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İstanbul, Turkey

Ozaras N.,Vakif Gureba Training Hospital | Rezvani A.,Vakif Gureba Training Hospital
Indian Journal of Pharmacology | Year: 2010

Background: Osteoporosis is caused by bone resorption in excess of bone formation, and bisphosphonates, are used to inhibit bone resorption. Alendronate, a biphosphonate, is effective for both the treatment and prevention of osteoporosis in postmenopausal women. Side effects are relatively few and prominently gastrointestinal. Musculoskeletal pain may be an important side effect in these patients. We presented a patient admitted to our out-patient clinic with diffuse skeletal pain after three consecutive administration of alendronate. Conclusion: We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis. Source


Eryilmaz R.,Akdeniz University | Bilecik T.,Antalya Training and Research Hospital | Okan I.,Vakif Gureba Training Hospital | Ozkan O.V.,Vakif Gureba Training Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

Squamous cell carcinoma (SCC) is a rare complication observed mainly in chronic, recurrent and untreated primary pilonidal disease. It is associated with poor prognosis, and its recurrence rate after surgery is high. Here we present a patient diagnosed with SCC arising from a neglected pilonidal sinus. A 44-year-old male, who is a heavy truck driver, applied to the hospital with chronic discharge from sacrococcygeal region. He had symptoms of the disease with multiple recurrent abscesses and spontaneous drainage for 10 years. The patient underwent cyst excision and the defect was left open for secondary healing. One year later, the patient was admitted to the hospital with a mass of 3 x 3 cm in the same area. Re-excision and a sigmoid colostomy were performed. The patient died after two years. This case study illustrates that since SCC is a fatal complication of recurrent and long-standing pilonidal sinus, the proper treatment of this disease should be carried out as soon as the diagnosis is established. To this end, we believe, that all pilonidal sinus lesions should be sent for pathologic examination. Source


Kucukali C.I.,Istanbul Erenkoy Psychiatric and Neurological Disorders Hospital | Aydin M.,Istanbul University | Ozkok E.,Istanbul University | Bilge E.,Istanbul University | And 3 more authors.
Psychiatric Genetics | Year: 2010

Background: Family, twin and adoption studies have provided major evidence for the role of genetics in numerous psychiatric disorders including schizophrenia (SZ) and bipolar disorders (BDs). As SZ and BD have some susceptibility genes in common and since unaffected first-degree relatives of these patients carry a high likelihood of these susceptibility genes, we aimed to elucidate the role of angiotensin-converting enzyme (ACE) genetic variants in patients with SZ, BD and their first-degree relatives. Methods: The study sample comprised 239 patients with SZ, 184 patients with BD, 284 unaffected first-degree biological relatives of patients with SZ and 301 unaffected first-degree biological relatives of patients with BD and 210 healthy controls. The ACE genotypes were determined by polymerase chain reaction. Results: ACE insertion/deletion polymorphism was associated with SZ and BD. DD genotype and D allele distributions in bipolar patients and their first-degree relatives were significantly higher than those of SZ patients, their relatives, and controls. In contrast, II genotype and I allele were reduced in both the patient groups and their relatives as compared with controls. Conclusion: In this study, the D allele might be responsible for clustering of psychotic symptoms and results in the psychotic manifestations of BD, whereas I allele seems to be protective against development of SZ and BD. SZ and BD characterized by similar or different gene variant in ACE could be a useful marker for these psychiatric disorders, if this polymorphism is replicated in the future studies. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source


Esenyel C.Z.,Vakif Gureba Training Hospital | Ozturk K.,Vakif Gureba Training Hospital | Demirhan M.,Istanbul University | Sonmez M.,Sisli Etfal Training Hospital | And 4 more authors.
Archives of Orthopaedic and Trauma Surgery | Year: 2010

Purpose: Intra-articular glenohumeral injections have an important role for therapeutic benefit and diagnostic information. Therefore, it is very important that the injected material should reach its desired target. This study assessed the accuracy of an anterior intra-articular injection in fresh cadavers. Methods: A total of 50 shoulders of 25 fresh cadavers were included in the study. Anterior placement of a spinal needle using a location just 1 cm lateral to the coracoid, without radiographic assistance were performed. After the needle was placed and estimated to be intra-articular 1 cc of acrylic dye was injected into the joint to determine accuracy of position. Results: Ninety-six percent of injections were accurately administered into the glenohumeral joint and 4% in the surrounding soft tissues and capsule. Conclusion: Based on our cadaveric study, an unassisted anterior injection to the glenohumeral joint could be accurately placed. © 2009 Springer-Verlag. Source


Kural Y.B.,Vakif Gureba Training Hospital | Su O.,Vakif Gureba Training Hospital | Onsun N.,Vakif Gureba Training Hospital | Uras A.R.,Vakif Gureba Training Hospital
International Journal of Dermatology | Year: 2010

Background: Even though several case studies have reported a relationship between Cutaneous T Cell Lymphoma (CTCL) and atopic diathesis, this association is still controversial. The aim of this study was to investigate the actual presence of atopic status in CTCL patients. Methods: A total of 78 patients with both clinical and histological features typical of CTCL and 77 control cases from our outpatient dermatology clinic were included in this study. After initial evaluation and staging, all patients were investigated for history of atopic disease, serum total IgE and eosinophil cationic protein concentration (ECP), eosinophil count, serum specific IgE, and skin prick test positivity. Results: Personal atopy in CTCL group was 23,1% (n = 18) and familial atopy was 9.0% (n = 7) whereas in the control group, these values were 11.7% (n = 9) and 7.8% (n = 6), respectively. There was no statistically significant difference, however, the number of atopic patients were higher in CTCL group than the control group (p = 0.151). Serum total IgE levels were significantly increased in patients with CTCL when compared to control group (p = 0.04). Serum specific IgE panel and prick test positivity between patients and controls were significantly different, respectively (p = 0. 03) (p = 0. 00). Eosinophil counts and ECP levels were not significantly different, respectively (p = 0.10) (p = 0.885). In high stages of CTCL, patients were found to have elevated IgE, ECP levels and eosinophil count. These results were statistically significant (p = 0.011) (p = 0.009) (p = 0.007). Conclusion: Eventhough the number of patients with atopy in the CTCL group was higher than the control cases, there was no significant different. On the other hand high levels of serum IgE, elevated eosinophil count and specific IgE positivity may be found in CTCL patients with or without atopic disease, especially with high stages. © 2010 The International Society of Dermatology. Source

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