North Texas VA Healthcare System

Dallas, TX, United States

North Texas VA Healthcare System

Dallas, TX, United States

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Wang X.,University of Texas Southwestern Medical Center | Dong Y.,University of Texas Southwestern Medical Center | Jiwani A.J.,University of Texas Southwestern Medical Center | Jiwani A.J.,North Texas VA Healthcare System | And 8 more authors.
Proteome Science | Year: 2011

An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states is presented. The signals are amplified linearly by a confocal laser Quantum dot scanner resulting in ~1000-fold more sensitivity than traditional Western blots, but are not linear by the enzyme-based amplification. Software is developed to facilitate the quantitative readouts of signaling network activities. Kinetics of EGFRvIII mutant signaling was analyzed to quantify cross-talks between EGFR and other signaling pathways. © 2011 Wang et al; licensee BioMed Central Ltd.

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