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Thatikonda S.,Vaageswari Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2013

An attempt has been made to develop and evaluate Orally Disintegrating or Mouth Dissolving tablets of Metoclopromide for quick effect, better patient compliance and effective therapy. Fast dissolving tablets of Metoclopromide were prepared by direct compression technique using selected superdisintegrants. The FTIR spectra revealed that, there was no interaction of drug with formulation ingredients. The prepared tablets were evaluated for drug content, friability, hardness, In vitro disintegration and In vitro release studies. All the tablets with different super disintegrants showed better results. However, required disintegration and dissolution behavior of Metoclopromide was achieved for tablets with Crospovidone (20%) as super disintegrant. Source

Mondal P.,P.A. College | Santhosh S.B.,P.A. College | Satla S.R.,Jawaharlal Nehru Technological University | Raparla R.,Vaageswari Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2013

A reversed phase HPLC method has been developed for the simultaneous determination of Escitalopram oxalate and Etizolam by using C18 (250 × 4.6 mm) column and mobile phase of 0.02M Potassium dihydrogen orthophosphate: Acetonitrile (40:60) at 254 nm. Retention times of Escitalopram oxalate and Etizolam were 2.8 min and 4.1 min respectively with resolution of 6.52. This method shows to be linear (r2>0.99), precise (RSD<2%), accurate (recovery of 99.8% of Escitalopram oxalate and 99.46% of Etizolam), specific and robust. The Escitalopram oxalate contains in tablets was 99.8 % where Etizolam contains was 99.33%. Source

A novel, sensitive, and rapid UV spectrophotometric and colorimetric method was developed for estimation of etizolam (ETZ) in bulk and tablet. The UV spectrophotometric method (method I) is based on quantitative estimation of ETZ using 0.1N NaOH as the solvent which exhibits maximal absorption at 378 nm. Colorimetric methods (method II and III) were based on the formation of color complex in association with ions between basic nitrogen of the drug with methyl orange (MO) and bromocresol green (BCG) in acidic medium. The formed color complexes were quantitatively extracted with chloroform and measured at 509 nm for Drug–MO complex and at 442 nm for Drug–BCG complex, respectively. Beer’s law was obeyed over the linear ranges 2–16 µg/ml (method I), 5–45 µg/ml (method II), and 2–20 µg/ml (method III). The correlation coefficient (r2) for ETZ was 0.999, 0.997, and 0.998 for method I, II, and III, respectively. All methods were successfully applied for the assay of the drug in tablet. The % purity was found to be 98.52 (method I), 98.72 (method II), and 99.18 (method III). These developed methods were fully validated with % relative standard deviation (RSD) for accuracy less than 2 for all methods. The % RSD of the intra-day and inter-day variations was found to be less than 2%. The limit of detection and quantitation were as follows: 0.108 µg/ml and 0.327 µg/ml (method I), 0.24 µg/ml and 0.75 µg/ml (method II), 0.1 µg/ml and 0.5 µg/ml (method III) indicating marked method sensitivity. Empirical evidence from all three methods concludes that developed methods are simple, sensitive, and reliably validated for useful routine quality control analysis of ETZ. © 2015 Taylor & Francis. Source

Thatikonda S.,Vaageswari Institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The purpose of this research was to design a reservoir type transdermal system for delivering selegiline using a hydrogel-based drug reservoir and a rate-controlling membrane, prepared by solvent casting method by using 2 % w/V of Eudragit RS100 and 0.10% w/V of polyvinyl pyrrolidone K30 (PVP K30) was added in the formulation as pore creating agent. The preparations were evaluated for thickness, drug content, weight variation, tensile strength, folding Endurance. All prepared formulations indicated good physical stability. The in-vitro diffusion studies were carried out using modified Keshery-Chein cell with cellophane as diffusion membrane and the formulations followed Higuchi diffusion mechanism. The formulations containing HEC as polymer showed faster release rate compared to HPMC K4M and the release profile of selegiline followed Higuchi model kinetics in different formulations. However, the release profile of the optimized formulation R4 (r2 = 0.9992 for Higuchi) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation R4 showed highest flux among all the formulations. Source

Dholi S.K.,Vaageswari Institute of Pharmaceutical science | Raparla R.,Vaageswari Institute of Pharmaceutical science | Mankala S.K.,Vaageswari Institute of Pharmaceutical science | Nagappan K.,Annamalai University
Journal of Applied Pharmaceutical Science | Year: 2011

Azadirachta indica has been used medicinally throughout history by many different cultures. Many compounds have been found in the exudates of the, Azadirachta indica plant that have been used medically by humans. We have examined the pharmacological hypoglycemic action of Azadirachta indica in diabetic rats. After treatment for 24 hrs, Azadirachta indica 250mg/kg (single dose study) reduced glucose (18%), cholesterol (15%), triglycerides (32%), urea (13%), creatinine (23%), and lipids (15%). Multiple dose study for 15days also reduced creatinine, urea, lipids, triglycerides and glucose. In a glucose tolerance test in diabetic rats with neem extract 250 mg/kg demonstrated glucose levels were significantly less compared to the control group. , Azadirachta indica significantly reduce glucose levels at 15th day in diabetic rats. Azadirachta indica serves as an important alternative source in the management of diabetes mellitus involved in reducing increased blood glucose during diabetes which should be examined further by oral hypoglycemic therapy. Source

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