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Lima, Peru

Bussing A.,Witten/Herdecke University | Ostermann T.,Witten/Herdecke University | Ludtke R.,Veronica | Michalsen A.,Charite - Medical University of Berlin
Journal of Pain | Year: 2012

We searched databases for controlled clinical studies, and performed a meta-analysis on the effectiveness of yoga interventions on pain and associated disability. Five randomized studies reported single-blinding and had a higher methodological quality; 7 studies were randomized but not blinded and had moderate quality; and 4 nonrandomized studies had low quality. In 6 studies, yoga was used to treat patients with back pain; in 2 studies to treat rheumatoid arthritis; in 2 studies to treat patients with headache/migraine; and 6 studies enrolled individuals for other indications. All studies reported positive effects in favor of the yoga interventions. With respect to pain, a random effect meta-analysis estimated the overall treatment effect at SMD = -.74 (CI: -.97; -.52, P <.0001), and an overall treatment effect at SMD = -.79 (CI: -1.02; -.56, P <.0001) for pain-related disability. Despite some limitations, there is evidence that yoga may be useful for several pain-associated disorders. Moreover, there are hints that even short-term interventions might be effective. Nevertheless, large-scale further studies have to identify which patients may benefit from the respective interventions. Perspective: This meta-analysis suggests that yoga is a useful supplementary approach with moderate effect sizes on pain and associated disability. © 2012 by the American Pain Society. Source


Mathie R.T.,British Homeopathic Association | Clausen J.,Veronica
Homeopathy | Year: 2015

Background: Meta-analysis of randomised controlled trials (RCTs) of veterinary homeopathy has not previously been undertaken. For all medical conditions and species collectively, we tested the hypothesis that the outcome of homeopathic intervention (treatment and/or prophylaxis, individualised and/or non-individualised) is distinguishable from corresponding intervention using placebos. Methods: All facets of the review, including literature search strategy, study eligibility, data extraction and assessment of risk of bias, were described in an earlier paper. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specific domains of assessment. Effect size was reported as odds ratio (OR). A trial was judged free of vested interest if it was not funded by a homeopathic pharmacy. Meta-analysis was conducted using the random-effects model, with hypothesis-driven sensitivity analysis based on risk of bias. Results: Nine of 15 trials with extractable data displayed high risk of bias; low or unclear risk of bias was attributed to each of the remaining six trials, only two of which comprised reliable evidence without overt vested interest. For all N=15 trials, pooled OR=1.69 [95% confidence interval (CI), 1.12 to 2.56]; P=0.01. For the N=2 trials with suitably reliable evidence, pooled OR=2.62 [95% CI, 1.13 to 6.05]; P=0.02). Conclusions: Meta-analysis provides some very limited evidence that clinical intervention in animals using homeopathic medicines is distinguishable from corresponding intervention using placebos. The low number and quality of the trials hinders a more decisive conclusion. © 2014 The Faculty of Homeopathy. Source


Wimalawansa S.J.,Veronica
Journal of Clinical and Translational Endocrinology | Year: 2014

Health care workers need to embrace new concepts, collaborate with other care partners, and focus on cause-driven approaches [9,21] to overcome the obesity epidemic, and develop strategies to minimize obesity-associated stigma. It is irrational and in fact cost-prohibitive in the long term to treat each sign and complication of obesity. Thus, instead of waiting for complications to occur and then treat, cause-oriented approaches is necessary to early identification of reasons for weight gain in a given patient and focus attention on preventing obesity complications by preventing and/ or reversing such weight gain [9,21]. In addition, health care workers, insurance and third party payers, and the politicians need to listen to people, observe trends, and lead the change when appropriate so that physicians can continue what they do best: provide the best possible care for their patients, even under ever-increasing commitments and resource constraints. The stigma associated with obesity is a major barrier to accepting it as a disease by patients and thus to treatment; therefore, the stigma needs to be eliminated [26]. Stigma is also a major psychological and socioeconomic burden in the workplace and classrooms, affecting overweight and obese persons, and their families. The medical profession needs to lead by taking effective actions to overcome this societal stigma, in persons who are overweight or obese and those with other chronic diseases. © 2014 The Authors. Published by Elsevier Inc. All rights reserved. Source


Stock-Schroer B.,Veronica
Homeopathy | Year: 2015

Introduction: The aim of this study was to develop a criteria catalogue serving as a guideline for authors to improve quality of Reporting Experiments in Homeopathic Basic Research (REHBaR). Main focus was in the field of biochemical and biological experiments. So far, there was no guideline for scientists and authors available, unlike criteria catalogues common in clinical research. Methods: A Delphi Process was conducted among experts who published experimental work within the last five years in this field. The process included a total of five rounds, three rounds of adjusting and phrasing plus two consensus conferences. Results: A checklist of 23 items was achieved, augmented with detailed examples how to handle each item while compiling a publication. Background, objectives and possible hypotheses are necessary to be given in the part 'introduction'. The section 'materials and methods' is the most important part, where a detailed description of chosen controls, object of investigation, experimental setup, replication, parameters, intervention, allocation, blinding, and statistical methods is mandatory. In the 'results' section sufficient details on analysed data, descriptive as well as inferential are needed. Moreover, authors should discuss their results and interpret them in the context of current evidence. REHBaR was compiled for authors when preparing their manuscripts, and to be used by scientific journals in the reviewing process. Conclusions: Reporting experiments in basic research in homeopathy is an important issue to state the quality and validity of gained results. A guideline for REHBaR seemed to be the first step to come to a commitment what information is necessary to be given in a paper. More than that, the catalogue can serve as a statement what the standards in good basic research should be. © 2015 The Faculty of Homeopathy. Source


Mathie R.T.,British Homeopathic Association | Clausen J.,Veronica
Veterinary Record | Year: 2014

A systematic review of randomised controlled trials (RCTs) of veterinary homeopathy has not previously been undertaken. Using Cochrane methods, this review aims to assess risk of bias and to quantify the effect size of homeopathic intervention compared with placebo for each eligible peer-reviewed trial. Judgement in seven assessment domains enabled a trial's risk of bias to be designated as low, unclear or high. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specified domains. A trial was considered to be free of vested interest if it was not funded by a homeopathic pharmacy. The 18 eligible RCTs were disparate in nature, representing four species and 11 different medical conditions. Reliable evidence, free from vested interest, was identified in two trials: homeopathic Coli had a prophylactic effect on porcine diarrhoea (odds ratio 3.89, 95 per cent confidence interval [CI], 1.19 to 12.68, P=0.02); and individualised homeopathic treatment did not have a more beneficial effect on bovine mastitis than placebo intervention (standardised mean difference -0.31, 95 per cent CI, -0.97 to 0.34, P=0.35). Mixed findings from the only two placebo-controlled RCTs that had suitably reliable evidence precluded generalisable conclusions about the efficacy of any particular homeopathic medicine or the impact of individualised homeopathic intervention on any given medical condition in animals. © 2014, British Veterinary Association. All rights reserved. Source

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