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Hariram S.B.,Veltech Hightech Dr Rangarajan Dr Sakuntala Engineering College | Jayaraman P.,Veltech Hightech Dr Rangarajan Dr Sakuntala Engineering College | Palaniraj A.,Veltech Hightech Dr Rangarajan Dr Sakuntala Engineering College | Jawahar N.,Veltech Hightech Dr Rangarajan Dr Sakuntala Engineering College | Vidhya K.,Veltech Hightech Dr Rangarajan Dr Sakuntala Engineering College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Presently mixed formulations [pyretheroids with organophosphates] are in agricultural practice to reduce the organophosphate toxicity and to have better pesticidal efficay due to the synergetic effect of its constituents. Hence a 28 days sub acute studies were designed by administering 1/10,1/20 and 1/40 th of LD50 dosage daily through oral gavage for 28 days. The Blood samples were collected from both experimental and control Rats to asses the biochemical markers like Creatinine,glucose blood urea nitrigen, Alkaline phosphatase, ALT and AST.The results are quite interesting to note that both male and female experimental animals showed a significant increase in glucose, creatinine and ALP was observed in higher dosed groups [III and IV] when compared to untreated control whereas other biochemical markers did not showed any significane.From the results it is evident that the organs like pancreas[glucose],kidney[creatinine] and bone [ALP] showed marginal change in their biochemical markers only in the higher doses with out showing any significant change in the lower doses due to the reduced toxicity [which is due to the less composition of organophosphate and its best pesticidal property is due to synergetic effect of its constituents in the combination pesticide].such studies on combination pesticide will help us to identify a best combination pesticide showing remarkable pesticidal property and lower toxicity in human and domestic animals. © 2010 RJPBCS. Source

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