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Pathania M.,VCSG Government Medical science and Research Institute
BMJ case reports

A pregnant woman, in her early 20s, presents with chorea following an emotional outburst. While the family members feel it to be a spirit haunting her, we try to establish the medical diagnosis of the present condition. There is a history of rheumatic fever in the past and examination reveals choreioathetoid jerky movements of her upper limbs with jerky speech, spooning of her limbs and demonstration of milkmaid's grip. Laboratory investigations did not reveal anything interesting. We discuss the diagnosis and management of this patient. Source

Garg R.,VCSG Government Medical science and Research Institute | Goyal S.,Uttrakhand Dental Clinic | Gupta S.,Mahatma Gandhi Institute
Maternal and Child Health Journal

The onset of menstruation is one of the most important physiological changes occurring among girls during the adolescent years. Menstruation heralds the onset of physiological maturity in girls. It becomes the part and parcel of their lives until menopause. Apart from personal importance, this phenomenon also has social significance. In India, menstruation is surrounded by myths and misconceptions with a long list of "do's" and "don'ts" for women. Hygiene-related practices of women during menstruation are of considerable importance, as it may increase vulnerability to Reproductive Tract Infections (RTI's). Poor menstrual hygiene is one of the major reasons for the high prevalence of RTIs in the country and contributes significantly to female morbidity. Most of the adolescent girls in villages use rags and old clothes during menstruation, increasing susceptibility to RTI's. Adolescents constitute one-fifths of India's population and yet their sexual health needs remain largely unaddressed in the national welfare programs. Poor menstrual hygiene in developing countries has been an insufficiently acknowledged problem. In June 2010, the Government of India proposed a new scheme towards menstrual hygiene by a provision of subsidized sanitary napkins to rural adolescent girls. But there are various other issues like awareness, availability and quality of napkins, regular supply, privacy, water supply, disposal of napkins, reproductive health education and family support which needs simultaneous attention for promotion of menstrual hygiene. The current article looks at the issue of menstrual hygiene not only from the health point of view, but also considers social and human rights values attached to it. © Springer Science+Business Media, LLC 2012. Source

Mukherjee S.,VCSG Government Medical science and Research Institute | Gogoi J.B.,VCSG Government Medical science and Research Institute
Current Chemical Biology

Free radicals and oxidants play a dual role as both toxic and beneficial compounds, which in low/moderate concentrations are involved in normal physiological functions but excess production of free radicals or decrease in antioxidant level leads to oxidant stress. Free radicals are produced either from normal cell metabolisms in situ or from different external sources (pollution, cigarette smoke, radiation, medication etc). When an overload of free radicals cannot gradually be destroyed, their accumulation in the body is a harmful process that can mediate damage to cellular structures, including lipids, proteins, RNA and DNA leading to a number of diseases. ROS (reactive oxygen species) and RNS (reactive nitrogen species) in excess can damage biological processes, and this situation has been observed in various acute and chronic diseases such as cancer, autoimmune disorders, aging, cataract, cardiovascular and neurodegenerative diseases. This review deals in depth with the role of free radical generation, the mechanisms of formation and catabolism, and the role in various diseases and the function of different phytoconstituents as a defensive factor in the treatment of diseases caused by free radicals, as in the new era they are conferring less side effects and are compatible to body physiology. © 2011 Bentham Science Publishers. Source

Pathania M.,VCSG Government Medical science and Research Institute
BMJ case reports

The clinical presentation of an adolescent man with left lung hypoplasia is described in detail including the history and clinical examination findings. On further investigation, the chest x-ray and CT scan of the chest reveal interesting findings. Generally, such conditions are brought to notice in the early years of life but the presentation of this condition at the age of 18 years make it even more interesting and unique. This is a discussion of the management of such a patient and the different types of lung hypoplasia which can be encountered in clinical practice. Source

Joshi A.K.,VCSG Government Medical science and Research Institute | Joshi C.,VCSG Government Medical science and Research Institute | Singh S.,IMS | Singh V.,VCSG Government Medical science and Research Institute

Background: Traumatic loss of talus during a compound injury of ankle is an unusual injury. Objective: We report a 55 years old woman who sustained an open ankle injury with complete extrusion of talus and loss at the injury site. Method: A tricortical bone graft was obtained from iliac crest and talar dimensions carved with 5. cm length and 3. cm height given by buttressing fibular graft between them. These grafts are made in the shape of talus by fixing them together with cortical screw and binding them together with Ethibond No. 5. By anterior approach ankle was opened and talar graft was placed in between the raw surfaces of tibia and calcaneus to facilitate ankle arthrodesis. Result: Patient had solid fusion at the ankle joint after 4 months with no pain on walking. Conclusion: The definitive treatment of this serious lower extremity injury remains controversial we have attempted this novel way of treatment as the patient was unable to afford talar prosthesis and facilities of allogenic bone grafts were not there. © 2012 Elsevier Ltd. Source

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