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Seattle, WA, United States

Dietsch G.N.,VentiRx Pharmaceuticals
OncoImmunology | Year: 2016

A novel approach to immunotherapy is the activation of toll-like receptor 8 (TLR8). Motolimod, a selective TLR8 agonist can act in concert with approved immunotherapies to sensitize T cells and augment natural killer (NK) cell function. Despite treatment with chemotherapeutic agents and advance disease, cancer patients remain sensitive to motolimod. © Gregory N. Dietsch. Source


Patent
VentiRx Pharmaceuticals | Date: 2011-10-03

The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.


Patent
VentiRx Pharmaceuticals | Date: 2011-04-21

The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In some embodiments, methods are provided for administering to subject to a subject in need thereof a therapeutic antibody in conjunction with an ADCC enhancer molecule.


Patent
University of Pennsylvania and VentiRx Pharmaceuticals | Date: 2011-10-03

The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.


Patent
Array BioPharma and VentiRx Pharmaceuticals | Date: 2014-02-14

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

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