Veneto Institute of Oncology IOV

Padova, Italy

Veneto Institute of Oncology IOV

Padova, Italy
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Thibault F.,University Pierre and Marie Curie | Dromain C.,Institute Of Cancerologie Gustave Roussy | Breucq C.,Universitair Ziekenhuis | Balleyguier C.S.,Institute Of Cancerologie Gustave Roussy | And 5 more authors.
European Radiology | Year: 2013

Objectives: To compare the diagnostic performance of single-view breast tomosynthesis (BT) with that of dual-view mammography (MX); to assess the benefit of adding the craniocaudal (CC) mammographic view to BT, and of adding BT to MX plus breast ultrasound, considered to be the reference work-up. Methods: One hundred and fifty-five consenting patients with unresolved mammographic and/or ultrasound findings or breast symptoms underwent conventional work-up plus mediolateral oblique-view BT of the affected breast. The final study set in 130 patients resulted in 55 malignant and 76 benign and normal cases. Seven breast radiologists rated the cases through five sequential techniques using a BIRADS-based scale: MX, MX + ultrasound, MX + ultrasound + BT, BT, BT + MX(CC). Multireader, multicase receiver operating characteristic (ROC) analysis was performed and performance of the techniques was assessed from the areas under ROC curves. The performance of BT and of BT + MX(CC) was tested versus MX; the performance of MX + ultrasound + BT tested versus MX + ultrasound. Results: Tomosynthesis was found to be non-inferior to mammography. BT + MX(CC) did not appear to be superior to MX, and MX + ultrasound + BT not superior to MX + ultrasound. Conclusions: Overall, none of the five techniques tested outperformed the others. Further clinical studies are needed to clarify the role of BT as a substitute for traditional work-up in the diagnostic environment. Key Points: • Digital breast tomosynthesis is a new adjunct to mammography and breast ultrasound. • We compared the diagnostic performance of these investigations in an experimental observer study. • Single-view breast tomosynthesis was confirmed as non-inferior to dual-view mammography. • None of the investigations (or combinations) tested outperformed the others. • Further prospective studies are needed to clarify precise role of tomosynthesis for diagnostic application. © 2013 European Society of Radiology.


Gennaro G.,Veneto Institute of Oncology IOV | Ballaminut A.,CyberQual srl | Contento G.,CyberQual srl
European Radiology | Year: 2017

Objectives: This study aims to illustrate a multiparametric automatic method for monitoring long-term reproducibility of digital mammography systems, and its application on a large scale. Methods: Twenty-five digital mammography systems employed within a regional screening programme were controlled weekly using the same type of phantom, whose images were analysed by an automatic software tool. To assess system reproducibility levels, 15 image quality indices (IQIs) were extracted and compared with the corresponding indices previously determined by a baseline procedure. The coefficients of variation (COVs) of the IQIs were used to assess the overall variability. Results: A total of 2553 phantom images were collected from the 25 digital mammography systems from March 2013 to December 2014. Most of the systems showed excellent image quality reproducibility over the surveillance interval, with mean variability below 5%. Variability of each IQI was 5%, with the exception of one index associated with the smallest phantom objects (0.25 mm), which was below 10%. Conclusions: The method applied for reproducibility tests—multi-detail phantoms, cloud automatic software tool to measure multiple image quality indices and statistical process control—was proven to be effective and applicable on a large scale and to any type of digital mammography system. Key Points: • Reproducibility of mammography image quality should be monitored by appropriate quality controls.• Use of automatic software tools allows image quality evaluation by multiple indices.• System reproducibility can be assessed comparing current index value with baseline data.• Overall system reproducibility of modern digital mammography systems is excellent.• The method proposed and applied is cost-effective and easily scalable. © 2017 European Society of Radiology


PubMed | University of Padua, University of Verona, Instituto Oncologico Veneto IOV, Instituto Oncologico Veneto IRCCS and 6 more.
Type: | Journal: Clinical cancer research : an official journal of the American Association for Cancer Research | Year: 2017

LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features of the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated the role of LKB1 as potential predictive marker of sensitivity to bevacizumab in advanced non-small cell lung cancer (aNSCLC).We retrospectively analyzed LKB1 expression by immunohistochemistry in 98 samples out of 125 aNSCLC patients, including 59 patients treated with chemotherapy (CT) and 39 treated with CT plus bevacizumab. IHC intensity was re-coded in two classes (negative/weak versus moderate/intense) and correlated with outcome according to treatment arm. Patient-derived tumor xenografts (PDXs) were used to investigate mechanisms involved in preclinical models.In the whole study population (125), median OS and PFS were 11.7 (95%IC: 9.1-15.3) and 6.7 (95%IC: 5.7-7.2) months, respectively. Differential impact of the marker on outcome of the 98 patients was highlighted according to treatment. Patients with negative/weak LKB1 status had not a statistically significant benefit from bevacizumab added to CT (HR for patients treated with bevacizumab: 0.89, 95% CI: 0.51-1.56, p=0.6803), whereas patients expressing moderate/intense LKB1 and receiving bevacizumab had significant lower risk of death compared to those not receiving bevacizumab (HR: 0.26, 95% CI: 0.10-0.64); p=0.0035). Loss of LKB1 was associated with reduced AMPK activation in PDXs and increased tumor necrosis following bevacizumab administration, highlighting impaired control of the metabolic stress caused by this antiangiogenic drug.Our data hint at a possible predictive impact of LKB1 expression in aNSCLC patients treated with CT plus Bevacizumab.


Battaglia G.,Veneto Institute of Oncology IOV | Antonello A.,Veneto Institute of Oncology IOV | Realdon S.,Veneto Institute of Oncology IOV | Cesarotto M.,Veneto Institute of Oncology IOV | And 3 more authors.
Digestive Endoscopy | Year: 2015

Background and Aim Flexible endoscopic septum division is becoming a prominent treatment option for Zenker's diverticulum (ZD). Over the years, various techniques have been developed and many cutting tools have been tested with varying results. We report our experience with a recently designed, monopolar, rotating, scissor-shaped device (SB Knife). Methods Data on 31 consecutive patients that underwent flexible endoscopic treatment for ZD with the use of the SB Knife were retrieved. Dysphagia, regurgitation, and respiratory symptom severity before the procedure were graded. Procedure duration, rate of complications, symptom changes after the procedure and rate of relapsing patients during follow up were recorded. Results The procedure was carried out successfully in all patients. Median procedure time was 14 min. One case of late-onset bleeding developed 1 week after the procedure, and was managed endoscopically. A significant symptom improvement was achieved (dysphagia: median score <3, median score >0, P < 0.001; regurgitation: median score <2, median score >0, P < 0.001; respiratory symptoms: median score <2, median score >0, P = 0.009). Two patients had mild relapsing symptoms, respectively, after 4 and 9 months from the procedure but refused further treatment. Conclusions Endoscopic treatment of ZD using this new device is safe and efficient at short term follow up. No perforations were observed and there was a substantial reduction of symptoms after the treatment. Larger studies are needed to fully assess advantages of this new device for endoscopic treatment of ZD. © 2015 The Authors. Digestive Endoscopy © 2015 Japan Gastroenterological Endoscopy Society.


Guttilla A.,University of Padua | Bortolami A.,Veneto Institute of Oncology IOV | Evangelista L.,Oncology and Radiotherapy Institute
Quarterly Journal of Nuclear Medicine and Molecular Imaging | Year: 2015

In western countries, prostate cancer (PCa) is the most common non-dermatological malignant disease in men. Bone metastases more often develop in patients with advanced PCa; the associated complications present a substantial disease and economic burden. Although the introduction of new therapeutic strategies have provided some advantages in terms of overall survival and quality of life in patients with metastatic PCa, the skeletal related events and side effects due to the therapies are associated with an important impact on the healthcare costs. In particular, the number of hospital admission, clinical consultation and the introduction of new expensive diagnostic modalities have changed the management of metastatic patients. However, the National and International guidelines suggest to follow patients with metastatic PCa by using clinical assessment, biochemical evaluation and, when necessary, diagnostic imaging. The aims of the present review were: 1) to summarize the information regarding the clinical and economic burden of metastasis; 2) to evaluate the quality of life; and 3) to suggest a proper follow-up in advanced PCa patients.


Rubaltelli L.,University of Padua | Beltrame V.,University of Padua | Scagliori E.,Venetian Oncology Institute IOV | Bezzon E.,Venetian Oncology Institute IOV | And 3 more authors.
Ultraschall in der Medizin | Year: 2014

Purpose: Malignant melanoma represents a significant and growing public health burden worldwide. Ultrasonography is the most useful diagnostic modality for regional lymph nodal staging. Because any focal areas of cortical lobulation or thickening-swelling should also be considered as a sign of metastases, we are going to report the usefulness of contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of benign or malignant lymph nodes in patients with malignant melanoma based on blood stream patterns and investigate the diagnostic capability. Patients and Methods: After the excision of cutaneous melanoma with positive excision margins but with negative sentinel lymph node, 540 patients underwent US of superficial lymph nodes. The inclusion criteria for CEUS consisted of both major signs (absence of the echogenic hilus, round shape, and peripheral capsular vascularity) and minor ones (the presence of focal cortical thickening). The diagnostic capability was evaluated by comparing the cytological findings with the enhancement pattern on CEUS.€Š Results: US in combination with CEUS correctly classified 534/540 patients. CEUS applied to lymph nodes with focal cortical thickening on grayscale US confirmed great sensitivity (0.98) and specificity (0.99) but above all, it showed a markedly improved accuracy of 0.99. The likelihood ratios confirmed the good performance of the methods used. Conclusion: CEUS increases the diagnostic accuracy of US in the differential diagnosis of benign and malignant LNs but it also allows us, when possible, to avoid unnecessary invasive operations such as LN FNAC. Moreover, CEUS may guide FNAC in the case of focal cortical thickening on the basis of hypoperfusion, with a reduction in the number of false negatives and much earlier detection of nodal metastatic foci. © Georg Thieme Verlag KG Stuttgart. New York.


Sommariva A.,Veneto Institute of Oncology IOV | Zagonel V.,Veneto Institute of Oncology IOV | Rossi C.R.,Veneto Institute of Oncology IOV | Rossi C.R.,University of Padua
Annals of Surgical Oncology | Year: 2012

Background. Cytoreductive surgery (CS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) was developed as locoregional treatment for primary or secondary peritoneal tumors. The role of laparoscopy over several stages of diagnosis and the treatment of the patients affected by peritoneal carcinomatosis and selected for CS + HIPEC shows some peculiarities, and their potential application in this field is not fully known. Our aim was to review and summarize the applications, the results, and the future directions of laparoscopy in the management of the patients affected by carcinomatosis and scheduled for CS + HIPEC. Methods. Appropriate keywords were adopted to identify the relevant studies on this topic in PubMed/Medline electronic databases. Results. The role of laparoscopy in diagnosis and staging of patients selected for CS + HIPEC seems to have a great but probably underestimated potential. Laparoscopic CS + HIPEC is technically feasible with an acceptable morbidity profile, especially in patients with low tumor load. In selected patients with malignant ascites, laparoscopic HIPEC achieves a good palliative effect, with a low morbidity profile. Conclusions. Laparoscopy plays a partially explored role in diagnosis and staging of patients selected for CS + HIPEC. The use of laparoscopic HIPEC with an adjuvant, curative, or palliative intent seems feasible, but further studies are required in order to explore and validate all potential indications. For all these reasons, it would be advisable to provide every HIPEC center with specific laparoscopic skills. © Society of Surgical Oncology 2012.


Barzon L.,University of Padua | Pacenti M.,University of Padua | Sinigaglia A.,Veneto Institute of Oncology IOV | Berto A.,University of Padua | And 2 more authors.
Expert Review of Anti-Infective Therapy | Year: 2015

West Nile virus (WNV) is an emerging flavivirus responsible for an increasing number of outbreaks of neuroinvasive disease in North America, Europe, and neighboring countries. Almost all WNV infections in humans are transmitted through the bite of infected mosquitoes. Transmission during pregnancy and through breastfeeding has been reported, but the risk seems to be very low. West Nile disease in children is less common (1-5% of all WNV cases) and associated with milder symptoms and better outcome than in elderly individuals, even though severe neuroinvasive disease and death have been reported also among children. However, the incidence of WNV infection and disease in children is probably underestimated and the disease spectrum is not fully understood because of lack of reporting and underdiagnosis in children. Infection is diagnosed by detection of WNV-specific antibodies in serum and WNV RNA in plasma and urine. Since no effective WNV-specific drugs are available, therapy is mainly supportive. © 2015 Taylor and Francis.


PubMed | CyberQual srl and Veneto Institute of Oncology IOV
Type: | Journal: European radiology | Year: 2017

This study aims to illustrate a multiparametric automatic method for monitoring long-term reproducibility of digital mammography systems, and its application on a large scale.Twenty-five digital mammography systems employed within a regional screening programme were controlled weekly using the same type of phantom, whose images were analysed by an automatic software tool. To assess system reproducibility levels, 15 image quality indices (IQIs) were extracted and compared with the corresponding indices previously determined by a baseline procedure. The coefficients of variation (COVs) of the IQIs were used to assess the overall variability.A total of 2553 phantom images were collected from the 25 digital mammography systems from March 2013 to December 2014. Most of the systems showed excellent image quality reproducibility over the surveillance interval, with mean variability below 5%. Variability of each IQI was 5%, with the exception of one index associated with the smallest phantom objects (0.25mm), which was below 10%.The method applied for reproducibility tests-multi-detail phantoms, cloud automatic software tool to measure multiple image quality indices and statistical process control-was proven to be effective and applicable on a large scale and to any type of digital mammography system. Reproducibility of mammography image quality should be monitored by appropriate quality controls. Use of automatic software tools allows image quality evaluation by multiple indices. System reproducibility can be assessed comparing current index value with baseline data. Overall system reproducibility of modern digital mammography systems is excellent. The method proposed and applied is cost-effective and easily scalable.


Lombardi G.,Veneto Institute of Oncology IOV | Di Stefano A.L.,Groupe Hospitalier Pitie Salpetriere | Di Stefano A.L.,University of Pavia | Farina P.,Veneto Institute of Oncology IOV | And 3 more authors.
Cancer Treatment Reviews | Year: 2014

The frequency of metastatic brain tumors has increased over recent years; the primary tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma. While radiation therapy and surgery remain the mainstay treatment in selected patients, new molecular drugs have been developed for brain metastases. Studies so far report interesting results.This review focuses on systemic cytotoxic drugs and, in particular, on new targeted therapies and their clinically relevant activities in brain metastases from solid tumors in adults. © 2014 Elsevier Ltd.

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