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Wellesley, MA, United States

Patent
Vaccine Technologies Incorporated | Date: 2010-06-11

Described are compositions and methods for detecting or monitoring the ability of an individual to mount a cell mediated immune response to a target antigen. Methods rely in part upon the physical association, e.g., by fusion, of a Lethal Factor (LF) polypeptide with a target antigen. The LF polypeptide moiety, including, for example, an LFn polypeptide moiety, serves as a transport factor to deliver target antigens, including full length target polypeptides, to the cytosol of an intact, living immune cell from an individual. Measurement of a cytokine response by the immune cell from the individual provides a read out of a cell cell from mediated immune response. The methods and compositions described provide diagnostic as well as prognostic information and can guide the direction of therapy.


Patent
Vaccine Technologies Incorporated | Date: 2010-06-11

The present invention is directed to a method for promoting or stimulating a cell-mediated immune response to an antigen, by administering a target antigen (such as a protein) with a transport factor that contains a fragment of a bipartite protein exotoxin, but not the corresponding protective antigen. Preferred transport factors include the protective antigen binding domain of lethal factor (LFn) from


Patent
Vaccine Technologies Incorporated | Date: 2011-06-09

The present invention generally relates to HIV compositions and methods of use. One aspect of the present invention relates to a composition comprising a pharmaceutically acceptable carrier and an antigen preparation, the antigen preparation comprising an HIV polypeptide or fragment thereof and a


Trademark
Vaccine Technologies Inc. | Date: 2008-02-11

Vaccine adjuvants; Vaccine stabilizers; Vaccines.


Trademark
Vaccine Technologies Inc. | Date: 2008-02-11

Diagnostic agents, preparations and substances for medical purposes; diagnostic assay preparations for medical use. Medical services; assay services in the medical field, namely, disease and infection diagnosis, profiling, and prognosis.

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