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Priya G.,Sathyabama University | Chellaram C.,Vel Technology Multitech Engineering College
International Journal of Pharma and Bio Sciences | Year: 2014

The ethanolic leaf extracts of Solanum trilobatum plant were used for antibacterial study by disc diffusion method. Different concentrations (10mg/ml, 20mg/ml, 30mg/ml) of the concentrated ethanolic leaf extract were tested for its antibacterial activity against bacterial strains such Bacillusubstilis, Staphylococcus aureus, Bacillus cereus, E. Cali & Pseudomonas aeruginosa. The bacterial cultures were grown in Muller hinton agar and Muller hinton broth. The zone of inhibition was comparatively more in the concentration of 30mg/ml. Phytochemical screening of the ethanolic leaf extract of the plant revealed the presence of tannins, saponins, flavonoids, carbohydrates and alkaloids. Thin Layer Chromatography (TLC) value of the leaf extract showed the highest Retention Factor (RF) value. The plant extracts showed better inhibitory activity against the tested organisms. Source

Thangeeswari T.,Vel Technology Multitech Engineering College | Thangeeswari T.,Anna University | Priya M.,Saveetha Engineering College | Velmurugan J.,Anna University | Padmanathan N.,Anna University
Bulletin of Materials Science | Year: 2015

Well-crystalline structured ZnO nanoparticles with cobalt (Co) and ytterbium (Yb) multiple ions doping were successfully synthesized by the chemical precipitation technique. The structures, optical and magnetic properties of the samples were analysed with X-ray diffraction (XRD), UV-visible spectroscopy and magnetic measurements, respectively. In the XRD pattern of the pure ZnO and Yb co-doped samples, the formation of highly crystalline phase of pure ZnO was observed even at high Yb concentration. UV-vis spectra show a strong UV absorbance for all the samples with different absorbance maxima. Magnetic characterizations have shown that the sample with 1% Yb co-doped ZnO: Co nanoparticles exhibited a clear ferromagnetic (FM) behaviour at room temperature. The X-ray photoelectron spectral peaks for Yb 4f ions reveal Yb occupation of both Yb3+ as well as Yb2+ states. Hence, it can be confirmed that a clear FM behaviour at room temperature was exhibited by an imbalanced valence state of Yb that strongly interacted with the Co2+. When compared to the Co-doped ZnO, Yb co-doped ZnO exhibits a clear ferromagnetism at room temperature with high coercivity due to the contribution of both 3d and 4f exchange interaction with the host matrix. © 2015 Indian Academy of Sciences. Source

Priya G.,Sathyabama University | Chellaram C.,Vel Technology Multitech Engineering College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: To analyze the antioxidant and antiproliferative potential of Solanum trilobatum was evaluated. Methods: Free radical scavenging potential of the plant was studied by various in vitro assays such as DPPH, ßCarotene and Frap assay. The antiproliferative activity of Solanum trilobatum was analysed by MTT assay. Result: The ethanol extract is more powerful in scavenging free radicals. The preliminary phytochemical screening of Solanum trilobatum revealed the presence of phenolics, carbohydrates alkaloids, flavonoids and tannins in high amount. The antiproliferative potential of the ethanol extract was studied on Hep2 cell lines by MTT assay. The extract had an IC50 value of100μg/mL which showed cell viability of 22.67%. From the result, it is clear that ethanol extract of Solanum trilobatum has cytotoxic effect on Hep2 cell lines. Conclusion: Thus, the study revealed that Solanum trilobatum could be considered as a significant source of antioxidant and antiproliferative agents. Source

Govindarajan P.,Sathyabama University | Chinnachamy C.,Vel Technology Multitech Engineering College
Pakistan Journal of Pharmaceutical Sciences | Year: 2014

This study focuses on the phytochemical properties and the anti-hepatocarcinogenic effects of the leaf and in vitro-derived callus and shoot extracts of Solanum trilobatum. In the leaf, callus and shoot, the presence of sugar, proteins, alkaloids, flavonoids, saponins, tananins, cardiacglycoside, terpenoid and lipids was established by preliminary phytochemical screening. Surface-sterilized explants (0.5-1.0 cm) were placed on the MS basal medium supplemented with different concentrations of 2,4-dichlorophenoxyacetic acid (0.45, 2.26, 4.52, 11.31 and 12.56μM), naphthylacetic acid (NAA; 0.54, 1.34, 2.69, 5.37, 13.43 and 26.85μM) and 6-benzylaminopurine (BA; 0.44, 1.11, 2.22, 4.44, 8.88 and 13.32μM) for callus induction. Explants from node and callus culture were inoculated on the MS basal medium supplemented with varying concentrations of BA (0.44-22.20 μM) and NAA (0.54-10.74μM) for shoot multiplication. Rats were divided into five groups and administered with diethyl nitrosamine (DEN) and DEN (200mg/kg bwt) intraperitoneally along with methanol leaf and in vitro-derived callus and shoot extracts (250mg/kg bwt) orally for 3 months. A significant deviation (P<0.05) in marker enzymes such as alanine transaminase, aspartate transaminase, lactate dehydrogenase and total bilirubin was found in rats administered with DEN. The liver tissue was used for the analysis of glutathione reductase, lipid peroxidation, glutathione peroxidase, glutathione S-transferase, superoxide dismutase and catalase. DEN administration caused a significant elevation in serum enzymes and total bilirubin. Moreover, antioxidant enzymes were drastically inhibited with significant reduction in glutathione and increased lipid per oxidation. Increased glutathione level and reduced lipid peroxidation were also evident in S. trilobatum-treated rats. However, crude S. trilobatum and in vitro-derived callus and shoot extracts offered better protection against free radical toxicity induced by DEN. Source

Punitha S.,The New School | Thompson S.,Vel Technology Multitech Engineering College | Siva Rama Lingam N.,RMK Engineering College
Electronics Information and Planning | Year: 2010

Programming models that support code migration have gained prominence, mainly due to a widespread shift from stand alone to distributed applications. Although appealing in terms of system design and extensibility, mobile programs are a security risk and require strong access control. Further, the mobile code environment is fluid - the programs and resources located on a host may change rapidly, necessitating an extensible security model. In this paper, we present the design and implementation of a security infrastructure. This infrastructure is built around an event/response mechanism, in which a response is executed when a security-related event occurs. We support a finegrained, conditional access control language, and enforce policies by instrumenting the bytecode of protected classes. This method enhances efficiency and promotes separation of concerns between security policy and program specification. This infrastructure also allows security policies to change at runtime, adapting to varying system state, intrusion, and other events. Source

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