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A series of novel bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes (5a-e and 6a-e) has been synthesized and characterized by IR, 1H and 13C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d, 5e, 6b, 6c and 6e exhibited potent activity against the tested bacteria and fungi, and emerged as potential molecules for further development. Source

Srinivas A.,Vaagdevi Degree and PG College | Sunitha M.,Vaagdevi Degree and PG College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Synthesis of a series of 1,4-substitued triazoles has been accomplished starting from piperonyl alcohols prepared by the addition reaction of piperonal with Grignard reagent. Key features of the synthesis include ZrCl4 catalyzed nucleophilic substitution on piperonyl alcohol by TMSN3 and subsequent copper catalyzed click reaction with alkyne to form 1,4-disubstitued triazoles. The significant antimicrobial activity of synthesized azides and 1,4-substituted triazole derivatives has also been evaluated. Characterization of all the compounds has been carried out by IR, 1H NMR, MS and elemental analysis. Source

Avula S.,Vaagdevi Degree and PG College | Malladi S.,Vaagdevi Degree and PG College | Gaddam R.K.,Vaagdevi Degree and PG College
Organic Communications

The stereoselective synthesis of the (C1-C24) fragment of Antanapeptin-A is described. The required stereochemistry of β-hydroxy-α-methyl acid unit was accomplished through Aldol reaction using Evans' chiral auxiliary followed by the installation of terminal alkyne with Ohira-Bestmann reagent. © 2016 ACG Publications. Source

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