Yu S.-C.,Kuang Tien General Hospital |
Kuo C.-L.,Vascular and Genomic Center |
Huang C.-S.,Vascular and Genomic Center |
Chang C.-S.,Vascular and Genomic Center |
And 8 more authors.
Biomarkers | Year: 2012
Granulocyte colony-stimulating factor (G-CSF) may protect ischemic brain injury either in animal or human. No studies have reported that endogenous G-CSF (enG-CSF) level is related to the severity of ischemic stroke. This study was designed to assess the severity of ischemic patients correlated with the alteration of enG-CSF on the 1st day after an ischemic event. Patient's plasma enG-CSF and scoring of National Institute of Health Stroke Scale were measured on the 1st day after ischemic stroke. The acute ischemic stroke could significantly induce enG-GCF secretion as compared with healthy control group (16.77 vs. 22.86 μg/L, p0.001). Elevated enG-CSF concentration was positively correlated with the severity of stroke patients on day 1 after the event (p0.006; Spearman correlation coefficient0.268). The enG-CSF is a good biomarker for prediction of severity of acute ischemic stroke. © 2012 Informa UK, Ltd.