Vel Technology University Avadi

Chennai, India

Vel Technology University Avadi

Chennai, India
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Chellaram C.,Vel Technology Multitech | Chellaram C.,Vel Technology University Avadi
International Journal of PharmTech Research | Year: 2015

Bacteria are common populace of surfaces and the internal tissues of most plants. These bacteria contribute to the health, growth and development of plants. In this study, 45 strains were isolated from Phyllanthus niruri plant leaves. Phyllanthus niruri is a medicinal plant used popularly to cure jaundice. Endophytic bacteria isolated were tested against human pathogens and the active strain was identified. Ethyl acetate extract of the strain 13 shows activity against Candida albicans, Klebsiella pneumoniae and Escherichia coli. High Performance Liquid Chromatography (HPLC) and Matrix Assisted Laser Desorption Ionization – Time of Flight (MALDI-TOF) analysis were done. The data shows the presence of active compounds. Thus, the endophytic bacteria may yield a vast array of new compounds with novel activities that will provide new drugs in the fight against a number of pathogens currently resistant to conventional antibiotic therapies. © 2015, Sphinx Knowledge House. All Right reserved.


Gladis Raja Malar C.,Sathyabama University | Chellaram C.,Vel Technology Multitech | Chellaram C.,Vel Technology University Avadi
Der Pharmacia Lettre | Year: 2015

The study was conducted to determine the antioxidant activity, total phenol and flavonoid content of the stem of Salacia oblonga, collected from five geographically distant regions of Western Ghat, Karnataka were examined using extracts of aqueous, ethanol, methanol, chloroform and petroleum ether. The five different solvent extracts of S. oblonga stem were evaluated for antioxidant activities by DPPH (1,1 - diphenyl-2-picryl-hydrazyl) radical scavenging activity using Butylated Hydroxy Toluene (BHT) as standard. Among five accessions with different solvents used, maximum antioxidant activity was found in aqueous stem extract (84.3 %) from Hubli(2) followed by others. Total phenol and flavonoid contents were quantitatively estimated. The aqueous stem extract of Salacia oblonga (Hubli(2) - Karnataka) was found maximum in total phenol and flavonoid contents were 34.63 mg GAE /g and 18.72 mg QE /g respectively. The aqueous stem extracts of S. oblonga had superior level of antioxidant activity. The powerful free radical scavenging effect is attributed to the greater amount of phenol and flavonoid compounds in the aqueous stem extract.


Vaidyanathan S.,Vel Technology University Avadi
International Journal of PharmTech Research | Year: 2015

Recent research has shown that many physical, chemical and biological nonlinear dynamical systems can exhibit an apparently unpredictable and chaotic manner. This realization has broad implications and applications in many fields of science such asphysics, chemistry, biology, ecology, secure communications, cryptosystems, etc. This paper investigates research in the dynamic and chaotic analysis of enzymes-substrate reactions system with ferroelectric behaviour in brain waves which was studied by Enjieu Kadji, Chabi Orou, Yamapi and Woafo (2007). The enzymes-substrates system is a 2-D non-autonomous system with a cosinusoidal forcing term. This paper displays the phase portraits of the 2-D enzymessubstrates system when the system undergoes chaotic behaviour. Next, this paper derives adaptive backstepping control for globally stabilizing the trajectories of the enzyme-substrates system with unknown parameters. All the main results are proved using Lyapunov stability theory. Also, numerical simulations have been plotted using MATLAB to illustrate the main results for the enzyme-substrates system. © 2015, Sphinx Knowledge House. All Right reserved.


Gomathi G.,Anna University | Srinivasan T.,Vel Technology University Avadi | Velmurugan D.,University of Madras | Gopalakrishnan R.,Anna University
RSC Advances | Year: 2015

The present paper describes the physicochemical properties and biological activities of an organic single crystal, methyl 3-[(E)-(2-hydroxy-1-naphthyl)methylidene]carbazate which was grown by the slow evaporation solution growth technique. A powder X-ray diffraction study of the compound was carried out and the (hkl) values were found to be comparable with the reported values. The vibrational properties of the compound were analysed on the basis of FT-IR and FT-RAMAN spectra. The proton NMR spectrum was consistent with the chemical structure of the compound. From UV-VIS-DRS analysis and fluorescence studies, the absorption range and the bluish-green emission property of the title compound were found. The melting point of the compound was found to be at 205 °C from the TG-DTA-DSC analysis. The antimicrobial activities of the title compound were screened using the resazurin reduction assay against human pathogenic bacteria such as Shigella dysenteriae, Vibrio cholerae, Streptococcus faecalis, and Bacillus cereus and fungi such as Candida krusei, Candida albicans, and Candida glabrata. Molecular docking studies demonstrated that the title compound could bind well with the active site of human estrogen receptor and act as a potential inhibitor of ERα and ERβ. This journal is © The Royal Society of Chemistry.


Nagarajan S.,Vel Technology University Avadi | Shaikh T.M.,Vel Technology University Avadi | Kandasamy E.,Vel Technology University Avadi
New Journal of Chemistry | Year: 2015

An efficient protocol has been developed for the synthesis of 2,3-dihydroquinazolinone compounds from anthranilamide and aldehydes or ketones via ionic liquid catalyzed cyclization reaction. The reaction features high efficiency, shorter reaction duration, mild reaction conditions and inexpensive reagents. The catalyst was recovered and reused. The recyclability of ionic liquid resulted in excellent yields of products without loss of any catalytic activity. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

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