Venkateshwara Institute of Medical science

Gajraula, India

Venkateshwara Institute of Medical science

Gajraula, India
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Gupta S.,Venkateshwara Institute of Medical science | Gulati S.,Venkateshwara Institute of Medical science | Gupta G.,Santosh University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: Noise creates alteration in human health in both physical as well as psychological variations. Effect of noise on components of metabolic syndrome (MetS) has been discussed but not well established. The aim of this study was to investigate the MetS in female workers from textile mill. Methods: A total of 65 female workers were recruited for the study from the high noise (>70 dB) area and low noise (<40 dB) area of a textile mill. Body mass index (BMI), blood pressure (BP), blood sugar (BS), and lipid profile were investigated of the female workers. BP was estimated by auscultatory method. BS was investigated by glucose oxidase-peroxidase (POD) method. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were investigated by cholesterol oxidase (CHOD)-POD method, GPO-PAP method, CHOD-POD/phosphotungustate method, and friedewald formula, respectively. Results: Significant outcomes were obtained in this study. BMI was significantly (<0.01) higher in workers working in high noise area compared to low noise (<40 dB) area. Systolic BP and diastolic BP was also significantly (<0.01) higher in high noise area. Fasting BS level was found to be significantly (<0.01) lower in low noise area. In case of lipid profile significant (<0.01) results were obtained except LDL-C. TC and TG were found to be related with noise since their concentration was higher in high noise area compared to low noise area. However, HDL-C was found to be lower in high noise area compared to low noise area. Conclusion: Continuous exposure to occupational noise might be reason for developing cardiovascular disease depending on the degree of MetS in industrial workers. BP and BS seems to be better predictor of MetS in assessing cardiovascular risk. © 2017 The Authors.


Gupta S.,Santosh University | Malhotra V.,Santosh University | Tripathi Y.,Santosh University | Dev P.,Venkateshwara Institute of Medical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Background: Textile industries play a significant role in the economic growth of the country. Health concern of these textile mill workers is the biggest challenge. Respiratory alterations were found in these workers with long-term exposure to cotton dust. Effect of cotton dust on peak expiratory flow rate (PEFR) is not very well documented in the past. Aim/Objective: The main objective of this study was the assessment of respiratory functions in textile mill workers along with the effect on PEFR in these workers. Methods: A total of 130 male textile mill workers were recruited for this study from the different sections of a textile mill. In which, 80 workers were present from exposed and remaining 50 were from non-exposed area of a textile mill. 30-40 years of age workers with the working history of not more than 5 years, were included in the part of the study. Their body mass index (BMI) and respiratory functions were evaluated. BMI was calculated using weight and height of an individual. Respiratory functions including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were estimated using spirometer, and PEFR was measured by Wright’s peak flow meter. Results: The mean values of FVC, FEV1, and PEFR were found to be significantly (<0.01) lower in the exposed group of the textile mill when compared non-exposed groups. When these values were compared on the basis of BMI, workers with BMI>25 kg/m2 were found with lower mean values of FVC, FEV1, and PEFR when compared with workers with BMI<25kg/m2. Furthermore, there was significant (<0.05) negative correlation between BMI and PEFR in both exposed group and non-exposed group of a textile mill. Conclusion: Workers at the textile mill, with short-term exposure to cotton dust, may also present with respiratory alterations which may increase with long-term exposure. Safety controls, such as ventilation, and routine health check are very much required in textile industries. © 2017 The Authors.


Gupta S.,Santosh University | Malhotra V.,Santosh University | Tripathi Y.,Santosh University | Dev P.,Venkateshwara Institute of Medical science
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2017

Background: Continuous exposure to occupational noise may create physiological derangements of parameters pertaining to stress and anxiety of an individual’s life. Controversial outcomes over the years from different studies made this a topic of debate. Aims and Objective: The aim of this study was to investigate the effect of noise exposure on blood pressure of textile mill workers depending on the intensity of noise. Materials and Methods: A total of 120 male textile mill workers were enrolled for the study. 30 workers from each section including weaving, spinning, packaging and administration section, of the textile mill on the basis of noise level, were selected. They were categorized into groups on the basis of high noise exposure and low noise exposure. The age group criteria for this study were 35-55 years. Blood pressure of this study population was estimated using sphygmomanometer using auscultatory method. Body mass index and heart rate were also noted. Results: Significant results were obtained in this study. 22.5% workers were found to be hypertensive in this study population. The maximum numbers of hypertensive were found in weaving section. 5.8% workers of the total study population were having isolated systolic hypertensive and isolated diastolic hypertensive. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were found be significantly higher in high noise group (<0.05) compared to low noise group. Highest levels of SBP, DBP, MAP, and PP were found in weaving section with noise level between 95 and 100 db. Heart rate was also found to be significantly (<0.05) increased in high noise group. Conclusion: Continuous exposure to occupational noise may lead to adverse changes in blood pressure from mild risk to moderate risk depending on the intensity of noise. It may give lead to cardiovascular abnormalities, e.g., stroke and myocardial infarction. Occupational noise with higher intensity (>90 db) may be associated with hypertension. © 2017 Seema Gupta et al.


Gupta G.,Santosh Medical College | Gupta R.,Venkateshwara Institute of Medical science | Gupta S.,Venkateshwara Institute of Medical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Subclinical hypothyroidism is characterized by dyslipidemia most common in females in elderly. The effect of TSH range is not very well defined in middle aged women. 74 women with 35-45 age group with SCH were enrolled compared on the basis of TSH level. TSH & FT4 were evaluated by enzyme linked immunosorbant assay. Total cholesterol, triglycerides, HDL-cholesterol and LDL- cholesterol were estimated by CHOD-POD method, GPO-PAP method, CHOD-POD/Phosphotungustate method and Friedewald formula respectively. significant results were observed in different parameters among the groups. Total cholesterol, LDL-cholesterol TC/HDL-Cholesterol ratio and LDL/HDL ratio was highly significant (<0.01) among the various groups. HDL-cholesterol and FT4 levels were not significant (>0.05) among the groups. Triglycerides, TC/HDL-cholesterol ratio and LDL/HDL ratio were positively correlated with TSH. Perimenopausal women with subclinical hypothyroidism were characterized by dyslipidemia. SCH groups having TSH (>10μIU/ml) have the higher risk of developing atherosclerosis while in the SCH-1(TSH<10μIU/ml) this risk was not greater. TC/HDL ratio and LDL/HDL ratio were higher in SCH-II and SCH-III suggesting the future development of cardiovascular disease.


Gupta S.,Venkateshwara Institute of Medical science | Gupta R.,Venkateshwara Institute of medical science | Gupta G.,Santosh University | Gupta K.,Birla Institute of Technology and Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Diabetes mellitus is most frequently occurring metabolic disorder. ABO blood group was found to be associated with various disorders. An association between ABO blood group and type 2 diabetes mellitus has been observed in various studies, but conflicting results were obtained.1122 known diabetic patients, both male and female were enrolled for the study. ABO blood group, random blood sugar and body mass index were measured. Slide agglutination method was performed for measuring the ABO blood group. Obesity was measured by body mass index, which was obtained by dividing the weight of an individual by the square of height. Significant results (<0.05) were obtained between male and female population among the various blood groups. There was a significant difference (<0.05) between the obese and non obese persons of type 2 diabetes mellitus. The highest percentage of diabetic patients was observed in B blood group followed by O blood group in both male and female. Among the entire study population approximately 38% patients were having B blood group. Patients having AB blood group were lowest in the entire study population.


Gupta G.,Santosh Medical College | Gupta S.,Venkateshwara Institute of Medical science | Gupta R.,Venkateshwara Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2016

Background: Subclinical hypothyroidism characterised by elevated level of total cholesterol, is controversial. Females are more affected by subclinical hypothyroidism comparing to males. Material & Methods: Total 131 both male & female were enrolled for the study compared with 61 healthy controls. Body mass index, serum concentration of TSH and FT4 and Total cholesterol was measured. Thyroid profile of the participants was estimated by ELISA. Total cholesterol (TC) was measured by CHOD-POD method. Results: SCH patients were characterised by higher body mass index and elevated level of total cholesterol compared to control group (<0.01). Females with SCH were having higher BMI (<0.01) and higher total cholesterol (<0.05) when compared with male of SCH. TSH was positively correlated with TC in male group of SCH (r=0.32, p= <0.05) as well as female group of SCH(r=0.34, p=<0.05). Conclusion: Hypercholesterolemia was associated with subclinical hypothyroidism. Females with SCH were characterised by higher risk of hypercholesterolemia comparing to males. © 2016, Indian Journal of Public Health Research and Development. All rights reserved.

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