Vardhman Mahavir Medical College and Safdarjung Hospital

Delhi, India

Vardhman Mahavir Medical College and Safdarjung Hospital

Delhi, India
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Sethi H.S.,Vardhman Mahavir Medical College and Safdarjung Hospital | Naik M.P.,Vardhman Mahavir Medical College and Safdarjung Hospital
Journal of Cataract and Refractive Surgery | Year: 2017

We describe a technique for suture-guided sulcus implantation of a foldable acrylic posterior chamber IOL (PC IOL). A 10-0 monofilament nylon suture is used to control insertion of the PC IOL over the ciliary sulcus and enable safe retrieval if the PC IOL drops during insertion, stabilization, or centration. In this technique, the 10-0 monofilament nylon suture acts as a guy rope to hold onto the PC IOL, enabling the surgeon to inject the IOL into the sulcus, unfold it in the iris plane, dial it in the appropriate meridian, and stabilize it. © 2017 ASCRS and ESCRS

Vaccine vial monitor (VVM) is now commonly used for vaccines that are included in the National Immunization Schedule in India. It helps to indicate the viability of the vaccine and of the proper functioning of the cold chain. This is useful as it prevents health personnel from administering damaged vaccine. Studies have shown a lack of awareness of health workers regarding the use and interpretation of a VVM. The current study, undertaken among the caregivers of children who were immunized, showed that this lack of information about the VVM also exists among the caregivers. This deficiency in knowledge, both in the health workers and the caregivers, can affect the health of the child and needs urgent attention. © 2017, © The Author(s) 2017.

Ghasi R.G.,Vardhman Mahavir Medical College and Safdarjung Hospital | Bajaj S.K.,Vardhman Mahavir Medical College and Safdarjung Hospital
Indian Journal of Radiology and Imaging | Year: 2017

Lung infections are an important cause of morbidity and mortality, particularly because of the rising antimicrobial resistance. According to the clinical setting, they can be categorized as community-acquired pneumonia and hospital-acquired pneumonia. Radiological patterns of lung infections are lobar consolidation, bronchopneumonia, interstitial pattern, and nodular pattern. In addition, typical imaging features of several infections serve as 'red flag signs' in reaching a diagnosis or altering the management. It would be prudent for the radiologist to be well informed regarding these aspects of lung infections to be able to make a valuable contribution to the management.

Bala M.,Vardhman Mahavir Medical College and Safdarjung Hospital | Kakran M.,Vardhman Mahavir Medical College and Safdarjung Hospital | Singh V.,Vardhman Mahavir Medical College and Safdarjung Hospital | Sood S.,AIIMS | Ramesh V.,Vardhman Mahavir Medical College and Safdarjung Hospital
Sexually Transmitted Infections | Year: 2013

Objective The aim of the present study was to retrospectively analyse the data reported on antimicrobial resistance (AMR) in Neisseria gonorrhoeae in six South- East Asia Region countries from 2009 to 2012 following the revitalisation of the WHO global Gonococcal Antimicrobial Surveillance Program (GASP). Methods AMR data were generated for 7 antibiotics of 4675 isolates in 18 focal point laboratories using the calibrated dichotomous sensitivity (CDS) or Clinical and Laboratory Standards Institute (CLSI) methods and minimal inhibitory concentration testing by Etest in some of the centres. The results were interpreted using the breakpoints recommended. Results High-level resistance to traditional antibiotics, penicillin (25% to 100%) and tetracycline (10% to 100%) and the previously recommended ciprofloxacin (38% to 100%) was observed in all the countries. Overall, <90% of less susceptible and resistant isolates to penicillin and ciprofloxacin were identified from 15 laboratories. Decreased susceptibility to ceftriaxone and cefpodoxime was reported by nine and eight centres, respectively. Resistance to spectinomycin (0.6% to 10.5%) and azithromycin (>5%) was reported only by three centres. The increasing trends of resistance towards penicillin, tetracycline and ciprofloxacin were demonstrated in Bhutan, India, Sri Lanka and Thailand, and no large intercountry variations were evident. Insignificant trends in decreased susceptibility towards ceftriaxone were reported. Conclusions Expansion of the WHO GASP facilitated enhanced AMR surveillance to meet the ongoing challenges of control of gonococcal AMR. The results highlight that the emergence of decreased susceptibility to ceftriaxone and resistance to spectinomycin and azithromycin will unavoidably lead to loss of therapeutic options, and a search for new effective agents needs to be initiated to respond to the emergence of resistant isolates.

Agarwal K.A.,Vardhman Mahavir Medical College and Safdarjung Hospital | Tripathi C.D.,Safdarjung Hospital | Agarwal B.B.,Dr. Agarwals Surgery and Yoga | Saluja S.,Sir Ganga Ram Hospital
Surgical Endoscopy and Other Interventional Techniques | Year: 2011

Objective: Better patient-reported outcomes (PROs) of laparoscopic cholecystectomy (LC) are premised upon PROs such as postoperative pain and fatigue. These PROs are indices of convalescence and return to normal activity. Curcumin (turmeric) is used in India for traumatic pain and fatigue for its anti-inflammatory/antioxidant and tissue modulation/healing properties. We studied the effect of curcumin on pain and postoperative fatigue in patients of LC. Methods and procedures: From July to September 2009, 50 consecutive day-care LC candidates were enrolled for a prospective, double-blind randomized placebo-controlled study. A uniform general anesthesia and analgesia protocol was followed. Curcumin/placebo and rescue analgesic were prescribed at discharge. Patients were told to maintain pain/fatigue/adverse event diaries based upon 100-point visual analog pain scale (VAS) and 10-point interval rating fatigue scale (IRS). Patients were followed up at third day (D3), first week (W1), second week (W2), and third week (W3). The blind labels were opened at the end of study. Results: Demographic characteristics, comorbidity, and gallbladder pathology profiles were comparable in the study (n = 25) and control groups (n = 25). There was no adverse surgical outcome, adverse PRO or withdrawal. Pain and fatigue scores at D3 were similar in the two groups. At W1 and W2, the study group showed significantly lower (p value 0.000) mean pain scores, i.e., 15 ± 5.204 versus 30 ± 13 in controls. Fatigue scores at W1, W2, and W3 were significantly lower (p value 0.000) in the study group, i.e., 2.16 ± 1.748, 1, and 0, respectively, versus 5.16 ± 1.375, 4.20 ± 1.633, and 1 in controls. All patients were pain free at W3. Analgesic tablet usage was significantly lower (p value 0.000) in the study group, i.e., 6.96 ± 1.837 versus 39.32 ± 16.509 in controls. Conclusions: Turmeric (curcumin) improves postoperative pain- and fatigue-related PROs following LC. © 2011 Springer Science+Business Media, LLC.

Khokhar A.,Vardhman Mahavir Medical College And Safdarjung Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2013

There is a consensus among researchers about the fact that women should be familiar with their breasts but there is a lot of argument as to how to make them aware of what is normal for them. For over decades breast self examination (BSE) was advocated for the same but as an outcome of work conducted by researchers in various countires a controversy has been raised in the West. In a country like India, where breast cancer screening is not popular and limited resources are available we should question what would be the best strategy to make women familiar with their breasts to facilitate best use of BSE.

Singh D.,Vardhman Mahavir Medical College and Safdarjung Hospital
Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association | Year: 2013

Simultaneous fracture/dislocation of the thumb carpometacarpal (CMC) joint and dislocation of the metacarpophalangeal (MCP) joint is considered as a rare injury pattern. We report an unusual case of dorsal dislocation of MCP joint of the thumb associated with extraarticular fracture of the base of the first metacarpal in a 28-year-old man. The dislocation of MCP joint had been missed during initial presentation at a peripheral centre. The patient made an uneventful recovery following open reduction and fixation with 1.25 mm Kirschner wire of the MCP joint along with repair of the ulnar collateral ligament. This injury pattern has not been previously reported to the best of our knowledge in the English-language based medical literature.

Khokhar A.,Vardhman Mahavir Medical College and Safdarjung Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2012

A cross-sectional study was conducted among nursing staff of a missionary hospital of Delhi in June 2009. All the nurses were invited to participate in the training programme on breast cancer and techniques of breast self examination (BSE). A questionnaire was administered to all 259 participants seeking information on their level of awareness regarding breast cancer and relevant screening guidelines. With the help of 5 training workshops all the nurses were imparted training regarding the most appropriate technique of doing breast self exams. The mean age of the participants was 35.8 years. Out of a total of 259 nursing staff members 77.2% correctly answered all the 10 questions regarding high risk factors for breast cancer and after the training programme this increased to 100% (p<0.05). Only 65.2% of the participants gave correct responses to all the 8 questions regarding correct technique of performing a BSE, which after the training programme increased to 99.3% (p<0.05). At the baseline only 56.8% knew all the three screening methods correctly and after the intervention 98.7% could correctly mark the responses regarding screening (p<0.05). The actual practice of following the screening guidelines amongst the nursing staff was poor. Only 26 (10.03%) had ever done a BSE, none performed it monthly, 58 (22.4%) had ever gone themselves for a CBE and 18 (6. 94%) had ever undergone mammography.

Rath G.,Vardhman Mahavir Medical College and Safdarjung Hospital | Jawanjal P.,Vardhman Mahavir Medical College and Safdarjung Hospital | Salhan S.,Vardhman Mahavir Medical College and Safdarjung Hospital | Nalliah M.,Dr Babasaheb Ambedkar Indian Rotary Cancer Hospital | Dhawan I.,Vardhman Mahavir Medical College and Safdarjung Hospital
American Journal of Reproductive Immunology | Year: 2015

Problem: To determine the role of inactivated GSK3β with respect to Wnt/β-catenin pathway activation in HPV-16/18-associated cervical cancer. Method of study: The expression of active (pGSK3β-Try216), inactive (pGSK3β-Ser9), and c-Myc as well as HPV-16/18 infection was analyzed in cervical intra-epithelial neoplasia (CIN), squamous cell carcinoma (SCCs) and normal by immunohistochemistry and multiplex PCR. The proteins level was also compared with β-catenin and APC expression. Results: The dramatic decrease of pGSK3β-Try216 expression but ectopic overexpression of pGSK3β-Ser9 and c-Myc was observed both in CIN and SCCs samples compared to normal tissues. 57/67 CIN and 132/153 SCCs showed HPV-16 infection, while 3/67 CIN and 4/153 SCCs were harbored with HPV-18 infection. Both the proteins were significantly upregulated in HPV-16 infected cases (P = 0.0001; P = 0.001) and also positively correlated with nuclear β-catenin (P = 0.0001; P = 0.0001). Conclusion: The process of generation of HPV-16-associated cervical tumorigenesis is synergized with GSK3β inactivation and overactivation of Wnt/β-catenin pathway. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Tiwari P.,Vardhman Mahavir Medical College and Safdarjung Hospital
Indian journal of public health | Year: 2010

The objective of present study was to determine the profile and antimicrobial sensitivity pattern of bacteria isolated from various cultures in a tertiary hospital in Delhi. Culture and sensitivity of all blood, urine, pus, and throat sample reports obtained from May 2006 to April 2007 were analyzed from the central microbiology laboratory register. Among 6918 sample reports analyzed, about half (46%) of them were positive. The most commonly bacteria isolated in 35% of positive blood and pus samples was vancomycin-sensitive Staphylococcus aureus. Most common organism isolated in 54% of positive urine samples was imepenem-sensitive Escherichia coli.

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