Vagner Perm State Medical Academy

Perm’, Russia

Vagner Perm State Medical Academy

Perm’, Russia
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Trushnikova T.N.,Vagner Perm State Medical Academy | Medvedeva E.L.,Vagner Perm State Medical Academy | Baidina T.V.,Vagner Perm State Medical Academy | Danilova M.A.,Vagner Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objective. To study serum concentrations of BDNF and CNTF in patients with multiple sclerosis (MS) and compare them to clinical characteristics of MS. Material and methods. We examined 43 patients with confirmed diagnosis of MS according to McDonald’s criteria with remitting type of disease course. Patients were in a stable condition and did not receive hormone treatment during the last 30 days. Serum concentrations of BDNF and CNTF were measured using ELISA. Results. Mean serum BDNF concentration was 7.9 (5.21; 14.7) ng/ml that was significantly lower (p=0.0001) compared to control values and was correlated with depression severity (r= –0.31, p=0.04) and physical asthenia (r= –0.32, p=0.04). CNTF concentration was 69.9 (31.2; 123.3) pg/ml (CNTF was not found in healthy people) and was correlated with the results of cognitive function assessment (the PASAT test) (r= –0.30, p=0.046). Conclusion. The difference in BDNF and CNTF serum concentrations between MS patients and healthy people and correlations with some clinical characteristics of MS provide evidence for the involvement of these factors in MS pathogenesis. © 2014, Media Sphera. All rights reserved.


Trushnikova T.N.,Vagner Perm State Medical Academy | Baidina T.V.,Vagner Perm State Medical Academy | Danchenko I.Y.,Vagner Perm State Medical Academy | Kuklina E.M.,Russian Academy of Sciences | Nekrasova I.V.,Russian Academy of Sciences
Neuroscience and Behavioral Physiology | Year: 2015

The expression of semaphorin CD100 by intact peripheral blood T lymphocytes from patients with multiple sclerosis (MS) not receiving immunomodulatory treatment was studied. Cellular CD100 expression levels were assessed, along with levels of CD72 receptor-carrying B lymphocytes. Significant differences were seen between the levels of CD100 expression in patients with MS and healthy donors. These data suggest the possibility of using semaphorin as a potential target for actions on MS-associated pathological inflammatory processes. © 2015, Springer Science+Business Media New York.


Kulesh A.A.,Vagner Perm State Medical Academy | Shestakov V.V.,Vagner Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objective. To study melatonin secretion and its correlations with poststroke cognitive, emotional impairment and sleep quality in the acute period of stroke and to assess treatment efficacy of melaxen. Material and methods. We studied 96 patients with acute stroke. A battery of tests and scales for assessment of neurological deficit, neuropsychological status and emotional impairment was used. The night urinary level of 6-sulfatoxymelatonin was assessed. The relationship between 6-sulfatoxymelatonin and cognitive, emotional status and sleep parameters was analyzed. Results. The level of 6-sulfatoxymelatonin was decreased in the night urine. Patients with dysexecutive poststroke cognitive impairment had higher level of 6-sulfatoxymelatonin and patients with dysmnestic and mixed cognitive impairment had lower level of 6-sulfatoxymelatonin in comparison with patients with normal cognitive functions. Melaxen improved cognitive function and sleep parameters, reduced the level of anxiety in the early recovery period of stroke. Conclusion. A role of chronobiological processes in the development of clinical signs of stroke in the aspect of cognitive impairment is discussed.


Kulesh A.A.,Vagner Perm State Medical Academy | Lapaeva T.V.,Vagner Perm State Medical Academy | Shestakov V.V.,Vagner Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objective: To study chronobiological characteristics of ischemic stroke (II) and post stroke cognitive impairment (CI). Material and methods: We examined 80 patients with acute ischemic stroke. The cognitive status, sleep quality, chronobiological parameters and night urinary level of 6-sulfatoxymelatonin were assessed. The clinical observation of the efficacy of melaxen treatment in intensive care unit was performed. Results: The results of the study indicate the significance of social and environmental factors which determine the sleep-wake behavior in the development of pineal dysfunction. The pineal dysfunction probably underlies the development of stroke and accompanied neurodegenerative process. Conclusion: The use of melaxen in hyperacute stroke was associated with better recovery of circadian rhythms and rehabilitation results. © 2014, Media Sphera. All rights reserved.


Baev V.M.,Vagner Perm State Medical Academy
Patologicheskaia fiziologiia i èksperimental'naia terapiia | Year: 2013

The parameters of blood rheology at constant and varying shear rates in 30 patients with community-acquired pneumonia on a background of hypertension and 30 patients with community-acquired pneumonia during treatment. When recovery of rheological properties of blood disorders are in 39-81% of patients.


Malov A.G.,Vagner Perm State Medical Academy | Ovchinnikova E.S.,Vagner Perm State Medical Academy | Vlasova I.Y.,Vagner Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

This article describes clinical cases of 13 year old boy with two non-convulsive status epilepticus which had transient epileptic amnesia as a clinical implication. Status EEG pattern in form of diffuse epileptic activity «benign epileptiform discharge of childhood» type was registered.


Kravtsov Y.I.,Vagner Perm State Medical Academy | Shevchenko K.V.,Vagner Perm State Medical Academy | Kravtsova E.Y.,Vagner Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective. To study the dynamics of plasma concentration of stress hormones (ACTH and cortisol) and lactate as well as the integrative stress level indicator at neuroreanimation stage of severe cranial-brain injury. Material and methods. Authors examined 34 patients with traumatic intracranial hematomas including 19 patients who died during the first two weeks after admission to the hospital and 15 patients who were discharged for outpatient treatment. To assess stress level, we used the indicator of stress level estimated as body mass x 1/3 x heart rate frequency x pulse pressure x 0,000126. Contents of blood plasma ACTH and cortisol were determined using radioimmune method, lactic acid was measured with enzyme colorimetric method. A control group included the indicators of 10 healthy people aged from 24 to 44 years. Results and conclusion. In the first 24 h, the overstrain of the neuroendocrine system in response to strong stress influence of the trauma was noted in all patients. In patients with fatal outcome, an increase in cortisol in the first 24 h was excessive and lactate level was significantly higher during the observational period compared to the patients with favorable outcome. The peak of mortality was at 1—5 days when the stress level indicators, contents of ACTH, cortisol and lactate reached maximal values indicating the stress-induces overstrain of the hypothalamic- pituitary-adrenal axis and promoting the development of brain tissue hypoxia. © 2015, Media Sphera. All rights reserved.


Baev V.M.,Vagner Perm State Medical Academy | Koryukina I.P.,Vagner Perm State Medical Academy | Kudryavtseva E.N.,Vagner Perm State Medical Academy | Koltyrina E.N.,Vagner Perm State Medical Academy | Kozlov D.B.,Vagner Perm State Medical Academy
World Journal of Medical Sciences | Year: 2013

The study objective was to identify the specific characteristics of the mental status in the young women with low BP and assess its possible association with ANS disbalance. Out of 1264 young women (age: 17-35), the study group of 69 persons with low SBP (61-99 mm Hg) and the control group of 35 persons with normal SBP (120-129 mm Hg) were formed. SBP and DBP as well as heart rate were measured; Kerdo index was calculated. We used Eysenck Personality Questionnaire (EPQ) and Zung Self-Rating Depression Scale. For statistical analysis, the Spearman's rank correlation coefficient, Mann-Whitney U-test and chi-square test were used. The young women with low or normal BP showed no difference in the levels of anxiety, frustration, aggressiveness, rigidity, or depression states. The young women with low BP demonstrated AMS disbalance with sympathetic predominance. However, no correlation between Kerdo index and the mental status or depression level was revealed in hypotension. © IDOSI Publications, 2013.


Gein V.L.,Perm State Pharmaceutical Academy | Kazantseva M.I.,Perm State Pharmaceutical Academy | Gein L.F.,Vagner Perm State Medical Academy | Slepukhin P.A.,Russian Academy of Sciences
Russian Journal of Organic Chemistry | Year: 2014

Reactions of alkyl acetoacetates, aromatic aldehydes, ammonium acetate, and 1,3-cyclohexanedione afford alkyl 4-aryl-2-methyl-5-oxo-1,4,5,6,7,8- hexahydroquinoline-3-carboxylates. The structure of compounds obtained was established with the help of IR, 1H NMR, and mass spectra and by X-ray diffraction analysis. © 2014 Pleiades Publishing, Ltd.


PubMed | Vagner Perm State Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2015

To study the dynamics of plasma concentration of stress hormones (ACTH and cortisol) and lactate as well as the integrative stress level indicator at neuroreanimation stage of severe cranial-brain injury.Authors examined 34 patients with traumatic intracranial hematomas including 19 patients who died during the first two weeks after admission to the hospital and 15 patients who were discharged for outpatient treatment. To assess stress level, we used the indicator of stress level estimated as body mass x 1/3 x heart rate frequency x pulse pressure x 0,000126. Contents of blood plasma ACTH and cortisol were determined using radioimmune method, lactic acid was measured with enzyme colorimetric method. A control group included the indicators of 10 healthy people aged from 24 to 44 years.In the first 24 h, the overstrain of the neuroendocrine system in response to strong stress influence of the trauma was noted in all patients. In patients with fatal outcome, an increase in cortisol in the first 24 h was excessive and lactate level was significantly higher during the observational period compared to the patients with favorable outcome. The peak of mortality was at 1-5 days when the stress level indicators, contents of ACTH, cortisol and lactate reached maximal values indicating the stress-induces overstrain of the hypothalamic- pituitary-adrenal axis and promoting the development of brain tissue hypoxia.

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