Varastegan Institute for Medical Science

Mashhad, Iran

Varastegan Institute for Medical Science

Mashhad, Iran
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Vahid F.,Shahid Beheshti University of Medical Sciences | Shivappa N.,University of South Carolina | Shivappa N.,Connecting Health Innovations, Llc | Karamati M.,Varastegan Institute for Medical science | And 4 more authors.
Applied Physiology, Nutrition and Metabolism | Year: 2017

The possible relationship between diet-related inflammation and the risk of prediabetes requires further investigation, especially in non-Western populations. We examined the ability of the dietary inflammatory index (DII) to predict the risk of prediabetes in a case-control study conducted at specialized centers in Esfahan, Iran. A total of 214 incident cases of prediabetes were selected with the nonrandom sampling procedure, and the 200 controls randomly selected from the same clinics were frequency-matched on age (±5 years) and sex. DII scores were computed based on dietary intake assessed using a validated and reproducible 168-item food-frequency questionnaire. Linear and logistic regression models were used to estimate multivariable beta estimates and odds ratios (ORs). Subjects in tertile 3 versus tertile 1 (T3VS1) of DII had significantly higher fasting plasma glucose (DIIT3VS1: b = 4.49; 95% CI 1.89, 7.09), oral glucose tolerance (DIIT3VS1: b = 8.76; 95% CI 1.78, 15.73), HbA1c (DIIT3VS1: b = 0.30; 95% CI 0.17, 0.42), low-density lipoprotein (DIIT3VS1: b = 16.37; 95% CI 11.04, 21.69), triglyceride (DIIT3VS1: b = 21.01; 95% CI 8.61, 33.42) and body fat (DIIT3VS1: b = 2.41; 95% CI 0.56, 4.26) and lower high-density lipoprotein (DIIT3VS1: b = −3.39; 95% CI −5.94, −0.84) and lean body mass (DIIT3VS1: b = −3.11; 95% CI −4.83, −1.39). After multivariate adjustment, subjects in the most pro-inflammatory DII group had 19 times higher odds of developing prediabetes compared with subjects in tertile 1 (DIIT3VS1: OR= 18.88; 95% CI 7.02, 50.82). Similar results were observed when DII was used as a continuous variable, (DIIcontinuous: OR = 3.62; 95% CI 2.50, 5.22). Subjects who consumed a more pro-inflammatory diet were at increased risk of prediabetes compared with those who consumed a more anti-inflammatory diet. © 2017, Canadian Science Publishing. All rights reserved.


Saljoughian S.,Varastegan Institute for Medical science | Roohinejad S.,Karlsruhe Institute of Technology | Roohinejad S.,Shiraz University of Medical Sciences | Bekhit A.E.-D.A.,University of Otago | And 4 more authors.
Critical Reviews in Food Science and Nutrition | Year: 2017

Essential oils (EO) are complex secondary metabolites, which are produced by aromatic plants and identified by their powerful odors. Present studies on EO and their isolated ingredients have drawn the attention of researchers to screen these natural products and evaluate their effect on the cardiovascular system. Some EO, and their active ingredients, have been reported to improve the cardiovascular system significantly by affecting vaso-relaxation, and decreasing the heart rate and exert a hypotension activity. Several mechanisms have been proposed for the role of EO and their main active components in promoting the health of the cardiovascular system. The objective of this review is to highlight the current state of knowledge on the functional role of EO extracted from plants for reducing the risk of cardiovascular diseases and their mechanisms of action. Research on EO has the potential to identify new bioactive compounds and formulate new functional products for the treatment of cardiovascular diseases such as arterial hypertension, angina pectoris, heart failure, and myocardial infarction. © 2017 Taylor & Francis Group, LLC


Haghshenas S.,Varastegan Institute for Medical science | Hosseini M.S.,Varastegan Institute for Medical science | Aminjan A.S.,University of Tabriz
Psychology and Neuroscience | Year: 2014

Twenty children, aged 10 to 12 years with attention-deficit/hyperactivity disorder (ADHD), were selected to study the effect of vestibular stimulation on auditory perception and sensitivity using the Integrated Visual and Auditory Continuous Performance Test (IVA CPT; a neuropsychological test that is applied in occupational therapy clinics). The present study examined children based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision. After obtaining guardian and parental consent, the children were enrolled in the study and randomly matched according to age across intervention and control groups. The IVA CPT was applied as a pre-test. The children in the intervention group then received vestibular stimulation during therapy sessions twice per week for 10 weeks. The IVA CPT assessment (post-test) was then applied in both groups. The mean pre- and post-test scores were compared across groups. The statistical analyses revealed a significant difference in improvement in auditory comprehension. In conclusion, the present findings suggest that vestibular training is a reliable and powerful treatment option for ADHD, especially when combined with other training. Stimulating the sense of balance highlights the important interaction between inhibition and cognition.


Shariati-Bafghi S.-E.,Varastegan Institute for Medical science | Nosrat-Mirshekarlou E.,Shahid Beheshti University of Medical Sciences | Karamati M.,Varastegan Institute for Medical science | Rashidkhani B.,Shahid Beheshti University of Medical Sciences
International Journal for Vitamin and Nutrition Research | Year: 2015

Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50 - 85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAE Remer ) and Frassetto (based on dietary intakes of protein and potassium; RNAE Frassetto ), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAE Remer and RNAE Frassetto were significantly lower than those in the lowest tertiles (for RNAE Remer: mean difference -0.084 g/cm2 ; P =0.007 and for RNAE Frassetto: mean difference - 0.088 g/cm2 ; P =0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/ day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake. © 2014 Hans Huber Publishers, Hogrefe AG, Bern.


Shivappa N.,University of South Carolina | Hebert J.R.,University of South Carolina | Karamati M.,Varastegan Institute for Medical science | Shariati-Bafghi S.-E.,Varastegan Institute for Medical science | Rashidkhani B.,Shahid Beheshti University of Medical Sciences
European Journal of Nutrition | Year: 2016

Purpose: Diet has been shown to be associated with bone mineral density (BMD); however, the inflammatory potential of diet in modulating BMD has not yet been studied. Methods: We examined the association between a newly developed dietary inflammatory index (DII) and BMD in a sample of postmenopausal Iranian women. In this cross-sectional study, 160 postmenopausal women aged 50–85 years were studied and their femoral neck and lumbar spine BMDs were measured by dual-energy X-ray absorptiometry. The DII was computed based on dietary intake assessed using a previously validated, 168-item semiquantitative food frequency questionnaire. Logistic and linear regression models were fit to derive beta estimates and odds ratios (ORs), with DII fit as continuous and as a dichotomous variable. Results: After adjusting for potential confounders, women with higher DII scores were more likely to have BMD below the median in the lumbar spine with the DII being used as both a continuous variable [ORcontinuous 1.64, 95 % confidence interval (CI) 1.11–2.43, p value = 0.01; one-unit increase corresponding to ≈17 % of its range in the current study] and a categorical variable (ORDII>−0.06/≤ 2.30, 95 % CI 1.05–5.07, p value = 0.04). Similar associations were observed when lumbar spine BMD was used as a continuous outcome. No significant association was observed with BMD in femoral neck, although the direction was along expected lines. Conclusion: These data suggest a pro-inflammatory diet, as indicated by increasing DII score, may be a risk factor for lower BMD in lumbar spine in postmenopausal Iranian women. © 2015, Springer-Verlag Berlin Heidelberg.


PubMed | Varastegan Institute for Medical science, Shahid Beheshti University of Medical Sciences and University of South Carolina
Type: Journal Article | Journal: European journal of nutrition | Year: 2016

Diet has been shown to be associated with bone mineral density (BMD); however, the inflammatory potential of diet in modulating BMD has not yet been studied.We examined the association between a newly developed dietary inflammatory index (DII) and BMD in a sample of postmenopausal Iranian women. In this cross-sectional study, 160 postmenopausal women aged 50-85 years were studied and their femoral neck and lumbar spine BMDs were measured by dual-energy X-ray absorptiometry. The DII was computed based on dietary intake assessed using a previously validated, 168-item semiquantitative food frequency questionnaire. Logistic and linear regression models were fit to derive beta estimates and odds ratios (ORs), with DII fit as continuous and as a dichotomous variable.After adjusting for potential confounders, women with higher DII scores were more likely to have BMD below the median in the lumbar spine with the DII being used as both a continuous variable [ORcontinuous 1.64, 95 % confidence interval (CI) 1.11-2.43, p value = 0.01; one-unit increase corresponding to 17 % of its range in the current study] and a categorical variable (ORDII>-0.06/ 2.30, 95 % CI 1.05-5.07, p value = 0.04). Similar associations were observed when lumbar spine BMD was used as a continuous outcome. No significant association was observed with BMD in femoral neck, although the direction was along expected lines.These data suggest a pro-inflammatory diet, as indicated by increasing DII score, may be a risk factor for lower BMD in lumbar spine in postmenopausal Iranian women.


Fazaeli S.M.,Ferdowsi University of Mashhad | Mahdie R.,Varastegan Institute for Medical Science | Shafaghati Y.,University of Social Welfare and Rehabilitation Sciences
Journal of Mazandaran University of Medical Sciences | Year: 2016

Branchio-oculo-facial (BOF) is a rare genetic disorder inherited as an autosomal dominant trait resulting from maldevelopment in the branchial arches. This paper presents a case of sporadic BOF for the first time in Iran. He was 2 years and 9 months old that was born in the first pregnancy (normal birth). His parents were healthy and they were 3rd degree relatives. The patient had normal intelligence. His obvious symptoms were holes in both sides of the neck (he had surgery at 6 months of age), broad nasal bridge, nasal duct obstruction, pseudocleft of the upper lip, submucos cleft palate, microphthalmia, and squint eye (more dropping in right eye). He also had hypernasal speech. This rare syndrome is accompanied with different anomalies, and physical and mental disorders, therefore, a team of specialists is needed in treatment of such patients. © 2016, Mazandaran University of Medical Sciences. All rights reserved.


Noorbakhsh R.,Ferdowsi University of Mashhad | Noorbakhsh R.,Mashhad University of Medical Sciences | Mortazavi S.A.,Ferdowsi University of Mashhad | Sankian M.,Mashhad University of Medical Sciences | And 4 more authors.
Allergology International | Year: 2010

Background: Tree nut allergy is one of the common potentially life-threatening food allergies in children and adults. Recombinant food allergens offer new perspectives to solve problems of clinical and molecular allergology in diagnosis, research, and therapy of food allergies. So far, superoxide dismutase (s) has been identified as a panallergen and studied in different allergenic sources. Manganese Superoxide Dismutase (MnSOD) has also been reported in pistachio that may cause allergic reactions in atopic subjects. The aim of this study was to describe the cloning, expression, and purification of MnSOD from pistachio nut. Methods: The pistachio MnSOD was cloned and expressed in E. coli BL21 (DE3) using a vector pET-32b (+). A recombinant protein was purified by metal precipitation. The protein immunoreactivity was evaluated using patients' IgE binding by means of ELISA and immunoblotting assays. Results: The MnSOD gene from pistachio was successfully cloned and expressed in E. coli. The purified pistachio MnSOD was recognized by IgE in 10 (40%) out of the 25 sera tested. Our results also showed that this protein might trigger some cross-reactions toward IgE antibodies and thus could be considered as a panallergen. Conclusions: For the first time recombinant manganese superoxide dismutase from nut source was expressed as a possible allergen. This pistachio allergen could be a possible basis for cross-reactivity with MnSOD from other sources. © 2010 Japanese Society of Allergology.


Tehrani M.,Mashhad University of Medical Sciences | Sankian M.,Mashhad University of Medical Sciences | Assarehzadegan M.A.,Ahvaz Jundishapur University of Medical Sciences | Falak R.,Tehran University of Medical Sciences | And 5 more authors.
Allergology International | Year: 2011

Background: Pollinosis from Amaranthus retroflexus pollen is a common cause of respiratory allergy in Iran with a high positive rate (68.8%) among Iranian allergic patients. The aim of the present study was to evaluate the allergenicity of the A. retroflexus pollen profilin. Methods: Using sera from twelve patients allergic to A. retroflexus pollen, IgE-binding proteins from the A. ret-roflexus pollen extract was identified by immunoblotting. The cDNA of A. retroflexus pollen profilin was amplified, then cloned into the pET-21b (+) vector, expressed in Escherichia coli, and finally purified by metal affinity chromatography. The IgE-binding capacity of the recombinant protein was then analyzed by the ELISA, im-munoblotting, and inhibition assays, as well as by the skin prick test (SPT). Results: Immunoblotting results indicated a 14.6 kDa protein with IgE-reactivity to 33% (4/12) among A. retroflexus pollen-allergic patients. Nucleotide sequencing of the cDNA revealed an open reading frame of 399 bp encoding for 133 amino acid residues which was belonged to the profilin family and designated as Ama r 2. A recombinant Ama r 2 (rAma r 2) was then produced in E. coli as a soluble protein which showed a strong IgE-reactivity via ELISA confirmed by the SPT. Inhibition experiments revealed high IgE cross-reactivities with the profilins from other plants. Conclusions: The profilin from the A. retroflexus pollen, Ama r 2, was firstly identified as an allergen. Moreover, rAma r 2 was produced in E. coli as a soluble immunoreactive protein with an IgE-reactivity similar to that of its natural counterpart. © 2011 Japanese Society of Allergology.


PubMed | Varastegan Institute for Medical science
Type: Journal Article | Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition | Year: 2015

Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50-85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAERemer) and Frassetto (based on dietary intakes of protein and potassium; RNAEFrassetto), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAERemer and RNAEFrassetto were significantly lower than those in the lowest tertiles (for RNAERemer: mean difference -0.084 g/cm2; P=0.007 and for RNAEFrassetto: mean difference -0.088 g/cm2; P=0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake.

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