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Gennaro G.,Venetian Oncological Institute IOV | Toledano A.,Statistics Collaborative Inc. | Di Maggio C.,University of Padua | Baldan E.,Venetian Oncological Institute IOV | And 9 more authors.
European Radiology | Year: 2010

Objective: To compare the clinical performance of digital breast tomosynthesis (DBT) with that of fullfield digital mammography (FFDM) in a diagnostic population. Methods: The study enrolled 200 consenting women who had at least one breast lesion discovered by mammography and/or ultrasound classified as doubtful or suspicious or probably malignant. They underwent tomosynthesis in one view [mediolateral oblique (MLO)] of both breasts at a dose comparable to that of standard screen-film mammography in two views [craniocaudal (CC) and MLO]. Images were rated by six breast radiologists using the BIRADS score. Ratings were compared with the truth established according to the standard of care and a multiple-reader multiplecase (MRMC) receiver-operating characteristic (ROC) analysis was performed. Clinical performance of DBTcompared with that of FFDMwas evaluated in terms of the difference between areas under ROC curves (AUCs) for BIRADS scores. Results: Overall clinical performance with DBT and FFDM for malignant versus all other cases was not significantly different (AUCs 0.851 vs 0.836, p=0.645). The lower limit of the 95% CI or the difference between DBT and FFDM AUCs was -4.9%. Conclusion: Clinical performance of tomosynthesis in one view at the same total dose as standard screen-film mammography is not inferior to digital mammography in two views. © European Society of Radiology 2009. Source

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