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Pamuk O.N.,Trakya University Medical Faculty | Kalyoncu U.,Hacettepe University | Aksu K.,Ege University | Omma A.,Ankara Numune Research and Education Hospital | And 20 more authors.
Rheumatology International | Year: 2016

In this multicenter, retrospective study, we evaluated the efficacy and safety of biologic therapies, including anti-TNFs, in secondary (AA) amyloidosis patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA). In addition, the frequency of secondary amyloidosis in RA and AS patients in a single center was estimated. Fifty-one AS (39M, 12F, mean age: 46.7) and 30 RA patients (11M, 19F, mean age: 51.7) with AA amyloidosis from 16 different centers in Turkey were included. Clinical and demographical features of patients were obtained from medical charts. A composite response index (CRI) to biologic therapy—based on creatinine level, proteinuria and disease activity—was used to evaluate the efficacy of treatment. The mean annual incidence of AA amyloidosis in RA and AS patients was 0.23 and 0.42/1000 patients/year, respectively. The point prevalence in RA and AS groups was 4.59 and 7.58/1000, respectively. In RA group with AA amyloidosis, effective response was obtained in 52.2 % of patients according to CRI. RA patients with RF positivity and more initial disease activity tended to have higher response rates to therapy (p values, 0.069 and 0.056). After biologic therapy (median 17 months), two RA patients died and two developed tuberculosis. In AS group, 45.7 % of patients fulfilled the criteria of good response according to CRI. AS patients with higher CRP levels at the time of AA diagnosis and at the beginning of anti-TNF therapy had higher response rates (p values, 0.011 and 0.017). During follow-up after anti-TNF therapy (median 38 months), one patient died and tuberculosis developed in two patients. Biologic therapy seems to be effective in at least half of RA and AS patients with AA amyloidosis. Tuberculosis was the most important safety concern. © 2016, Springer-Verlag Berlin Heidelberg. Source


Arslan D.,Erzurum Research and Education Hospital | Tural D.,Akdeniz University | Koca T.,Erzurum Research and Education Hospital | Tastekin D.,Istanbul University | And 15 more authors.
Journal of B.U.ON. | Year: 2015

Purpose: Relatively few studies have focused on T4N2 (stage HIB) locally advanced non-small cell lung cancer (NSCLC). In this study, we tried to identify prognostic factors for patients with clinical stage T4N2 NSCLC. Methods: We retrospectively identified 223 patients, of which 168 met the inclusion criteria. Patients treated with curative intent using concurrent chemoradiotherapy (CRT) with or without adjuvant chemotherapy, or concurrent CRT after induction chemotherapy, were included in this study. Relevant patient, treatment, and disease factors were evaluated for their prognostic significance in both univariate and multivariate analyses using the Cox proportional hazards model. Results: The median progression-free survival (PFS) was 13 months (95% confidence interval [CI], 10.6-15.4). The median overall survival (OS) was 20 months (95% CI, 16.8-23.1), and 71, 40.3 and 28.2% of the patients survived for 1,2 and 3 years after diagnosis, respectively. Multivariate analysis showed Eastern Cooperative Oncology Group (ECOG) performance status (PS) was independent predictor of PFS (hazard ratio [HR], 0.24; 95% CI, 0.13-0.43; p=0.001), and OS [HR, 0.48; 95% CI, 0.26-0.87; p=0.015). Absence of multifocal T4 tumors was also associated with a significantly longer OS (HR, 046; 95% CI, 0.31-0.7; p=0.001). There was no statistically significant difference in OS and PFS between treatment modalities. Conclusion: PFS and OS were significantly shorter in patients with poor ECOG PS. OS was also significantly shorter in patients with multifocal T4 tumors. There were no differences between the two therapeutic approaches with respect to outcome. Source


Belgu A.U.,Van Research and Education Hospital | Erdogan B.,Afyonkarahisar State Hospital | San T.,Istanbul Medeniyet University | Gurkan E.,Haydarpasa Research and Education Hospital
European Archives of Oto-Rhino-Laryngology | Year: 2015

This prospective study aimed to evaluate the relationship between sleep endoscopy findings, the apnea–hypopnea index (AHI) or the Epworth sleepiness scale in patients and obstructive sleep apnea syndrome (OSAS). Patients with symptoms of OSAS were searched, and their polysomnography findings, Epworth sleepiness scales and sleep endoscopy findings were recorded. Those who were diagnosed with mild, moderate or heavy OSAS were included in the study. Patients included in the study were observed under sedative-induced sleep in the operation room using flexible nasopharyngoscopy. The obstruction levels and degrees were recorded and compared with other variables. Of the 88 patients included in the study, 67 (76.1 %) were male, and 21 (23.9 %) were female. The mean age (±standard deviation) of all 88 patients was 43.77 ± 10.07 years (range 21–65 years). Sleep endoscopy findings were classified as uvulopalatal, lateral pharyngeal, tongue base and laryngeal collapses. The Epworth sleepiness scale showed no significant correlation with the sleep endoscopy findings. No significant relationship was found between the AHI and collapses in the uvulopalatal, lateral and laryngeal zones (p > 0.05). However, tongue base collapse was correlated with AHI (p < 0.05). AHI increased with the degree of collapse in the tongue base. No meaningful relationship was noted among the Epworth sleepiness scale, AHI, and number of involved zones (p > 0.05). The degree of collapse in the related zones was not meaningfully associated with AHI, which is accepted as the indicator of disease severity. © 2014, Springer-Verlag Berlin Heidelberg. Source


Guner S.,Yuzuncu Yil University | Guner S.I.,Yuzuncu Yil University | Isik Y.,Yuzuncu Yil University | Gormeli G.,Van Research and Education Hospital | And 16 more authors.
International Orthopaedics | Year: 2013

Purpose: This is a descriptive analysis, of victims of Turkey's October 23, 2011 and November 21, 2011 Van earthquakes. The goal of this study is investigated the injury profile of the both earthquakes in relation to musculoskeletal trauma. Methods: We retrospectively reviewed medical records of 3,965 patients admitted to in seven hospitals. A large share of these injuries were soft tissue injuries, followed by fractures, crush injuries, crush syndromes, nerve injuries, vascular injuries, compartment syndrome and joint dislocations. A total of 73 crush injuries were diagnosed and 31 of them were developed compartment syndrome. Results: The patients with closed undisplaced fractures were treated with casting braces. For closed unstable fractures with good skin and soft-tissue conditions, open reduction and internal fixation was performed. All patients with open fracture had an external fixator applied after adequate debridement. Thirty one of 40 patients with compartment syndrome were treated by fasciotomy. For twelve of them, amputation was necessary. The most common procedure performed was debridement, followed by open reduction and internal fixation and closed reduction-casting, respectively. Conclusions: The results of this study may provide the basis for future development of strategy to optimise attempts at rescue and plan treatment of survivors with musculoskeletal injuries after earthquakes. © 2012 Springer-Verlag Berlin Heidelberg. Source


Polat V.,Van Research and Education Hospital | Iscan S.,Van Research and Education Hospital | Etli M.,Van Research and Education Hospital | El Kilic H.,Van Research and Education Hospital | And 3 more authors.
BioMed Research International | Year: 2014

Background. Red cell distribution width (RDW) is an important marker which reflects inflammatory activity in many chronic diseases. The objective of this study is to investigate the impact of RDW on morbidity and mortality before and after pediatric congenital heart surgery. Methods. 107 patients with congenital heart disease, cardiac case group, and 70 patients, control group, without heart disease were retrospectively analyzed. Pre-, and postoperative and at discharge RDW of the cardiac patients were determined. Lengths of hospital and intensive care unit (ICU) stay and exited patients were determined. Results. Mean lengths of ICU and hospital stay were 3.3±2.7 and 7.3±2.9 days. In control group, mean preoperative RDW was 12.6±1.4, while in cardiac case group it was significantly higher (15.1±3.5). In cardiac case group, postoperative RDW were significantly higher than preoperative period, while RDW at discharge were significantly lower than postoperative estimates. A significant and a positive correlation was detected between lengths of ICU and hospital stay and RDW. RDW of the exited patients were significantly higher than the survivors. Conclusions. This study demonstrates that RDW can be used as an important indicator in the prediction of morbidity and mortality during pre-, and postoperative period of the pediatric congenital heart disease surgery. © 2014 Vural Polat et al. Source

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