Thousand Oaks, CA, United States

VecTOR Test Systems, Inc

www.vectortest.com
Thousand Oaks, CA, United States
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Hinson J.M.,U.S. Army | Dave S.,VecTOR Test Systems, Inc | McMenamy S.S.,U.S. Army | Dave K.,VecTOR Test Systems, Inc | Turell M.J.,U.S. Army
Journal of Medical Entomology | Year: 2015

The outbreak of disease caused by chikungunya virus (CHIKV) in 2006 and the recent spread of this virus to the Americas in 2013 indicate the potential for this virus to spread and cause significant disease. However, there are currently no accurate and reliable field-usable, diagnostic methods to provide critical, real-time information for early detection of CHIKV within the vector populations in order to implement appropriate vector control and personal protective measures. In this article, we report the ability of an immuno-chromatographic assay developed by VecTOR Test Systems Inc. to detect CHIKV in a pool of female Aedes mosquitoes containing a single CHIKV-infected mosquito. The CHIKV dipstick assay was simple to use, did not require a cold chain, and provided clear results within 1 h. It was highly specific and did not cross-react with samples spiked with a variety of other alpha, bunya, and flaviviruses. The CHIKV assay can provide real-time critical information on the presence of CHIKV in mosquitoes to public health personnel. Results from this assay will allow a rapid threat assessment and the focusing of vector control measures in high-risk areas. © 2015, Oxford University Press. All rights reserved.


PubMed | U.S. Army and VecTOR Test Systems, Inc
Type: Journal Article | Journal: Journal of medical entomology | Year: 2015

The outbreak of disease caused by chikungunya virus (CHIKV) in 2006 and the recent spread of this virus to the Americas in 2013 indicate the potential for this virus to spread and cause significant disease. However, there are currently no accurate and reliable field-usable, diagnostic methods to provide critical, real-time information for early detection of CHIKV within the vector populations in order to implement appropriate vector control and personal protective measures. In this article, we report the ability of an immuno-chromatographic assay developed by VecTOR Test Systems Inc. to detect CHIKV in a pool of female Aedes mosquitoes containing a single CHIKV-infected mosquito. The CHIKV dipstick assay was simple to use, did not require a cold chain, and provided clear results within 1h. It was highly specific and did not cross-react with samples spiked with a variety of other alpha, bunya, and flaviviruses. The CHIKV assay can provide real-time critical information on the presence of CHIKV in mosquitoes to public health personnel. Results from this assay will allow a rapid threat assessment and the focusing of vector control measures in high-risk areas.


Grant
Agency: Department of Defense | Branch: Defense Health Program | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2015

VecTOR Test Systems, Inc will develop assay for rapid detection of the Lyme disease pathogen Borrelia burgdorferi in ticks in a field setting. In Phase I, feasibility of the concept will be determined by developing a prototype assay that has the potential to detect Borrelia burdorferi. The overall objective is to develop product/s that will quickly and accurately determine whether arthropods collected by preventive medicine units in the field are infected with medically relevant pathogens in order to minimize the impact of the disease on operational capabilities. The technology is based on the simple and reliable immuno-chromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret requiring limited resources. The assay will be an important addition to the range of vector test products that detect the pathogens in the vectoring arthropods. The developed assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 692.83K | Year: 2012

VecTOR Test Systems, Inc will develop assays that can detect a broad range of alphaviruses and a broad range of flaviviruses in arthropod pools in a field setting. In Phase I, feasibility of the concept was determined by successfully developing prototype assays that can detect in a single multiplex format and as two group specific tests various alphaviruses and flaviviruses. The overall objective is to develop product/s that will quickly and accurately determine whether arthropods collected by preventive medicine units in the field are infected with medically relevant alphaviruses or flaviviruses in order to minimize the impact of the disease on operational capabilities. In Phase II, research will continue to select and finalize reagents that will allow development of tests with required sensitivity and specificity. These tests will provide results in less than 30 minutes and be interpreted visually as well as with a battery operated reader for quantitative comparison and storing of results. The assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be developed rugged to withstand field storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.98K | Year: 2010

VecTOR Test Systems, Inc. proposes to develop an assay to quickly determine, in a non-laboratory and minimal resource environment, whether sand flies collected in specific areas of a military deployment are infected with either L. major or L. infantum. The proposed assays will be performed in a rapid, one-step immuno-chromatographic process for detection of Leishmania sp such as L. major, and L infantum in infected sand-flies. These are the most ubiquitous species of Leishmania found in many parts of the mid-east. Leishmania is not prevented by vaccines or prophylactic drugs so prevention relies on personal protective measures and vector control measures that need to be targeted to be effective at reducing disease risk. The proposed dipstick assays will provide results within 30 minutes and will be stable at ambient storage conditions. Assays developed in similar format for other arthropod vectors e.g. the mosquito vector for detection of Malaria circumsporozoite proteins, WNV, SLE, EEE, and WEE and have found commercial application. The development of easy to use tests will be important for detection of pathogens of military importance and will be useful in the commercial sector for vector surveillance and control programs.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.95K | Year: 2010

VecTOR Test Systems, Inc. will develop a rapid multiplexed detection hand-held assay capable of simultaneously determining whether mosquitoes are infected with CHIKV, WNV, and/or Dengue. Developed tests will quickly and accurately determine whether mosquitoes are infected with CHIKV, WNV, and/or Dengue, to minimize the impact of the disease. The technology is based on the simple and reliable immunochromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 70.00K | Year: 2010

VecTOR Test Systems, Inc. proposes to develop a hand-held, field-deployable multiplex assay capable of detecting and identifying TBEV, CCHFV, and/or Rickettsia in ticks collected from deployed military service areas. The proposed dipstick assays will provide results within 30 minutes and will be stable at ambient storage conditions. Assays developed in similar format for other arthropod vectors e.g. the mosquito vector for detection of Malaria circumsporozoite proteins, WNV, SLE, EEE, and WEE and have found commercial application. The development of easy to use tests will be important for detection of pathogens of military importance and will be useful in the commercial sector for vector surveillance and control programs.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 729.99K | Year: 2010

Rift Valley fever is a mosquito-borne viral disease that is a significant threat to human and livestock. VecTOR Test Systems, Inc. will develop a point-of-care assay for detection of Rift Valley Fever virus (RVFV) infection in deployed military service members. In Phase I prototypes were developed and evaluated to demonstrate successful feasibility of detection of RVFV antigen and RVFV-specific IgM and IgG in control samples. In Phase II, development of the product with required sensitivity and specificity performance will be completed. The tests will be laboratory and field evaluated to collect data for application to the U.S. Food and Drug Administration. The developed POC test will aid in the diagnosis of infected personnel. The technology is based on the simple and reliable immunochromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 579.91K | Year: 2010

In this project, VecTOR Test Systems, Inc (VTS) will complete the development and commercialize Rapid Diagnostic Devices (RDD) capable of detecting dengue (DEN) and Rift Valley fever (RVF) viruses in mosquitoes. In addition, VTS will develop a prototype RDD for the detection of RVF virus in veterinary samples. VTS will optimize down-selected DEN and RVF virus assays in order to ensure assays meet requirements. Upon successful completion of independent developmental (laboratory) test and evaluation (DT & E), VTS will provide sufficient number of assays to conduct independent operational (field) test and evaluation (OT & E) required to validate the performance of the assay. Success in performance will allow Armed Forces Pest Management Board to recommend assignment of National Stock Numbers for the Dengue and RVF virus vector tests. RVF virus veterinary assay will detect presence of antigen and RVFV-specific antibody in animal tissue, sera and blood including samples derived from aborted fetuses and slaughtered animals.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 70.00K | Year: 2011

VecTOR Test Systems, Inc will develop assays that can detect a broad range of alphaviruses and a broad range of flaviviruses in arthropod pools in a field setting. In Phase I, feasibility of the concept will be determined by developing a prototype assay(s) that has the potential to detect in a single multiplex format or as two group specific tests, at least three of the alphaviruses and at least two of the flaviviruses. The overall objective is to develop product/s that will quickly and accurately determine whether arthropods collected by preventive medicine units in the field are infected with medically relevant alphaviruses or flaviviruses in order to minimize the impact of the disease on operational capabilities. The technology is based on the simple and reliable immuno-chromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions.

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