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Patel S.,Veer Surendra Sai Institute of Medical science and Research | Dehury S.,Veer Surendra Sai Institute of Medical science and Research | Purohit P.,Veer Surendra Sai Institute of Medical science and Research | Meher S.,Veer Surendra Sai Institute of Medical science and Research | Das K.,Veer Surendra Sai Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2015

Hereditary persistence of foetal haemoglobin (HPFH) is a rare inherited haemoglobin disorders in India. We encountered five cases of HPFH-3 in heterozygous condition in a single family of western Odisha, India. All the cases had raised % HbF (26.1±3.23%) with pancellular distribution of HbF in erythrocytes. There were no abnormalities found in the red cell indices. All the cases were asymptomatic till date with normal growth and development. Molecular confirmation of this haemoglobin disorders is important for control and prevention of haemoglobinopathies in this region. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Mohapatra M.K.,Veer Surendra Sai Institute of Medical science and Research | Behera A.K.,Veer Surendra Sai Institute of Medical science and Research | Karua P.C.,Veer Surendra Sai Institute of Medical science and Research | Bariha P.K.,Veer Surendra Sai Institute of Medical science and Research | And 4 more authors.
Clinical Kidney Journal | Year: 2016

Background: Severe cholestatic jaundice may complicate with bile cast nephropathy (BCN) causing severe acute kidney injury (AKI). In this study, we investigate BCN in severe falciparum malaria complicated with jaundice and AKI. Methods: This prospective study was conducted in a tertiary health care institution with high prevalence ofmalaria. A cohort of 110 patients with falciparum malaria complicated with cerebralmalaria, jaundice and AKI were enrolled. Species diagnosis was made fromperipheral blood smear or rapid diagnostic test. Severemalariawas diagnosed fromWHO criteria. BCNwas diagnosed with the detection of bile casts in urine or in biopsy. The recovery pattern and outcome with and without BCN was assessed. Results: Out of 110 patients, 20 (18.2%) patients had BCN and 15 (13.6%) patients had hepato-renal syndrome. Patients with BCN had high conjugated bilirubin (26.5 ± 4.1 mg/dL), urea (75.9 ± 10.3 mg/dL) and creatinine (7.2 ± 0.8 mg/dL), longer duration of illness (6.4 ± 1.1 days), higher mortality (25.0%) and prolonged recovery time of hepatic (9.6 ± 2.4 days) and renal dysfunction (15.1 ± 6.5 days) compared with patients without BCN. Conclusions: Prolonged duration of illness and increased bilirubin cause BCN among patients with severe falciparum malaria with jaundice and AKI, which is associated with high mortality and morbidity. © The Author 2016.


PubMed | Veer Surendra Sai Institute of Medical science and Research
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Hereditary persistence of foetal haemoglobin (HPFH) is a rare inherited haemoglobin disorders in India. We encountered five cases of HPFH-3 in heterozygous condition in a single family of western Odisha, India. All the cases had raised % HbF (26.13.23%) with pancellular distribution of HbF in erythrocytes. There were no abnormalities found in the red cell indices. All the cases were asymptomatic till date with normal growth and development. Molecular confirmation of this haemoglobin disorders is important for control and prevention of haemoglobinopathies in this region.

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