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Kazemi A.,Vali r University of Rafsanjan
Scientific Journal of Kurdistan University of Medical Sciences | Year: 2015

Background and Aim: Abnormality in motor proteins involved in axonal transport is one of the common signs of neurodegenerative disease. KIF1B is one of these motor proteins. Although there are several reports related to impairment of this protein and its gene expression in the central nervous system diseases, it is not clear whether decreased activity in the form of spinal nerve ligation changes KIF1B gene expression in the peripheral nervous system. Hence, the aim of this study was to investigate the effect of decreased activity and neuropathic pain on KIF1B gene expression in sciatic nerve fiber of male Wistar rats. Materials and methods: Ten adult male Wistar rats weighting 250±30 gr were randomly divided into two groups, control (C), and decreased physical activity (SNL). Neuropathic pain behavioral tests were performed in both groups for six weeks. After sixth weeks, KIF1B gene expression in sciatic nerve was measured using real time technique. Results: Behavioral tests demonstrated that spinal nerve ligation induces thermal hyperalgesia and mechanical allodynia in the SNL group. This decreased pain threshold was seen in all stages of the study (P<0.05). Also, compared with the C group, KIF1B gene expression in sciatic nerve fiber was significantly lower in SNL group (P<0.05). Conclusion: Decreased activity in the form of SNL could be associated with neurodegerative signs such as hyperalgesia, allodynia, and decreased KIF1B gene expression. Given the physiological role of KIF1B in neurons, this condition may cause functional disorders in the neuromuscular systems. © 2015, Kurdistan University of Medical Sciences. All rights reserved. Source

Hosseini Ezzabadi J.,Iran University of Science and Technology | Dehghani Saryazdi M.,Vali r University of Rafsanjan | Mostafaeipour A.,University of Yazd
Applied Soft Computing Journal | Year: 2015

In the current volatile and demanding business environment, managers are so eager to demonstrate that their organizations are excellent which can mainly be achieved through continuous performance improvement. The most applicable and suitable tools that by the assessment of organizations shows how successful they are in the organizational excellence path is European Foundation for Quality Management (EFQM) Excellence Model. This study aims at presenting a new integrated approach based on EFQM model using Fuzzy Logic, Analytical Hierarchy Process (AHP) technique and Operations Research (OR) model to improve the organizations' excellence level by increasing the quality of business performance evaluation and determining of improvement projects with high priority. A case study in Yazd Regional Electricity Co. in Iran is presented to demonstrate the applicability of the proposed approach. In a way that, primarily, performance assessment by crisp method and the proposed method, Fuzzy method, is carried out. Then, strength points and the areas for improvement are identified by defining the scores for sub-criteria. Next, sub-criteria are prioritized to define the improvement projects by using AHP technique and Operations Research model. Finally, improvement projects with high priority are determined and some action plans for improvement projects are defined. © 2015 Elsevier B.V. All rights reserved. Source

Ayni S.,University of Kashan | Sabet M.,Vali r University of Rafsanjan | Salavati-Niasari M.,University of Kashan
Journal of Cluster Science | Year: 2016

In this study, lead molybdate (PbMoO4) nanostructures were synthesized successfully via a simple and fast co-precipitation method. A new lead precursor [pb(2-hydroxyacetophenone)]2 was used for synthesis of the product. It was seen that using lead complex led to create of very tiny structures that can be attributed its steric effect. Different parameters such as pH, surfactant kind and solvent were changed to study their effect on the product size and morphology. It was found each parameter can effect on the product shape and change particle size and morphology. Different analysis such as scanning electron microscopy, X-ray diffraction pattern, Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy were used to characterize the fabricated products. Also photocatalytic activity of the product was studied by UV–Visble spectroscopy and it was found that synthesized lead molybdate can act as photocatalyst under visible light range. © 2015, Springer Science+Business Media New York. Source

Ghoohestani M.,Malek-Ashtar University of Technology | Karimipour M.,Vali r University of Rafsanjan | Javdani Z.,Shahid Chamran University
Physica Scripta | Year: 2014

The structural, optical and electronic properties of the copper nitride (Cu3N) bulk structure under pressure have been studied by performing accurate total energy calculations in the framework of density functional theory using the full-potential linearized augmented plane wave method. Perdew-Burke-Ernzerhof and modified Becke-Johnson parameterizations of the generalized gradient approximation were employed to obtain the structural and electronic properties of Cu3N. The most stable crystal structure of the Cu3N compound was found to be cubic anti-ReO3 at ambient pressure. Moreover, the calculation of the enthalpy of different crystal structures of Cu3N for different pressures indicates that the anti-ReO3 cubic phase undergoes a structural phase transition for pressures higher than 30 GPa. The study of the elastic constants of the anti-ReO3 cubic phase confirms that Cu3N is mechanically stable under hydrostatic pressures up to 30 GPa. Moreover, with the application of pressure, the C44 elastic constant, shear module and Debye temperature deviate from linear behavior at 10 GPa. An electronic study shows that there is an electronic-type phase transition from semiconductor to metal between 5 and 10 GPa and metal to semi-metal between 20 and 30 GPa applied pressures. Cu3N is an indirect band gap semiconductor with a value of 0.56 eV. © 2014 The Royal Swedish Academy of Sciences. Source

Ghoohestani M.,Vali r University of Rafsanjan | Karimipour M.,Vali r University of Rafsanjan | Badehian H.A.,Shahid Chamran University | Hashemifar S.J.,Isfahan University of Technology
Journal of Magnetism and Magnetic Materials | Year: 2013

We have studied intercalation of nitrogen atom into the cubic Cu 3N structure by performing accurate total energy calculations in the framework of density functional theory by using the full-potential linearized augmented plane wave method. The spin polarized Perdew-Burke-Ernzerh of (PBE) and modified Becke-Johnson (mBJ) parameterizations of the generalized gradient approximation were employed to obtain the structural and electronic properties of Cu3N and Cu3N2 structures. It is found that nitrogen intercalation into Cu3N is an endothermic process which significantly influences the structural, electronic, and magnetic properties of the system. This process, within PBE, gives rise to a nearly half metallic behavior, while mBJ favors semiconductor ferromagnetism in the intercalated Cu3N2 system. The 2p orbital of the intercalated nitrogen atom shows significant contribution to the spin polarization of the system. © 2013 Elsevier B.V. All rights reserved. Source

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