1 VA Boston Healthcare System 12 A

Boston, United Kingdom

1 VA Boston Healthcare System 12 A

Boston, United Kingdom

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PubMed | Spaulding Rehabilitation Hospital, 1 VA Boston Healthcare System 12 A, Massachusetts General Hospital, Biomedical Imaging Center and Harvard University
Type: Journal Article | Journal: Photomedicine and laser surgery | Year: 2016

We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI. LED therapy is nonthermal, painless, and noninvasive. An LED-based device classified as nonsignificant risk (FDA cleared) was used. Each LED cluster head (5.35cm diameter, 500mW, 22.2mW/cm

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