the purpose of administering medical treatment; Medical devices, namely, surgical devices that facilitate the identification, separation or ablation of biologic tissues.


Loading Verve Medical collaborators
Loading Verve Medical collaborators