Vanderbilt University is a private research university located in Nashville, Tennessee, United States. Founded in 1873, the university is named in honor of shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided the school its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.Today Vanderbilt enrolls approximately 12,000 students from all 50 U.S. states and over 90 foreign countries in four undergraduate and six graduate and professional schools. Several research centers and institutes are affiliated with the university, including the Vanderbilt Institute for Public Policy Studies, Freedom Forum First Amendment Center, Dyer Observatory, and Vanderbilt University Medical Center, the only Level I trauma center in Middle Tennessee. With the exception of the off-campus observatory and satellite medical clinics, all of university's facilities are situated on its 330-acre campus in the heart of Nashville, 1.5 miles from downtown. Despite its urban surroundings, the campus itself is a national arboretum and features over 300 different species of trees and shrubs. Wikipedia.
Vanderbilt University | Date: 2016-10-26
Method of limiting development of acute kidney injury (AKI) and treating AKI using pyridoxamine are described, together with methods for monitoring efficacy of pyridoxamine therapy.
Vanderbilt University | Date: 2016-06-20
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.
Vanderbilt University | Date: 2016-08-04
An apparatus for moving an elongate rod longitudinally and rotationally, and a method of moving the elongate rod longitudinally and rotationally, are provided. A translation member has a first translation member end held relatively stationary and a longitudinally spaced second translation member end which is selectively movable longitudinally with respect to the first translation member end via actuation of the translation member. The second translation member end is operatively connected to selectively impart longitudinal motion to the elongate rod. A rotation member has a first rotation member end held relatively stationary and a longitudinally spaced second rotation member end which is selectively rotatable with respect to the first rotation member end via actuation of the rotation member. The second rotation member end is operatively connected to selectively impart rotational motion to the elongate rod.
Vanderbilt University | Date: 2016-08-11
A device for manipulating a wire includes a first structure and a second structure pivotably mounted with respect to each other so as to define respective facing surfaces configured for alternating between a closed position and at least one open position, where each of the respective facing surfaces includes one or more detent elements and one or more tooth elements extending therefrom. In the device, the tooth elements of the first structure and the second structure are in an interlocking and overlapping arrangement in at least the closed position. Further, each of the tooth elements has a concave surface for defining a passage between the facing surface in the at least one open position. Additionally, each of the detent elements is arranged to face the concave surface of one of the tooth elements of an opposite one of the respective facing surfaces in the closed position.
Vanderbilt University | Date: 2016-06-23
The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module can include input and output buses; upstream and downstream interconnection bus control valves (CVs) coupled to the input and output buses, respectively. It may include arterial, venous, wash and waste bus lines, each connecting between the upstream and downstream interconnection bus CVs. It may also include an input CV connecting to the arterial bus line, upstream interconnection bus CV, bio-object and inlets, and an output CV connecting to the bio-object, input CV, downstream interconnection bus CV and outlets; and a pump connecting between the input CV and bio-object. The system of fluidic valves and pumps can be arranged to provide MicroFormulator functionality enabling precise mixtures of drugs, chemicals, or biochemicals to be delivered in a time-dependent fashion to biological entities housed in individual wells or chambers.
Vanderbilt University and Yale University | Date: 2016-09-14
Methods, compositions, devices, and kits for treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition are provided. The method of treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition in a subject includes administering an effective amount a miRNA-762 inhibitor to the subject, wherein the subject is identified as having a risk of developing and/or a need for treatment of the condition associated with fibrosis and/or collagen deposition. The kit includes a vial containing an miRNA-762 inhibitor and a device for use in a surgery creating a risk of fibrosis and/or collagen deposition. The composition includes a pharmaceutical composition comprising a miRNA-762 inhibitor and a second agent selected from the group consisting of: an angiotensin-converting enzyme (ACE) inhibitors, an angiotensin receptor blocker (ARB), another antihypertensive agent, a steroid, and combinations thereof.
Vanderbilt University | Date: 2017-03-15
The invention regards the modulation of TGF- activity by administering to a subject an antibody that binds to TGF-, thereby increasing bone growth, bone formation, bone mass and bone strength. The antibody acts to increase osteoblast number and function while at the same time decreasing osteoclast number and function. Such drugs are useful in the treatment of diseases or disorders such as osteoporosis, Pagets disease, metastatic bone cancer, myeloma bone disease, bone fractures, etc.
Al Biomedical Corporation and Vanderbilt University | Date: 2017-02-15
Device and method for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.
Vanderbilt University | Date: 2017-04-12
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M_(1) (mAChR M_(1)); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Wang J.,Vanderbilt University
Nucleic acids research | Year: 2013
Functional enrichment analysis is an essential task for the interpretation of gene lists derived from large-scale genetic, transcriptomic and proteomic studies. WebGestalt (WEB-based GEne SeT AnaLysis Toolkit) has become one of the popular software tools in this field since its publication in 2005. For the last 7 years, WebGestalt data holdings have grown substantially to satisfy the requirements of users from different research areas. The current version of WebGestalt supports 8 organisms and 201 gene identifiers from various databases and different technology platforms, making it directly available to the fast growing omics community. Meanwhile, by integrating functional categories derived from centrally and publicly curated databases as well as computational analyses, WebGestalt has significantly increased the coverage of functional categories in various biological contexts including Gene Ontology, pathway, network module, gene-phenotype association, gene-disease association, gene-drug association and chromosomal location, leading to a total of 78 612 functional categories. Finally, new interactive features, such as pathway map, hierarchical network visualization and phenotype ontology visualization have been added to WebGestalt to help users better understand the enrichment results. WebGestalt can be freely accessed through http://www.webgestalt.org or http://bioinfo.vanderbilt.edu/webgestalt/.