Brasili E.,University of Rome La Sapienza |
Filho V.C.,Vale do Itajai University
Critical Reviews in Food Science and Nutrition | Year: 2017
Cancer is a multi-factorial disease and is a major cause of morbidity and mortality worldwide. Dietary phytochemicals have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Several studies have been performed to elucidate the effects of dietary phytochemicals on cancer metabolism, and many molecular targets of phytochemicals have been discovered. In spite of remarkable progress, their effects on cancer metabolism have not yet been fully clarified. Recent developments in metabolomics allowed to probe much further the metabolism of cancer, highlighting altered metabolic pathways and offering a new powerful tool to investigate cancer disease. In this review, we discuss the main metabolic alterations of cancer cells and the potentiality of phytochemicals as promising modulators of cancer metabolism. We will focus on the application of nuclear magnetic resonance-based metabolomics on breast and hepatocellular cancer cell lines to evaluate the impact of curcumin and resveratrol on cancer metabolome with the aim to demonstrate the premise of this approach to provide useful information for a better understanding of impact of diet components on cancer disease. © 2017 Taylor & Francis Group, LLC.
Niero R.,Vale do Itajai University |
de Andrade S.F.,Vale do Itajai University |
Filho V.C.,Vale do Itajai University
Current Pharmaceutical Design | Year: 2011
Plants belonging to the genus Maytenus (Celastraceae) are routinely used in folk medicine in Brazil and other countries to treat a variety of illnesses, the most common of which are gastric disorders. Several studies have reported on the importance of these biological effects, and the chemical substances, mostly terpenoids and flavonoid glycosides, responsible for them. This review summarizes the ethnopharmacological, chemical and pharmacological knowledge of plants of the Maytenus genus, with particular emphasis on those growing in Brazil. © 2011 Bentham Science Publishers.
Moreira J.,Vale do Itajai University |
Klein-Junior L.C.,Vale do Itajai University |
Filho V.C.,Vale do Itajai University |
Buzzi F.D.C.,Vale do Itajai University
Journal of Ethnopharmacology | Year: 2013
Ethnopharmacological relevance: Corilagin (β-1-O-galloyl-3,6-(R)- hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries. Aim of the study: This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice. Materials and methods: Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice. Results: Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09-13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15-22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3 mg/kg. Conclusion: The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system. © 2013 Elsevier Ireland Ltd. All rights reserved.
Meyre-Silva C.,Vale do Itajai University |
Cechinel-Filho V.,Vale do Itajai University
Current Pharmaceutical Design | Year: 2010
The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors. © 2010 Bentham Science Publishers Ltd.
Vale do Itajai University and Eurofarma Laboratorios Sa | Date: 2013-02-28
The present invention refers to a process for obtaining a standardized extract having antinociceptive, anti-inflammatory and antipyretic properties, from at least one part of a plant of genus Aleurites. Furthermore, the present invention provides a pharmaceutical composition comprising an active ingredient of a pharmaceutically efficient quantity of standardized extract from at least one part of the plant of genus Aleurites. Finally, the present invention describes a method of treatment and use of the said extract, isolated or in a pharmaceutical composition, for the prevention, control or treatment of painful, inflammatory or febrile affections.
Vertical transmission of HIV, syphilis and hepatitis B in the municipality with the highest incidence of AIDS in Brazil: A population-based study from 2002 to 2007 [Transmissão vertical do HIV, da sífilis e da hepatite B no município de maior incidência de AIDS no Brasil: Um estudo populacional no período de 2002 a 2007]
Kupek E.,Federal University of Santa Catarina |
de Oliveira J.F.,Vale do Itajai University
Revista Brasileira de Epidemiologia | Year: 2012
Objective: The objective of this study was to verify the prevalence and vertical transmission rate of HIV, syphilis and hepatitis B in pregnant women in the municipality of Itajaí, state of Santa Catarina, Brazil, during the 2002-2007 period. Methods: Data were collected in a retrospective population-based longitudinal study using computerized medical records of the state and local health authorities during the 2002-2007 period for HIV, and 2004-2007 for syphilis and hepatitis B. Results: The prevalence of HIV, acute hepatitis B, chronic hepatitis B and syphilis in pregnant women was 1.7%, 0.41%, 0.46%, and 0.43%, respectively. Overall, vertical transmission of HIV was 6.28%, although it was less than 5% among women diagnosed with HIV before or during pregnancy, compared to 20% and 55% among women first diagnosed with HIV during and after delivery, respectively. Vertical transmission of syphilis was 68.89%. No trend was confirmed for the transmission rate either regarding the year of diagnosis or age group of pregnant women. Almost 44% of HIV infected pregnant women knew their HIV status before becoming pregnant; the HIV transmission rate for these women was less than 5%. No case of vertical transmission was observed for hepatitis B. Conclusions: The vertical transmission rate for HIV was within the target of the Ministry of Health when HIV diagnosis was made during pregnancy, but increased sharply when the diagnosis was made only at delivery. Vertical transmission of syphilis was much higher than expected, showing the importance of reinforcing the procedures recommended for its reduction.
Resgalla C.,Vale do Itajai University
Ecotoxicology | Year: 2016
Since the 1960s, little has been done to improve and simulate the use of short-duration chronic bioassays of bivalve embryos, particularly in mussels. However, these test organisms offer great advantages in relation to other groups, due to the ease of obtaining breeders in cultivation systems, in the environment and any time, and due to their high sensitivity to chemicals or contaminants. To contribute some methodological aspects, this study uses techniques to stimulate spawning or improve the obtaining of gametes for use in bioassays with the mussel Mytilus galloprovincialis. It also evaluates different criteria for determining the effect on the larvae, for estimation of EC50 and NOEC values, based on morphological analysis of developmental delay and the biometrics of the larvae. KCl proved to be a reliable inducer of spawning, with positive responses in 10 of the 12 months of the year tested. Moreover, this chemical, in association with NH4Cl, demonstrated the capacity to activate immature oocytes obtained from extirpated gonads, enabling an improvement in fertilization rates. The different criteria adopted to determine the effects on the larvae in the assays with reference toxicants (SDS and K2Cr2O7) resulted in EC50 and NOEC values without significant differences, indicating reliability in the results and freedom in the choice of criteria of effect to be adopted in the trials. © 2016 Springer Science+Business Media New York
Benitti F.B.V.,Vale do Itajai University
Computers and Education | Year: 2012
This study reviews recently published scientific literature on the use of robotics in schools, in order to: (a) identify the potential contribution of the incorporation of robotics as educational tool in schools, (b) present a synthesis of the available empirical evidence on the educational effectiveness of robotics as an educational tool in schools, and (c) define future research perspectives concerning educational robotics. After systematically searching online bibliographic databases, ten relevant articles were located and included in the study. For each article, we analyze the purpose of the study, the content to be taught with the aid of robotics, the type of robot used, the research method used, and the sample characteristics (sample size, age range of students and/or level of education) and the results observed. The articles reviewed suggest that educational robotics usually acts as an element that enhances learning, however, this is not always the case, as there are studies that have reported situations in which there was no improvement in learning. The outcomes of the literature review are discussed in terms of their implications for future research, and can provide useful guidance for educators, practitioners and researchers in the area. © 2011 Published by Elsevier Ltd. All rights reserved.
Schwarz R.,Vale do Itajai University |
Perez J.A.A.,Vale do Itajai University
Fisheries Research | Year: 2010
Statoliths of 689 Illex argentinus specimens collected by national and foreign trawlers in Brazilian waters were analyzed. Catches occurred between 2001 and 2008, from 23° to 32° S and at depths of 80-730. m. Exponential, Power, Gompertz and Schnute models were fitted to size-at-age data and the logistic model was used for maturity modeling. Fitting procedures used the maximum log-likelihood and Akaike criteria for identification of best models. Total age estimates ranged between 56 and 320 days for squid between 35 and 376. mm mantle lengths. Gompertz and Schnute models, which suggest the positive acceleration of growth in the early stages of ontogeny followed by a decrease in the second phase, provided the best fit to the size-at-age dispersion in this study. The inflection point in the maturity curve was 137 days for males and 143 days for females. The age range for post-spawning squid was 116-250 (average 187) days for males and 133-280 (average 201) days for females showing a life cycle close to six months. None of the examined individuals reached one year of age. The wide range of sizes-at-age implied that catches of I. argentinus off southern Brazil probably include mixed micro-cohorts and different population units. © 2010 Elsevier B.V.
Rossetto A.L.,Vale do Itajai University |
Cruz R.C.B.,Vale do Itajai University
Anais Brasileiros de Dermatologia | Year: 2012
The authors report a case (in Itajai, Santa Catarina State, Brazil) of tinea nigra in a 4-year-old female child which spontaneously healed. We discuss the clinical and epidemiological aspects of the mycosis and this rare case of spontaneous healing. © 2012 by Anais Brasileiros de Dermatologia.