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Gupta S.,Venkateshwara Institute of Medical science | Gupta R.,Venkateshwara Institute of Medical science | Gupta G.,Santosh University | Gupta K.,Birla Institute of Technology and Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Diabetes mellitus is most frequently occurring metabolic disorder. ABO blood group was found to be associated with various disorders. An association between ABO blood group and type 2 diabetes mellitus has been observed in various studies, but conflicting results were obtained.1122 known diabetic patients, both male and female were enrolled for the study. ABO blood group, random blood sugar and body mass index were measured. Slide agglutination method was performed for measuring the ABO blood group. Obesity was measured by body mass index, which was obtained by dividing the weight of an individual by the square of height. Significant results (<0.05) were obtained between male and female population among the various blood groups. There was a significant difference (<0.05) between the obese and non obese persons of type 2 diabetes mellitus. The highest percentage of diabetic patients was observed in B blood group followed by O blood group in both male and female. Among the entire study population approximately 38% patients were having B blood group. Patients having AB blood group were lowest in the entire study population. Source


Gupta G.,Santosh Medical College | Gupta R.,Venkateshwara Institute of Medical science | Gupta S.,Venkateshwara Institute of Medical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Subclinical hypothyroidism is characterized by dyslipidemia most common in females in elderly. The effect of TSH range is not very well defined in middle aged women. 74 women with 35-45 age group with SCH were enrolled compared on the basis of TSH level. TSH & FT4 were evaluated by enzyme linked immunosorbant assay. Total cholesterol, triglycerides, HDL-cholesterol and LDL- cholesterol were estimated by CHOD-POD method, GPO-PAP method, CHOD-POD/Phosphotungustate method and Friedewald formula respectively. significant results were observed in different parameters among the groups. Total cholesterol, LDL-cholesterol TC/HDL-Cholesterol ratio and LDL/HDL ratio was highly significant (<0.01) among the various groups. HDL-cholesterol and FT4 levels were not significant (>0.05) among the groups. Triglycerides, TC/HDL-cholesterol ratio and LDL/HDL ratio were positively correlated with TSH. Perimenopausal women with subclinical hypothyroidism were characterized by dyslipidemia. SCH groups having TSH (>10μIU/ml) have the higher risk of developing atherosclerosis while in the SCH-1(TSH<10μIU/ml) this risk was not greater. TC/HDL ratio and LDL/HDL ratio were higher in SCH-II and SCH-III suggesting the future development of cardiovascular disease. Source


Gupta G.,Santosh Medical College | Gupta S.,Venkateshwara Institute of Medical science | Gupta R.,Venkateshwara Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2016

Background: Subclinical hypothyroidism characterised by elevated level of total cholesterol, is controversial. Females are more affected by subclinical hypothyroidism comparing to males. Material & Methods: Total 131 both male & female were enrolled for the study compared with 61 healthy controls. Body mass index, serum concentration of TSH and FT4 and Total cholesterol was measured. Thyroid profile of the participants was estimated by ELISA. Total cholesterol (TC) was measured by CHOD-POD method. Results: SCH patients were characterised by higher body mass index and elevated level of total cholesterol compared to control group (<0.01). Females with SCH were having higher BMI (<0.01) and higher total cholesterol (<0.05) when compared with male of SCH. TSH was positively correlated with TC in male group of SCH (r=0.32, p= <0.05) as well as female group of SCH(r=0.34, p=<0.05). Conclusion: Hypercholesterolemia was associated with subclinical hypothyroidism. Females with SCH were characterised by higher risk of hypercholesterolemia comparing to males. © 2016, Indian Journal of Public Health Research and Development. All rights reserved. Source

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