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Mittal M.,Jaipur National University | Sarode S.M.,Jaipur National University | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

As a part of systematic investigation for synthesis, characterization and biological activity of several new substituted tricyclic compounds: 7-(phenylsulfonyl)-N-(phenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidin-4-amine (7a-7t) have been synthesized from 7-(phenylsulfonyl)-4-(chloro)-5,6,7,8-tetrahydropyrido[4',3':4,5]-thieno [2,3-d]pyrimidine (6a-6e) using piperidin-4-one Hydrochloride and benzenesulfonyl chloride as the starting material. All the synthesized products were evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteria and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride fungi respectively. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data. Source

Padmalatha H.,University of Rajasthan | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

Quantitative estimation of Candesartan was carried out by UV spectrophotometry using methanol as solvent. The task was performed at 212nm (λmax). Beer's law range was found to be 2-12 μ g/ml. This method was validated as per ICH guidelines by using several parameters like accuracy, precision, linearity, LOD &LOQ. LOD & LOQ were found to be 0.2326μ g/ml & 0.7252μ g/ml respectively. Source

Karunakar B.,National PG College Nandyala | Vidyasagar G.,Veerayatan Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The present paper deals with hydro distillation of Achyranthus aspera seeds and GC-MS analysis. The total composition of the oil was 76.7%. The Achyranthus aspera seed volatile oil was tested against pathogenic bacteria and Fungi. Source

Vidya Sagar D.,Veerayatan Institute of Pharmacy | Shaik A.B.,Andhra University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Pyrimidine derivatives are a group of heterocyclic compounds which are associated with a wide variety of biological activities. Broad spectrum of biological activities of pyrimidine derivatives elated to synthesize a series of some new different pyrimidine derivatives by condensation of different chalcones with guanidine hydrochloride in the presence of potassium hydroxide as catalyst. The synthesized pyrimidine derivatives were purified by either recrystallization or column chromatographic techniques. The characterization of the purified pyrimidine derivatives was done by IR, 1H NMR spectral data and elemental analysis. These compounds were further screened for anti-inflammatory and cytotoxic activities using standard protocols. When these pyrimidine derivatives were evaluated for anti-inflammatory and cytotoxic activities some of them found to possess significant biological activity when compared to standard drugs. Source

Kumar G.G.,Suresh Gyan Vihar University | Gali V.,Veerayatan Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2011

Medicinal plants have been used in all cultures throughout history. Extensive scientific documentation now exists concerning their use for health conditions including many disorders. Medicinal plants are of great importance to the health of individuals and communities. Hence the Author proposes to screen the some above mentioned drugs. The present paper deals with the screening of various phytochemical present in various extract viz., Methanol (80%), Distilled water with chloroform (2.5%) of Abutilon muticum (Del.ex DC.) and Celosia argentea Linn. Source

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