Veerayatan Institute of Pharmacy

Kutch, India

Veerayatan Institute of Pharmacy

Kutch, India
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Prasad M.K.C.,ANU | Sagar G.V.,Veerayatan Institute of Pharmacy | Sudhakar P.,ANU
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: A simple, sensitive, accurate, precise HPTLC method developed for the simultaneous estimation of gabapentin and pregabalin in pharmaceutical dosage forms. Method: The chromatographic estimations were performed using pre-coated Silica Gel G60 F254 aluminum sheet (10 x 10 cm), with a thickness layer of 0.2mm as stationary phase. Ethyl Acetate: Methanol: Ammonia (6.0: 4.0: 0.1 v/v) was used as a mobile phase. Results: The method is validated for linearity, range, accuracy, precision, LOQ, system suitability etc., Linearity exhibits at a concentration ranges from 2-12 ng / ml with r2 value 0.993 and 0.992 for gabapentin and pregabalin respectively. Limit on Quantitation values ranges from 0.4609 and 1.624 for gabapentin and pregabalin respectively. The method was found to be accurate with % recovery 99.13% - 101.83% for Gabapentin and 99.00% - 101.00% for Pregabalin. The method was found to be precise with % CV 1.08 - 2.89 for intraday (n=3) and % CV 2.54 - 3.96 for interday (n=3) for Gabapentin and % CV 1.45 - 3.16 for intraday (n=3) and % CV 1.95 - 4.84 for interday (n=3) for Pregabalin. Conclusion: The proposed HPTLC method is accurate, precise, sensitive, selective and rapid and can be used for the routine simultaneous estimation of Gabapentin and Pregabalin in combination.


Trivedi N.D.,Jodhpur National University | Trivedi U.N.,Veerayatan Institute of Pharmacy | Patel M.M.,Kalol Institute of Pharmacy | Patel J.K.,Nootan Pharmacy College | Bhandari A.,Jodhpur Pharmacy College
American Journal of Drug Discovery and Development | Year: 2011

Ranitidine hydrochloride has a short biological half-life (2.1±0.2 h) and 50% absolute bioavailability. Development of sustained release formulation of ranitidine hydrochloride can be advantageous, that can provide prolong gastric retention and increase efficacy of the dosage form. Calculate theoretical release profile from floating matrix tablets of ranitidine and perform the drug excipient interaction study. In vitro dissolution studies, dissolution profiles, drug: polymer ratio, effect of low density copolymer PSDVB on the release profile of chitosan-carbopol 940 floating matrix tablets, geometry on release, effect of diluents were performed. Select the best batch and swelling index, kinetic modeling of drug release, accelerated stability and in vivo study were carried out. No chemical interaction between ranitidine hydrochloride and the polymers used. Result shows loss of integrity with the increase in concentration of carbopol 940. Significant changes in the floating lag time of the formulation with increased amount of co-polymer. With increasing initial tablet radius, the volume of the system and, thus, the amount of drug available for diffusion increases, resulting in increased absolute amounts of drug released. In contrast, the relative surface area of the device decreases and the amount of drug released in%/ time unit decreased. The x-ray and swelling index shows significant result in batch A12. The present investigation shows that the chitosan-carbopol 940 mixed matrices can be used to modify release rates in hydrophilic matrix tablets prepared by direct compression. © 2011 Academic Journals Inc.


Vidya Sagar G.,Veerayatan Institute of Pharmacy | Shaik A.B.,Vignan Pharmacy College
Journal of Chemical and Pharmaceutical Research | Year: 2015

Plants from the natural world are linked with the treatment of different human ailments. This is due to the presence of different classes of chemical constituents. Flavonoids are one such class of natural constituents responsible for the activity of plants. Chalcones are a class of natural open chain flavonoids that are linked by a three carbon spacer between two aromatic rings. Chalcones and their heterocyclic analogues enjoy a range of biological activities such as antimicrobial, antioxidant, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and antiinflammatory activities which makes these compounds as a special attraction for investigation. Additionally the bielectrophilic, ketovinyl chain between the two rings is highly reactive and acts as an important chemical synthon for constructing different five, six and seven membered heterocyclic scaffolds containing different hetero atoms like nitrogen, oxygen and sulfur atoms by abridgment with a variety of binucleophilic reagents. This review highlights on the chemical and biological potentials of chalcones. © 2015, Journal of Chemical and Pharmaceutical Research. All rights reserved.


Maradiya H.K.,Veerayatan Institute of Pharmacy | Pansara V.H.,Nrvekaria Institute Of Pharmacy And Research Center
Indian Journal of Pharmaceutical Sciences | Year: 2013

A simple, accurate, precise and sensitive reverse-phase high-performance liquid chromatography method for the determination of citicoline sodium has been developed and validated. Drug was resolved on a C18 column (Phenomenex Luna, 250×4.6 mm, 10μ), utilizing mobile phase of potassium dihydrogen phosphate buffer and acetonitrile in a ratio of 30:70. Mobile phase was delivered at the flow rate of 1.0 ml/min and detection was carried out at 272 nm. Separation was completed within 2.22 min. Calibration curve was linear with good correlation coefficient (R 2 =0.999) over a concentration range 10-60 μg/ml. Recovery was between 98.84 and 101.76%. Method was found to be reproducible with relative standard deviation for intra and interday precision of <2.0% over the said concentration range. The method was successfully applied to the determination of the citicoline sodium, it can be very useful and an alternate to performing the stability studies.


Desai S.,Jodhpur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy | Bhandhari A.,Jodhpur National University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2012

Gelatin-chitosan mucoadhesive microspheres of midazolam were prepared using the emulsion cross linking method. In vivo CNS drug distribution studies were carried out in albino rats by administering the midazolam microspheres intranasally and midazolam solution intravenously. From the drug levels in plasma and CSF, drug targeting index and drug targeting percentage were calculated. Results obtained indicated that intranasally administered midazolam microspheres resulted in higher brain levels with a drug targeting index of 2.12 & drug targeting percentage of 62.52%. Gelatin-chitosan cross linked mucoadhesive microspheres have the potential to be developed as a brain-targeted drug delivery system for midazolam.


Karunakar B.,National PG College Nandyala | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The present paper deals with hydro distillation of Achyranthus aspera seeds and GC-MS analysis. The total composition of the oil was 76.7%. The Achyranthus aspera seed volatile oil was tested against pathogenic bacteria and Fungi.


Kumar G.G.,Suresh Gyan Vihar University | Gali V.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

Medicinal plants have been used in all cultures throughout history. Extensive scientific documentation now exists concerning their use for health conditions including many disorders. Medicinal plants are of great importance to the health of individuals and communities. Hence the Author proposes to screen the some above mentioned drugs. The present paper deals with the screening of various phytochemical present in various extract viz., Methanol (80%), Distilled water with chloroform (2.5%) of Abutilon muticum (Del.ex DC.) and Celosia argentea Linn.


Padmalatha H.,University of Rajasthan | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

Quantitative estimation of Candesartan was carried out by UV spectrophotometry using methanol as solvent. The task was performed at 212nm (λmax). Beer's law range was found to be 2-12 μ g/ml. This method was validated as per ICH guidelines by using several parameters like accuracy, precision, linearity, LOD &LOQ. LOD & LOQ were found to be 0.2326μ g/ml & 0.7252μ g/ml respectively.


Mittal M.,Jaipur National University | Sarode S.M.,Jaipur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

As a part of systematic investigation for synthesis, characterization and biological activity of several new substituted tricyclic compounds: 7-(phenylsulfonyl)-N-(phenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidin-4-amine (7a-7t) have been synthesized from 7-(phenylsulfonyl)-4-(chloro)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidine (6a-6e) using piperidin-4-one Hydrochloride and benzenesulfonyl chloride as the starting material. All the synthesized products were evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteria and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride fungi respectively. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.


Desai S.,Jodhpur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy | Bhandhari A.,Jodhpur National University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The purpose of this research was to formulate and systematically evaluate in vitro performances of mucoadhesive Midazolam microspheres for the nose to brain delivery and with the aim to avoid first pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form and to improve the therapeutic efficacy of Midazolam. Midazolam microspheres were prepared by emulsion cross linking technique using Carbopol 934P and Hydroxy propyl methyl cellulose (HPMC) K4M as mucoadhesive polymers. Glutaraldehyde was used as a cross-linking agent. The prepared microspheres were evaluated with respect to the particle size, encapsulation efficiency, shape and surface properties, mucoadhesive property, in vitro drug release, Thermal Analysis & X-Ray Diffraction Studies. Microspheres both of Carbopol and HPMC were discrete, spherical and free flowing. The best batch exhibited a high drug entrapment efficiency of 93 ± 1.68 % for SD4 and 97± 1.01 for SP5. The drug release was also sustained up to 12 h. The preliminary results show that the drug loaded HPMC microspheres are much more suitable for the delivery of Midazolam to the brain. The polymer- to-drug ratio had a more significant effect. DSC study confirmed that drug is present in the molecular dispersion.

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