Roberts C.K.,University of California at Los Angeles |
Croymans D.M.,University of California at Los Angeles |
Aziz N.,University of California at Los Angeles |
Butch A.W.,University of California at Los Angeles |
Lee C.C.,VA Greater Los Angeles Healthcare System GRECC
Metabolism: Clinical and Experimental | Year: 2013
Objective Evidence suggests that SHBG affects glycemic control, predicts both T2D and metabolic syndrome, and is low in obese subjects. We sought to determine if resistance exercise training (RT) can increase sex hormone-binding globulin (SHBG) and ameliorate levels of related steroid hormones in overweight/obese, sedentary young men. Materials/Methods 36 participants (BMI 31.4 kg/m2, age 22 years) were randomized into an RT (12 weeks of training, 3/week) or control group (C, 12 weeks no training), and assessed for changes in SHBG, cortisol, testosterone, free testosterone (FT) and free androgen index (FAI). In addition, body composition and oral glucose tolerance testing was performed. Results 12 weeks of RT increased SHBG (P = 0.01) and decreased FAI (P < 0.05) and cortisol (P < 0.05) compared to C. FT decreased in RT (P = 0.01). Total testosterone did not change in either group. These changes were noted without weight loss, and in concert with increases in lean body mass (P = 0.0002 vs C) and decreases in glucose area under the curve (AUC) (P = 0.004), insulin AUC (P = 0.03), and total (P = 0.002) and trunk (P = 0.003) fat mass in RT. Conclusion In overweight/obese young men, RT increases SHBG and lowers FAI in obese young adult men. © 2013 Elsevier Inc.
Supiano M.A.,University of Utah |
Supiano M.A.,VA Salt Lake City Geriatric Research |
Alessi C.,University of California at Los Angeles |
Alessi C.,VA Greater Los Angeles Healthcare System GRECC |
And 7 more authors.
Journal of the American Geriatrics Society | Year: 2012
Department of Veterans Affairs (VA) Geriatric Research, Education and Clinical Centers (GRECCs) originated in 1975 in response to the rapidly aging veteran population. Since its inception, the GRECC program has made major contributions to the advancement of aging research, geriatric training, and clinical care within and outside the VA. GRECCs were created to conduct translational research to enhance the clinical care of future aging generations. GRECC training programs also provide leadership in educating healthcare providers about the special needs of older persons. GRECC programs are also instrumental in establishing robust clinical geriatric and aging research programs at their affiliated university schools of medicine. This report identifies how the GRECC program has successfully adapted to changes that have occurred in VA since 1994, when the program's influence on U.S. geriatrics was last reported, focusing on its effect on advancing clinical geriatrics in the last 10 years. This evidence supports the conclusion that, after more than 30 years, the GRECC program remains a vibrant "jewel in the crown of the VA" and is poised to make contributions to aging research and clinical geriatrics well into the future. © 2012, The American Geriatrics Society.