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Bijnor, India

Jayanand,Shobhit University | Gupta M.,Vardhaman College | Sinha A.,Shobhit University | Insa I.,Shobhit University | Rai D.V.,Shobhit University
Biomedicine (India) | Year: 2014

Introduction: Today when antibiotics are constantly facing newer challenges of mounting side effects, antibiotic resistance (AR) and multidrug resistance (MDR), the scientific community has to meddle with secrets of nature to find possible improved antidotes. Phytochemicals and essential oils of several medicinal plants have been appraised for their antimicrobial and therapeutic disposition.Aim: The present study was carried out to evaluate the efficacy of essential oils of Cymbopogon flexuosus leaves to inhibit common human pathogenic bacteria like Enterobacter aerogenes and Klebsiellapneumonia.Materials and Method: The antibacterial activity of the extracted oil at different concentration (25,50,75,100 ul) was examined against test organisms by agar well diffusion method. Further, the microbial inhibition properties of readymade oil and commercial antibiotic (tetracycline) were also compared with the extracted oil.Reults: The results showed significantly positive outcomes.Conclusion: Therefore, it can be concluded that the C. flexuosus oil extract has substantial antibacterial properties. Source


Kumar G.,Chemical science Laboratory | Devi S.,Vardhman College | Johari R.,Vardhaman College
E-Journal of Chemistry | Year: 2012

M(III) Schiff base macrocyclic complexes of the type [HLMX2] where M = Cr(III), Mn(III), Fe(III) and X = Cl, OAc have been synthesized by condensation of acetylacetone and Thio-carbohydrazide (2:2) in the presence of divalent metal salt in methanolic medium. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers are octahedral. © 2012 Hindawi Publishing Corporation. Source


Kumar G.,Chemical science Laboratory | Johari R.,Vardhaman College | Devi S.,Vardhaman College
E-Journal of Chemistry | Year: 2012

A Schiff base ligand was synthesized by reacting 5-tert-butl-2-hydroxy-3- (3-phenylpent-3-yl) benzaldehyde and thiodihydrazide (2:1) and a series of metal complexes with this new ligand were synthesized by reaction with Cr (III), Mn (III), and Fe (III) metal salt in methanolic medium. The Schiff base ligand and its complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structure configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers were octahedral. IR spectral data suggest that ligand behaves as a tetradentate ligand with ONNO donor sequence towards the metal ion. © 2012 Hindawi Publishing Corporation. Source


Kumar G.,Vardhaman College | Kumar G.,Institute of Chemical Technology | Devi S.,Vardhaman College | Johari R.,Vardhaman College | Kumar D.,Vardhaman College
European Journal of Medicinal Chemistry | Year: 2012

A Schiff base ligand was synthesized by reacting 1,4-dicarbonyl-phenyl- dihydrazide and chromene-2,3-dione (2:2) and a series of metal complexes with this new ligand were synthesized by reaction with Cr (III), Mn (III), and Fe (III) metal salt in methanolic medium. The Schiff base ligand and its metal complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structure configuration has been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic spectra of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential. © 2012 Elsevier Masson SAS. All rights reserved. Source


Kumar G.,P.A. College | Kumar D.,Vardhaman College | Devi S.,Vardhaman College | Kumar A.,P.A. College | Rajeev J.,Vardhaman College
E-Journal of Chemistry | Year: 2010

M(III) complexes with Cr, Mn and Fe with Schiff base derived from 2-amino-4-ethyl-5-hydroxy benzaldehyde and oxocarbohydrazide were synthesized and characterized by several techniques using elemental analysis (C, H, N), molar conductance measurements, magnetic measurements, electronic, mass and IR spectral studies. On the bases of these studies, a five coordinated square pyramidal geometry for all these complexes has been proposed and found to be potential antimicrobial agent. The Schiff base ligand and complexes were also tested for their antimicrobial activity (against the bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus megaterium and the fungi Kluyveromyces fragilis, Rhodotorula rubra, Candida albicans and Trichoderma reesei) to assess their inhibiting potential. An attempt is also made to correlate the antimicrobial activity with geometry of the complexes. All complexes were found to be less active against the pathogens E.coli, S.aureus and P.aeruginosa. Cr(III) complex showed the best antimicrobial activity, but ligand alone was found to be active against the fungus T.reesei. Source

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