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Venezia, Italy

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-26-2014 | Award Amount: 4.07M | Year: 2015

Legionnaires disease is a serious form of pneumonia caused by bacterium Legionella pneumophila, with a case-fatality ratio on the order of 10-15%. L. pneumophila proliferates in aquatic habitats, especially in potable water, air conditioning, hot and cold water systems, cooling towers, evaporative condensers, spa/natural pools. Actually, its detection and monitoring rely on time-consuming protocols (in the order of several days) based on in-vitro selective bacteria culture methods, performed by highly specialized personnel in dedicated laboratories. POSEIDON project targets to change the approach in bacteriological environmental monitoring and in infection risk management by developing a fully automatic and reliable system. Handling of the air/water sample will be designed and integrated in preconditioning system and microfluidic device through which whole bacteria cells will be transported from the sampling module to the sensing plasmonic surface. The complete measure protocol will be integrated and performed according to EU legislation guidelines. Specificity will be ensured by immuno-functionalization of gratings surfaces and enhanced system sensitivity will be granted by the optimization of the optical detection system architecture. Sensors based on Grating Coupled Surface Plasmon Resonance (GC-SPR) in azimuthally rotating configuration have recently proved sensitivity enhancement up to almost two orders of magnitude. Furthermore, the symmetry breaking related to grating rotation allows exploiting the incident polarization, more easily controlled with respect to incidence wavelength and angles interrogation. The prototype will be designed to be integrated in water distribution or HVAC systems in order to demonstrate its feasibility in industrially relevant fields and to open new applications and new market opportunities. POSEIDON project aims to address new solutions in this relevant health and safety societal challenge.

Veneto Nanotech S.C.P.A. and Me.Ro S.P.A. | Date: 2011-01-31

A machine for atmospheric plasma treatment of continuous material substrates comprises means for feeding a substrate for moving it along a feed path; at least two electrodes each positioned at one face of the substrate, each electrode facing a respective face of the substrate, a difference in electric potential being applicable across the electrodes for generating an electric discharge; the feed means comprising at least one first roller and one second roller, the first roller and the second roller coinciding with respective electrodes and each acting on a respective face of the substrate.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2011.1.2-2 | Award Amount: 10.76M | Year: 2012

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication). The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-02-2014 | Award Amount: 3.95M | Year: 2015

The function of a lower limb prosthetic is highly dependent upon the characteristics and anatomical profile of the residual limb. This is unique to each individual and changes depending on the activities being engaged in by the amputee. A poorly fitting prosthetic socket can cause significant trauma so it is important to consider how to optimise the fit to maximise the amputees comfort whilst wearing the limb prosthesis. Current practice in designing a prosthetic socket is time-consuming, and is highly dependent on the experience of the prosthetist. The SocketMaster project aims to integrate micro electronic, mechanical (pressure and acceleration), fluidic biomechanical and moisture sensors into a Master Socket which can help prosthetists to achieve fast customised design and manufacturing of prosthetic sockets for lower limb (trans-femoral and trans-tibial) amputees. Firstly, existing micro sensors such as piezoelectric, MEMS based pressure sensors will be adapted or developed so that pressure distributions within the interface between the residual limb and the socket can be measured. Secondly, a Master Socket will be built by assembling the sensor system in a rigid hosting socket in such a way that the sensors positions can be adjusted to achieve a comfortable configuration for the patient. The pressure distributions at typical activities of a patient will be used to optimise the socket design to maximise the patients comfort. The digital 3D data of the optimised socket design can be fed into a rapid prototyping machine for fast fabrication. Thirdly, clinical trials will be carried out to validate the Master Socket. It is envisaged that SocketMaster will enable same day socket fabrication with optimised quality, and the fit and function of the prosthetic socket will be less dependent on the skills of the prosthetist.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.3-3 | Award Amount: 49.52M | Year: 2013

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answers needed by regulators and legislators on EHS by linking them to a scientific evaluation of data and test methods. Based on questions and requirements supplied by regulators and legislators, NANoREG will: (i) provide answers and solutions from existing data, complemented with new knowledge, (ii) Provide a tool box of relevant instruments for risk assessment, characterisation, toxicity testing and exposure measurements of MNMs, (iii) develop, for the long term, new testing strategies adapted to innovation requirements, (iv) Establish a close collaboration among authorities, industry and science leading to efficient and practically applicable risk management approaches for MNMs and products containing MNMs. The interdisciplinary approach involving the three main stakeholders (Regulation, Industry and Science) will significantly contribute to reducing the risks from MNMs in industrial and consumer products. NANoREG starts by analysing existing knowledge (from WPMN-, FP- and other projects). This is combined with a synthesis of the needs of the authorities and new knowledge covering the identified gaps, used to fill the validated NANoREG tool box and data base, conform with ECHAs IUCLID DB structure. To answer regulatory questions and needs NANoREG will set up the liaisons with the regulation and legislation authorities in the NANoREG partner countries, establish and intensify the liaisons with selected industries and new enterprises, and develop liaisons to global standardisation and regulation institutions in countries like USA, Canada, Australia, Japan, and Russia.

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