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Artigues-près-Bordeaux, France

Doussau A.,University Pierre and Marie Curie | Doussau A.,French Institute of Health and Medical Research | Doussau A.,University Hospital | Doussau A.,Bordeaux University | And 18 more authors.
Annals of Oncology

In phase I trials, severe and moderate toxicities occurring after the first cycle of treatment are important sources of information. Model-based approach can be used to evaluate per cycle probability of moderate or severe toxicity and cumulative probability of severe toxicity over time. It increases precision of estimates, and it enables investigating increased probability of toxicity over time. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. Source

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