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Gurer G.,Van Research and Training Hospital | Butun B.,Akdeniz University | Tuncer T.,Akdeniz University | Unubol A.I.,Kusadasi Government Hospital
Rheumatology International | Year: 2012

This study was performed to compare radiologic methods of Bath Ankylosing Spondilitis Radiology Index-spine (BASRI-s), Bath Ankylosing Spondilitis Radiology Index-Total (BASRI-T), Stoke Ankylosing Spondilitis Spine Score (SASSS) and Modified Stoke Ankylosing Spondilitis Spine Score (M-SASSS) and to test their superiority over each other. Eighty-one patients (60 males, 21 females) with ankylosing spondylitis (AS) were included in the study. Patients were evaluated for their functional status, disease activity, quality of life, and spinal mobility using Bath AS Functional Index (BASFI), Bath AS Disease Activity Index (BASDAI), AS Quality of Life Index (ASQoL) scale, and Bath AS Metrology Index (BASMI), respectively. Radiographs of the patients were evaluated using BASRI-s, BASRI-T, SASSS, and M-SASSS methods. Spearman's correlation test was used for the correlation analysis. Significant correlations were found between the duration of disease with radiological indices (P<0.05), BASMI with SASSS (P<0.01), M-SASSS (P<0.01), BASRI-s (P<0.01), and BASRI-T (P<0.01). Furthermore, there were correlations between BASFI with SASSS (P<0.05), M-SASSS (P<0.05), BASRI-s (P<0.05). and BASRI-T (P<0.05). According to the results of our study, among these four radiological measuring methods, SASSS appears to be the one that is the least reflective of patient status. The reason to that is the fact that while in SASSS method only lumbosacral radiography is evaluated, in other methods one more area is evaluated. However, the disadvantages of BASRI methods relative to others, in BASRI methods, patients are exposed to more radiation. © Springer-Verlag 2011.

Gurer G.,Van Research and Training Hospital | Sendur F.,Adnan Menderes University | Gultekin B.K.,Adnan Menderes University | Ozcan M.E.,Fatih University
European Journal of Psychiatry | Year: 2010

Background and Objectives: This study was performed to compare the anxiety disorders between individuals with and without joint hypermobility. Methods: A total of 94 Turkish volunteers, 40 subjects (38 females, 2 males) with joint hypermobility and 54 controls (47 females, 7 males) without joint hypermobility, were included in this study. We evaluated the joint hypermobility by using the Beighton scoring system in the participants and a Beighton score of at least 4 was considered as joint hypermobility. In addition, all cases were evaluated with Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and Hamilton Anxiety Rating Scale by a psychiatrist in order to define their psychyatric disorders and anxiety levels, respectively. Results: Age, gender and educational levels of the participants were similar between these two groups. Mean of anxiety score was higher statistically in the study group (13.5 ± 5.3) than that of the control group (11.1 ± 4.9) (p < 0.05). No statistically a significant difference in the ratio of psychyatric disorders according to SCID-I were observed between cases with and without hypermobility. Conclusions: Anxiety scores have been found significantly higher in the group with hypermobility than that of the group without hypermobility. We strongly recommend the assessment of medical conditions, including joint hypermobility syndrome, in anxiety patients.

Dilek N.,Recep Tayyip Erdogan University | Ozkol H.U.,Van Research and Training Hospital | Akbas A.,Ataturk Research and Training Hospital | Kilinc F.,Ataturk Research and Training Hospital | And 4 more authors.
Postepy Dermatologii i Alergologii | Year: 2014

Introduction: According to studies conducted in outpatients, it is estimated that 2.5% of children who are treated with a drug will experience a cutaneous adverse drug reaction (CADR). Aim: To analyze the CADR reports involving pediatric patients recorded by three diferent university hospitals for describing common, serious, and interesting cutaneous drug eruption patterns. Material and methods: For this purpose, the patients' data from three diferent universities were reviewed retrospectively. Diagnosis was based on history, clinical findings and laboratory test results. The CADRs were classified into seven categories; urticaria, angioedema, maculopapular eruption, fixed drug eruption, erythema multiforme, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms syndrome. Results: A total of 122 patients who had CADRs were enrolled in the study. The most frequently detected cutaneous drug reactions were urticaria + angioedema. Most of patients had no previous experience with the same drug and the most common causative agent of CADRs was antimicrobials. Conclusions: Since CADRs are relatively rare, the current multicentric study can provide meaningful information about the cutaneous eruption patterns of commonly used drugs. © 2014, Termedia Publishing House Ltd. All rights reserved.

Erdogan S.,Adnan Menderes University | Gurer G.,Van Research and Training Hospital | Afsin H.,Adnan Menderes University | Kucukzeybek Y.,Van Research and Training Hospital
Modern Rheumatology | Year: 2011

Fibromyalgia (FM) is a chronic pain illness with unknown etiology, and it generally affects women. These patients also have gastrointestinal symptoms and signs. In this study, we aimed to evaluate the gastric emptying rate in patients with newly diagnosed FM by using the radionuclide method. Investigation of the differences in gastric emptying rate, the number of pain points, and Fibromyalgia Impact Questionnaire (FIQ) scores between premenopausal and postmenopausal FM patients was planned as secondary goal of this study. Fifteen female patients (ages 17-68 years) with FM and 15 age-matched healthy women (ages 20-65 years) as a control group participated in the study. Exponential gastric emptying rate at 30, 60, 90 min and duration of the lag phase were calculated. There was no statistically significant difference in the mean age or in the gastric emptying rates at 30, 60, and 90 min between these two groups (p>0.05). Mean time of the lag phase of the FM group was significantly longer than that of the control group (p<0.05). Average age at menopause in the FM group was also significantly lower than that of patients in the control group (p<0.05). When FM patients were divided into the two subgroups of menopausal and premenopausal patients, there was no significant difference in gastric emptying rate, duration of the lag phase, the number of pain points, and FIQ scores between these two groups (p>0.05). Although gastric emptying rate was not affected in patients with FM, grinding was prolonged. This result can be explained as one of the causes of gastrointestinal complaints of FM patients. In addition there was no determined influence of menopause on prolonged grinding. However, further studies are needed to elucidate the relationship between clinical findings and gastrointestinal functions and complaints of FM patients. © Japan College of Rheumatology 2010.

Duzen O.,Van Research and Training Hospital | Erkoc R.,Istanbul University | Begenik H.,Yuzuncu Yil University | Soyoral Y.U.,Yuzuncu Yil University | Aldemir M.N.,Yuzuncu Yil University
Renal Failure | Year: 2012

Background and objective: Prolonged corticosteroid (CS) use induces osteoporosis; the pathogenesis of this condition is multifactorial and includes CS-induced hypercalciuria. We investigated the course of hypercalciuria and related markers of bone metabolism parameters during and after the CS treatment. Materials and Methods: We recruited 42 patients who were taking at least 10 mg/day of methylprednisolone or an equivalent dose of CSs for at least 30 days. The 24-h urinary calcium and sodium, a spot urinary calcium/creatinine ratio, and urinary deoxypyridinoline were measured prior to the treatment, at day 7, at days 30-60, and after the cessation of the treatment. Additionally, the serum levels of phosphorus, calcium, alkaline phosphatase (ALP), albumin, creatinine, osteocalcin, and parathyroid hormone (PTH) were analyzed. Results: The 24-h urinary calcium excretion was significantly increased at day 7 (182.2 ± 158.6 mg/day; p < 0.001) and at days 30-60 (196.9 ± 167.8 mg/day; p < 0.001) compared with baseline (98.7 ± 88.1 mg/day) and returned to basal level after the cessation of the CSs (118.9 ± 90.2 mg/day; p = 0.725). The urinary deoxypyridinoline level was significantly higher at days 30-60 compared with basal level. The serum osteocalcin level was decreased at days 30-60 when compared with day 7. No significant changes were detected in the PTH, phosphorus, creatinine, and ALP levels. Conclusions: CS treatment induces hypercalciuria just after starting the treatment until the end of it. CS-induced hypercalciuria promptly improved after cessation of the treatment. By days 30-60, the excretion of urinary deoxypyridinoline was accompanied by hypercalciuria. The serum osteocalcin level was decreased at days 3060 when compared with day 7. © 2012 Informa Healthcare USA, Inc.

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