Toluca de Lerdo, Mexico
Toluca de Lerdo, Mexico

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PubMed | University Anahuac, National Autonomous University of Mexico, University of Chile, Austral University of Chile and 2 more.
Type: Journal Article | Journal: The journal of the American College of Clinical Wound Specialists | Year: 2017

The incidence of ulcers associated to type 2 diabetes mellitus (T2DM) increases every year. We introduce and explore a new mathematical algorithm to evaluate wound-healing in foot ulcers associated to T2DM. Fifteen patients (nine women and six men), mean age of 7016 years were included. The evolution of their wounds followed-up for a period of 18-45 days. According to the Wagner grading system the ulcers were grade I (5 patients), grade II (9 patients), and grade III (1 patient). Clinically, the type of the ulcers was neuroischemic (12 patients) and neuropathic (3 patients). A new parameter is introduced, the continuous linear healing rate Dc that was more accurate with higher values and requires less quantifications than usual formulas to make a wound-healing projection.


Tenorio-Borroto E.,Valle de Toluca University | Ramirez F.R.,Valle de Toluca University | Speck-Planche A.,University of Porto | Cordeiro M.N.D.S.,University of Porto | And 4 more authors.
Current Drug Metabolism | Year: 2014

The immune system helps to halt the infections caused by pathogenic microbial and parasitic agents. The ChEMBL database lists very large datasets of cytotoxicity of organic compounds but notably, a large number of compounds have unknown effects over molecular and cellular targets in the immune system. Flow Cytometry Analysis (FCA) is a very important technique to determine the effect of organic compounds over these molecular and cellular targets in the immune system. In addition, multi-target Quantitative Structure-Property Relationship (mt-QSPR) models can predict drug-target interactions, networks. The objectives of this paper are the following. Firstly, we carried out a review of general aspects and some examples of applications of FCA to study the effect of drugs over different cellular targets. However, we focused more on methods, materials, and experimental results obtained in previous works reported by our group in the study of the drug Dermofural. We also reviewed different mt-QSPR models useful to predict the immunotoxicity and/or the effects of drugs over immune system targets including immune cell lineages or proteins. Secondly,we included new results not published before. Initially, we used ChEMBL data to train and validate a new model but with emphasis in the effect of drugs over lymphocytes. Lastly, we report unpublished results of the computational and FCA study of a new nitro-vinyl-furan compound over thymic lymphocytes T helpers (CD4+) and T cytotoxic (CD8+) population. © 2014 Bentham Science Publishers.


Orozco R.S.,Instituto Tecnologico Of Estudios Superiores Of Jocotitlan | Orozco R.S.,University of Zaragoza | Hernandez P.B.,National Autonomous University of Mexico | Morales G.R.,National Autonomous University of Mexico | And 6 more authors.
BioResources | Year: 2014

To use a new potential lignocellulosic bioresource that has several attractive agroenergy features for ethanol production, the chemical characterization and compositional analysis of several fruit wastes were carried out. Orange bagasse and orange, banana, and mango peels were studied to determine their general biomass characteristics and to provide detailed analysis of their chemical structures. Semiquantitative analysis showed that the components for each fruit waste differed with respect to chemical composition. Fourier transform infrared spectrometry (FTIR) of the residual biomass showed the presence of various functional groups-aldehydes or ketones (C=O), alkanes (C-C), and ethers (C-O-C). Even water molecules were detected, indicating the complex nature of the feedstocks. The concentrations of total sugars ranged between 0.487 g.g-1 and 0.591 g.g-1 of dry weight biomass. The thermal profiles (TG-DSC) of the residual fruits occurred in at least three steps, which are associated with the main components (hemicellulose, cellulose, and lignin). The decomposition by thermal analysis was completed at around 600 °C and was influenced by the nature of the component ratio.


Belyaeva T.L.,National Autonomous University of Mexico | Perez-Torres R.,Valle de Toluca University | Ogloblin A.A.,RAS Research Center Kurchatov Institute | Demyanova A.S.,RAS Research Center Kurchatov Institute | And 2 more authors.
Physical Review C - Nuclear Physics | Year: 2014

An analysis of the differential cross sections of the C12(d,p)C13 (ground state, or g.s., 1/21+) and Be10(d,p)Be11 (g.s., 1/21-) reactions at the incident deuteron energies of 11.8, 25.9, and 30 MeV for the first system, and 12.0 and 25.0 MeV for the second system has been performed by applying the coupled-reaction-channels method. The spectroscopic factors Sexpt, asymptotic normalization coefficients (ANCs), and rms radii of the last neutron in the ground states and the first excited states of the stable C13 and the radioactive Be11 nuclei were extracted. The existence of neutron halos in the first excited state of C13 and the ground state of Be11 is confirmed. The rms radii of halos in these states were found to be 5.72±0.16 and 8.0±0.2 fm, respectively, in agreement with experimental results. We showed that a halo is also formed in the 0.32 MeV 1/21- excited state of Be11. The halo radius in this state was determined for the first time and was found to be Rh=4.65±0.20 fm. © 2014 American Physical Society.


Belyaeva T.L.,National Autonomous University of Mexico | Danilov A.N.,RAS Research Center Kurchatov Institute | Demyanova A.S.,RAS Research Center Kurchatov Institute | Goncharov S.A.,Skobeltsyn Institute of Nuclear Physics | And 2 more authors.
Physical Review C - Nuclear Physics | Year: 2010

Evidence of the 3α-particle condensate character of the Hoyle state (the 02+ state at 7.65 MeV in C12) implies not only an enhanced radius of C12 in this state, which was established by many theoretical calculations and confirmed by the recent diffraction model analysis, but also zero relative angular momenta between clusters. We performed coupled-channels model calculations of the angular distributions of α+12C elastic and inelastic (to the 4.44-MeV 2⊃+, 7.65-MeV 02+, and 9.65-MeV 31- states) scattering at 110 MeV and found the ratio of the empirical spectroscopic factors S(L). As the differential cross sections of these reactions are characterized by pronounced enhancement and strong oscillations at large angles, we assumed a potential scattering in the forward hemisphere and the direct transfer of a Be8 cluster at θc.m. 90⊃° and took into account the direct transfer of Be8 in the ground state and in the first excited 2⊃+ and 4⊃+ states. We found that the cluster configuration with L=0 dominates in the 02+ state, being more than three times larger than that in the ground state. This result provides additional evidence of the condensed structure of the Hoyle state in C12 with a dominance of zero relative angular momentum. The negative-parity 31- excited state in C12 observed above the 3α threshold is also considered to have the 3α-cluster structure. The present calculations described well the structure of the large-angle cross section on this state. We found a positive interference for all allowed α+8Be configurations with a dominance of the p-orbital (69%)α+8Be motion and confirmed the exotic, but hardly a condensed, structure of this state. © 2010 The American Physical Society.


Velazquez-Pena S.,National Autonomous University of Mexico | Linares-Hernandez I.,National Autonomous University of Mexico | Martinez-Miranda V.,National Autonomous University of Mexico | Barrera-Diaz C.,Autonomous University of Mexico State | And 2 more authors.
Separation Science and Technology (Philadelphia) | Year: 2013

The goal of this work was to evaluate the effectiveness of iron and boron-doped-diamond (BDD) as cathodic electrodes on the reduction of Cr(VI) in synthetic and wastewater samples. The pH and electrolyte composition were varied, and the effect on the Cr(VI) reduction rate was measured. The optimized conditions from the synthetic water Cr(VI) reduction experimental data, were tasted on electroplating wastewater. The results indicated that both a pH of 2 and the use of NaCl as an electrolyte significantly increase the Cr(VI) reduction rate for all synthetic systems, especially the iron-BDD system. The Cr(VI) reduction rate in Fe-BDD systems was also affected by nitrate and sulfate ions. In the case of electroplating wastewater, Cr(VI) reduction by BDD cathodes was faster than with iron cathodes, achieving a complete reduction of 180 mg Cr(VI)/L in 25 min, with 40% less sludge produced. The elemental composition of sludge was analyzed using SEM/EDS and X-ray spectroscopy to confirm that iron and chromium precipitated out of the solution. The sludge had a chemical composition of (31.9%) Fe2O3, (29.6%) FeOOH, (21%) FeO, and (17.4%) FeSO4. Therefore, BDD as an electrode material effectively reduces Cr(VI) in electroplating wastewater, and can be effectively scaled up to industrial applications. © 2013 Copyright Taylor and Francis Group, LLC.


Barrera-Diaz C.E.,Autonomous University of Mexico State | Lugo-Lugo V.,Autonomous University of Mexico State | Lugo-Lugo V.,Valle de Toluca University | Bilyeu B.,Xavier University of Louisiana
Journal of Hazardous Materials | Year: 2012

Hexavalent chromium is of particular environmental concern due to its toxicity and mobility and is challenging to remove from industrial wastewater. It is a strong oxidizing agent that is carcinogenic and mutagenic and diffuses quickly through soil and aquatic environments. It does not form insoluble compounds in aqueous solutions, so separation by precipitation is not feasible. While Cr(VI) oxyanions are very mobile and toxic in the environment, Cr(III) cations are not. Like many metal cations, Cr(III) forms insoluble precipitates. Thus, reducing Cr(VI) to Cr(III) simplifies its removal from effluent and also reduces its toxicity and mobility. In this review, we describe the environmental implications of Cr(VI) presence in aqueous solutions, the chemical species that could be present and then we describe the technologies available to efficiently reduce hexavalent chromium. © 2012 Elsevier B.V.


Lugo-Lugo V.,Valle de Toluca University | Lugo-Lugo V.,Autonomous University of Mexico State | Barrera-Diaz C.,Autonomous University of Mexico State | Urena-Nunez F.,Instituto Nacional de Investigaciones Nucleares | And 2 more authors.
Journal of Environmental Management | Year: 2012

Trivalent chromium and iron are the products of the traditional reduction of hexavalent chromium by ferrous salts in industrial wastewater. Although there have been a few studies of Cr(III) adsorption, none have considered the effect of Fe(III) on Cr(III) adsorption in a binary system representing expected products of hexavalent chromium in industrial wastewater. The biosorption of Cr(III) and Fe(III) ions onto pretreated ground orange peel in single and binary systems was studied in batch experiments using a variety of techniques. The kinetic results showed a rapid rate of biosorption of Cr(III) and Fe(III) in single and binary systems and mutual interference effects in the competitive binary Cr(III)-Fe(III) system. Second order kinetic models showed the best fit for all systems. The behavior of competitive Cr(III)-Fe(III) biosorption were successfully described by the multicomponent Langmuir model, obtaining maximum capacities for Cr(III) and Fe(III) of 9.43 and 18.19 mg/g respectively. SEM/EDS results confirmed that the metals adsorb on the surface and FTIR identified the hydroxyl groups on the carboxylic acids as the active binding sites. © 2012 Elsevier Ltd.


PubMed | Valle de Toluca University, National Autonomous University of Mexico and Autonomous University of Mexico State
Type: Journal Article | Journal: Environmental technology | Year: 2016

The aim of this work was to implement a coupled system, a monopolar Electrocoagulation (EC)-Electrooxidation (EO) processes, for the treatment of soft drink wastewater. For the EC test, Cu-Cu, anode-cathode were used at current densities of 17, 51 and 68mAcm


Almazan-Sanchez P.T.,National Autonomous University of Mexico | Linares-Hernandez I.,National Autonomous University of Mexico | Martinez-Miranda V.,National Autonomous University of Mexico | Lugo-Lugo V.,Valle de Toluca University | Guadalupe Fonseca-Montes De Oca R.M.,National Autonomous University of Mexico
Catalysis Today | Year: 2014

Oxidation-adsorption treatments were applied to improve the biodegradability of wastewater from the manufacture of acrylic resins with methyl methacrylate (MMA). MMA wastewater has an extremely complex composition, with a chemical oxygen demand (COD) concentration of 651.25-g O2/L, total organic carbon (TOC) concentration of 227.86 g/L, N-NH3 concentration of 48.80 g/L, and 352,500-PtCo units. In this study, the effects of operating parameters that include the Fenton reagent dosage, the initial pH, and the reaction time of the treatment efficiencies of the Fenton oxidation process were observed. The improvement in the biodegradability was attributed to the removal of ammonium and organic pollutants from the wastewater, which was confirmed using infrared spectroscopy. After this process, adsorption of organic matter from wastewater was also studied; kinetic and equilibrium adsorption studies were performed to evaluate the effect of the contact time and pH. Pseudo-second-order kinetics represented the experimental data well, and Langmuir and Freundlich isotherm models were tested to represent the data. The maximum adsorption capacity obtained was qm = 1.15 g/g for TOC and 11.65 g/g for COD at optimum conditions. The removal efficiencies of the Fenton adsorption treatment were 96% of color, 58% of TOC, and 60% COD. © 2013 Elsevier B.V. All rights reserved.

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