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Thousand Oaks, CA, United States

Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 69.99K | Year: 2009

Sand fly fever viruses (SFFV) are a significant health problem in many regions of the world, such as Africa, the Mediterranean basin, the Middle East and Central Asia. SFFV are transmitted by sand fly vectors (Phlebotomus spp.). VecTOR Test Systems, Inc. will develop a point-of-care assay for detection of SFFV infection in deployed military service members. The assay capable of detecting SFFV antigen as well as specific IgM response in clinical samples will aid in the diagnosis of infected personnel. The technology is based on the simple and reliable immuno-chromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions. In Phase I, a sufficient number of assays will be manufactured to evaluate performance and determine plan for the next phase.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 692.83K | Year: 2012

VecTOR Test Systems, Inc will develop assays that can detect a broad range of alphaviruses and a broad range of flaviviruses in arthropod pools in a field setting. In Phase I, feasibility of the concept was determined by successfully developing prototype assays that can detect in a single multiplex format and as two group specific tests various alphaviruses and flaviviruses. The overall objective is to develop product/s that will quickly and accurately determine whether arthropods collected by preventive medicine units in the field are infected with medically relevant alphaviruses or flaviviruses in order to minimize the impact of the disease on operational capabilities. In Phase II, research will continue to select and finalize reagents that will allow development of tests with required sensitivity and specificity. These tests will provide results in less than 30 minutes and be interpreted visually as well as with a battery operated reader for quantitative comparison and storing of results. The assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be developed rugged to withstand field storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.98K | Year: 2010

VecTOR Test Systems, Inc. proposes to develop an assay to quickly determine, in a non-laboratory and minimal resource environment, whether sand flies collected in specific areas of a military deployment are infected with either L. major or L. infantum. The proposed assays will be performed in a rapid, one-step immuno-chromatographic process for detection of Leishmania sp such as L. major, and L infantum in infected sand-flies. These are the most ubiquitous species of Leishmania found in many parts of the mid-east. Leishmania is not prevented by vaccines or prophylactic drugs so prevention relies on personal protective measures and vector control measures that need to be targeted to be effective at reducing disease risk. The proposed dipstick assays will provide results within 30 minutes and will be stable at ambient storage conditions. Assays developed in similar format for other arthropod vectors e.g. the mosquito vector for detection of Malaria circumsporozoite proteins, WNV, SLE, EEE, and WEE and have found commercial application. The development of easy to use tests will be important for detection of pathogens of military importance and will be useful in the commercial sector for vector surveillance and control programs.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.95K | Year: 2010

VecTOR Test Systems, Inc. will develop a rapid multiplexed detection hand-held assay capable of simultaneously determining whether mosquitoes are infected with CHIKV, WNV, and/or Dengue. Developed tests will quickly and accurately determine whether mosquitoes are infected with CHIKV, WNV, and/or Dengue, to minimize the impact of the disease. The technology is based on the simple and reliable immunochromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be easy to perform and results easy to interpret in far-forward situations. The assay will be made available in a kit with components required to perform the assay. The assay kit will be stable at ambient storage conditions.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 70.00K | Year: 2010

VecTOR Test Systems, Inc. proposes to develop a hand-held, field-deployable multiplex assay capable of detecting and identifying TBEV, CCHFV, and/or Rickettsia in ticks collected from deployed military service areas. The proposed dipstick assays will provide results within 30 minutes and will be stable at ambient storage conditions. Assays developed in similar format for other arthropod vectors e.g. the mosquito vector for detection of Malaria circumsporozoite proteins, WNV, SLE, EEE, and WEE and have found commercial application. The development of easy to use tests will be important for detection of pathogens of military importance and will be useful in the commercial sector for vector surveillance and control programs.

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