Veerayatan Institute of Pharmacy

Kutch, India

Veerayatan Institute of Pharmacy

Kutch, India

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Vidyasagar G.,Veerayatan Institute of Pharmacy | Sambasiva Rao K.R.S.,Acharya Nagarjuna University
Journal of Applied Pharmaceutical Science | Year: 2011

A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination levocetirizine has been developed. The chromatographic system consisted of a Water 2695 binary gradient pump, Water 2487 dual wavelength absorbance detector, and Empower 2 software. Separation was achieved on the XTerra symmetry C18 column at room temperature. The sample was introduced through an injector valve with a 20 μL sample loop. The results obtained showed a good agreement with the declared content. Recovery values of levocetirizine in tablets were from 99.57-100.48 %. The proposed method is rapid, accurate and selective; it may be used for the quantitative analysis of levocetirizine from raw materials, in bulk drugs and other dosage formulations.


Karunakar B.,National PG College Nandyala | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The present paper deals with hydro distillation of Achyranthus aspera seeds and GC-MS analysis. The total composition of the oil was 76.7%. The Achyranthus aspera seed volatile oil was tested against pathogenic bacteria and Fungi.


Vidyasagar G.,Veerayatan Institute of Pharmacy | Sambasiva Rao K.R.S.,Acharya Nagarjuna University
Der Pharma Chemica | Year: 2011

Reversed phase high performance liquid chromatographic method was developed and validated for the estimation of Olmesartan medoxomil in bulk and formulation. Selected mobile phase was a combination of phosphate buffer with pH adjusted at 2.8 and acetonitrile (35:65% v/v) and wavelength selected was 250 nm. Retention time of Olmesartan medoxomil was 2.591 min. Linearity of the method was found to be 50-150 μg/ml, with the regression coefficient of 0.9993. Quantification was done by calculating area of the peak and the detection limit and quantitation limit ware 0.02μg/mL and 0.09μg/mL, respectively. There was no significant difference in the intraday and inter day analysis of Olmesartan medoxomil determined for three different concentrations using this method. Present method can be applied for the determination of Olmesartan medoxomil in quality control of formulation without interference of the excipients.


Kumar G.G.,Suresh Gyan Vihar University | Gali V.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

Medicinal plants have been used in all cultures throughout history. Extensive scientific documentation now exists concerning their use for health conditions including many disorders. Medicinal plants are of great importance to the health of individuals and communities. Hence the Author proposes to screen the some above mentioned drugs. The present paper deals with the screening of various phytochemical present in various extract viz., Methanol (80%), Distilled water with chloroform (2.5%) of Abutilon muticum (Del.ex DC.) and Celosia argentea Linn.


Vidya Sagar D.,Veerayatan Institute of Pharmacy | Shaik A.B.,Andhra University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Pyrimidine derivatives are a group of heterocyclic compounds which are associated with a wide variety of biological activities. Broad spectrum of biological activities of pyrimidine derivatives elated to synthesize a series of some new different pyrimidine derivatives by condensation of different chalcones with guanidine hydrochloride in the presence of potassium hydroxide as catalyst. The synthesized pyrimidine derivatives were purified by either recrystallization or column chromatographic techniques. The characterization of the purified pyrimidine derivatives was done by IR, 1H NMR spectral data and elemental analysis. These compounds were further screened for anti-inflammatory and cytotoxic activities using standard protocols. When these pyrimidine derivatives were evaluated for anti-inflammatory and cytotoxic activities some of them found to possess significant biological activity when compared to standard drugs.


Mehta P.S.,Veerayatan Institute of Pharmacy | Patel V.B.,Babaria Institute of Pharmacy
Asian Journal of Chemistry | Year: 2013

A simple, precise and accurate reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of guaiphenesin, dextromethorphan hydrobromide and bromohexine hydrochloride in their soft gel formulations. The chromatographic conditions were standardized using Phenomenex Luna C18 (250 mm × 4.6 mm i.d., 5 μm particle size) with UV detection at 258 nm and mobile phase consisting of methanol: 0.05 M phosphate buffer pH 3.0 (60 : 40 v/v). Mobile phase was delivered at the flow rate of 1.3 mL/min and separation was completed within 8 min. The retention times of guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride were 3.1 min, 4.1 min and 6.8 min respectively. Calibration curves were linear with correlation coefficient 0.998. 0.999 and 0.999 over a concentration range of 50-250, 5-25 and 1-6 μg/mL for guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride respectively. Recoveries were between 97.04-100.15, 101.92-104.67 and 102.01-102.55 respectively. The proposed method was validated and successfully applied to the estimation of three drugs in combined soft gel formulation.


Padmalatha H.,University of Rajasthan | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

Quantitative estimation of Candesartan was carried out by UV spectrophotometry using methanol as solvent. The task was performed at 212nm (λmax). Beer's law range was found to be 2-12 μ g/ml. This method was validated as per ICH guidelines by using several parameters like accuracy, precision, linearity, LOD &LOQ. LOD & LOQ were found to be 0.2326μ g/ml & 0.7252μ g/ml respectively.


Rabari H.,Veerayatan Institute of Pharmacy | Pandya S.,Pharmacy College | Vidyasagar G.,Veerayatan Institute of Pharmacy | Gajra B.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2010

The chloroform and ethyl acetate extracts of leaves of Cocculus pendulus, were tested for anti-inflammatory and wound healing activity at the doses of 200 and 400 mg/kg body weight. Both the extracts at the dose of 400 mg/kg body weight, produced dose dependent and significant inhibition of carrageenan induced paw edema. The exhibited anti-inflammatory activity was comparable with the standard drug aspirin. The wound healing activity was evaluated by using excision wound model of rat. The percentage of wound contraction was found to be significant in animals treated with chloroform extract and ethyl acetate extract when compared to controls. The results were comparable with that of the standard drug povidone iodine ointment. The chloroform and ethyl acetate extract treated wounds were found to epithelize faster as compared to controls.


Mittal M.,Jaipur National University | Sarode S.M.,Jaipur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

As a part of systematic investigation for synthesis, characterization and biological activity of several new substituted tricyclic compounds: 7-(phenylsulfonyl)-N-(phenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidin-4-amine (7a-7t) have been synthesized from 7-(phenylsulfonyl)-4-(chloro)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidine (6a-6e) using piperidin-4-one Hydrochloride and benzenesulfonyl chloride as the starting material. All the synthesized products were evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteria and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride fungi respectively. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.


Desai S.,Jodhpur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy | Bhandhari A.,Jodhpur National University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The purpose of this research was to formulate and systematically evaluate in vitro performances of mucoadhesive Midazolam microspheres for the nose to brain delivery and with the aim to avoid first pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form and to improve the therapeutic efficacy of Midazolam. Midazolam microspheres were prepared by emulsion cross linking technique using Carbopol 934P and Hydroxy propyl methyl cellulose (HPMC) K4M as mucoadhesive polymers. Glutaraldehyde was used as a cross-linking agent. The prepared microspheres were evaluated with respect to the particle size, encapsulation efficiency, shape and surface properties, mucoadhesive property, in vitro drug release, Thermal Analysis & X-Ray Diffraction Studies. Microspheres both of Carbopol and HPMC were discrete, spherical and free flowing. The best batch exhibited a high drug entrapment efficiency of 93 ± 1.68 % for SD4 and 97± 1.01 for SP5. The drug release was also sustained up to 12 h. The preliminary results show that the drug loaded HPMC microspheres are much more suitable for the delivery of Midazolam to the brain. The polymer- to-drug ratio had a more significant effect. DSC study confirmed that drug is present in the molecular dispersion.

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