Vanderbilt University is a private research university located in Nashville, Tennessee, United States. Founded in 1873, the university is named in honor of shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided the school its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.Today Vanderbilt enrolls approximately 12,000 students from all 50 U.S. states and over 90 foreign countries in four undergraduate and six graduate and professional schools. Several research centers and institutes are affiliated with the university, including the Vanderbilt Institute for Public Policy Studies, Freedom Forum First Amendment Center, Dyer Observatory, and Vanderbilt University Medical Center, the only Level I trauma center in Middle Tennessee. With the exception of the off-campus observatory and satellite medical clinics, all of university's facilities are situated on its 330-acre campus in the heart of Nashville, 1.5 miles from downtown. Despite its urban surroundings, the campus itself is a national arboretum and features over 300 different species of trees and shrubs. Wikipedia.
Vanderbilt University | Date: 2017-03-15
The invention regards the modulation of TGF- activity by administering to a subject an antibody that binds to TGF-, thereby increasing bone growth, bone formation, bone mass and bone strength. The antibody acts to increase osteoblast number and function while at the same time decreasing osteoclast number and function. Such drugs are useful in the treatment of diseases or disorders such as osteoporosis, Pagets disease, metastatic bone cancer, myeloma bone disease, bone fractures, etc.
Al Biomedical Corporation and Vanderbilt University | Date: 2017-02-15
Device and method for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.
Sandhill Scientific Inc. and Vanderbilt University | Date: 2017-02-06
A method of detecting and measuring the condition of intraluminal esophageal mucosa. An esophagus is intubated with a catheter including an inflatable and deflatable balloon and one or more impedance sensing electrodes on an exterior surface of the catheter. The balloon is inflated to press the impedance sensing electrode(s) into a mucosa of the interior esophageal wall. An electric current is directed through the mucosa via the impedance sensing electrode(s) while the impedance sensing electrode(s) is/are pressed by the balloon against the mucosa and measure impedance of the mucosa.
Vanderbilt University and Technion Research & Development Foundation Ltd. | Date: 2017-02-08
Disclosed herein are methods and systems that remove impurities from phosphogypsum (PG), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, PG is reacted with a chloride solution in an acidic environment under mechanical manipulation and/or heat followed by galvanic and/or zeolite absorption removal of impurities.
Vanderbilt University | Date: 2017-02-01
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Vanderbilt University | Date: 2017-04-26
A circuit includes first and second current control sub-circuits connected in series between a DC supply voltage node and a reference voltage node and third and fourth current control sub-circuits connected in series between the DC supply voltage node and the reference voltage node. The circuit also includes a DC/DC converter with a first input terminal coupled to the first load node between the first and second current control sub-circuits, a second input terminal coupled to a second load node between the third and fourth current control sub-circuits, a first output terminal, and a second output terminal. The circuit further includes output electrodes, a routing sub-circuit for selectively coupling the output electrodes to the output terminals, and a controller configured for operating the routing sub-circuit and the current control sub-circuits to cause the DC/DC converter to supply biphasic pulses for at least one of the pairs of output electrodes.
Vanderbilt University | Date: 2017-03-08
A surgical grasper includes a first handle arm, a second handle arm pivotally coupled to the first handle arm, a tool body pivotally coupled to both the first handle arm and the second handle arm, a first jaw member pivotally coupled to the tool body, a second jaw member pivotally coupled to the tool body, a first tension element coupled to both the first handle arm and to the first jaw member, a second tension element coupled to both the second handle arm and to the second jaw member, and a lock that locks relative movement between the first and second handle arms. Rotational movement of the first and second handle arms generates correlated rotational movement of the first and second jaw members.
Vanderbilt University | Date: 2017-01-19
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M_(1 )(mAChR M_(1)); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Vanderbilt University | Date: 2017-04-12
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M_(1) (mAChR M_(1)); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Wang J.,Vanderbilt University
Nucleic acids research | Year: 2013
Functional enrichment analysis is an essential task for the interpretation of gene lists derived from large-scale genetic, transcriptomic and proteomic studies. WebGestalt (WEB-based GEne SeT AnaLysis Toolkit) has become one of the popular software tools in this field since its publication in 2005. For the last 7 years, WebGestalt data holdings have grown substantially to satisfy the requirements of users from different research areas. The current version of WebGestalt supports 8 organisms and 201 gene identifiers from various databases and different technology platforms, making it directly available to the fast growing omics community. Meanwhile, by integrating functional categories derived from centrally and publicly curated databases as well as computational analyses, WebGestalt has significantly increased the coverage of functional categories in various biological contexts including Gene Ontology, pathway, network module, gene-phenotype association, gene-disease association, gene-drug association and chromosomal location, leading to a total of 78 612 functional categories. Finally, new interactive features, such as pathway map, hierarchical network visualization and phenotype ontology visualization have been added to WebGestalt to help users better understand the enrichment results. WebGestalt can be freely accessed through http://www.webgestalt.org or http://bioinfo.vanderbilt.edu/webgestalt/.