Uttrakhand Technical University

Dehradun, India

Uttrakhand Technical University

Dehradun, India
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Kumar S.,Uttrakhand Technical University | Kumar N.,P.A. College | Drabu S.,Maharaja Surajmal Institute of Pharmacy
Oriental Journal of Chemistry | Year: 2017

Thirteen new compounds belonging to series 2-amino-6-(5,10-dioxo-2,3-diphenyl-5,10-dihydrobenzo[g]quinoxalin-7-yl)-4-(substituted)phenylpyridine-3-carbonitrile (6a-m) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their antimycobacterial activity by L.J. Slope (Conventional) Method. Compound 6h with 4-N(CH3)2 group at phenyl ring of above mentioned position has been reported as most active antimycobacterial compound and compound 6k with 4-CH3 substitution at phenyl above mentioned position has been reported as the least active antimycobacterial compound. © 2017, Oriental Scientific Publishing Company. All rights reserved.


Ahmad Y.,Uttrakhand Technical University | Chaudhary M.,A And G Pharmaceutical, Inc.
Pharmacologyonline | Year: 2012

Background: Quinazolinone is a compound made up of two fused six member simple aromatic rings-benezene and pyrimidine ring and have been reported to posses versatile type of biological activities such as anticancer, anticonvulsant, anti-inflammatory, antihelminthic, antimicrobial activities. Methods: A series of novel substituted-[1,2,4]triazolo[1,5c]quinazolinone derivatives (K11-19) were synthesized by mannich reaction using formamide and different secondary amines. Structures of compounds synthesized were confirmed by FT-IR, 1H-NMR and Mass spectroscopic analysis. All synthesized compounds were screened for anti-inflammatory activity. The anti-inflammatory activity was performed at concentration (100 mg/kg body mass) by rat paw oedema model. Diclofenac sodium (50 mg/kg) was used as standard. Results: All synthesized compounds have shown anti-inflammatory activity as all has significant reduction in inflammation when compared to inflammatory control group. Compounds K 15, K 18 and K 19 have shown very good anti-inflammatory activity comparable to standard drug Diclofenac sodium.


Tripathi R.P.,Graphic Era University | Mishra S.M.,Uttrakhand Technical University
Journal of Applied Probability and Statistics | Year: 2014

The purpose of this study is to investigate the impact of permissible delay in the inventory system. In a recent paper, Teng et al (2011) established an inventory model of optimal ordering policy for stock-dependent demand under progressive payment scheme. Motivated by Teng et al (2011) this paper develops an inventory model for deteriorating items have inventory-level dependent demand rate under trade credits. The deterioration is taken as constant. Mathematical models are derived under two different cases i.e. case I: The permissible delay period is less than or equal to the cycle time for settling the account and case II: The permissible delay period is greater than the cycle time for settling the account. Numerical examples are given to validate the proposed model. Sensitivity analyses with the variations of different parameters are provided to illustrate the proposed model. © ISOSS Publications 2014.


Chaudhary M.,A And G Pharmaceutical, Inc. | Ahmad Y.,Uttrakhand Technical University
Der Pharmacia Lettre | Year: 2012

Quinazolinone is a compound made up of two fused six member simple aromatic rings-benezene and pyrimidine ring and have been reported to posses versatile type of biological activities such as anticancer, anticonvulsant, antiinflammatory, antihelminthic, antimicrobial activities. A series of novel substituted- [1,2,4]triazolo[1,5c]quinazolinone derivatives (K11-19) were synthesized by mannich reaction using formamide and different secondary amines. Structures of compounds synthesized were confirmed by IR, 1H-NMR and Mass spectroscopic analysis. All synthesized compounds were screened for anti-tubercular activity. The anti-tubercular activity of synthesized compounds was performed against M. tuberculosis H37Rv at concentration 30 μg/ml using Streptomycin and Pyrazinamide 7.5 μg/ml as standard drug. All synthesized compounds have shown anti-tubercular activity as compared to standard drug Streptomycin, Pyrazinamide. Compounds K 13 and K 17 have shown very good anti-tubercular activity.


Katyal T.,Uttrakhand Technical University | Budhiraja R.D.,Uttrakhand Technical University
Der Pharmacia Lettre | Year: 2013

The present study has been designed to investigate the combined effect of daidzein (caveolin inhibitor) and hemin (hemoxygenase activator) in diabetic nephropathy in wistar rats. Diabetes mellitus in rat was induced by feeding of high-fat diet (HFD) for 2 weeks, followed by single dose of streptozotocin (STZ) (35 mg/kg, i.p.) further followed by HFD for further 8 weeks. DN was clinically assessed by estimation of various biochemical parameters and histopathological studies of renal tissue. DN was assessed by measuring serum creatinine, renal cortical collagen content, serum nitrite/nitrate ratio, renal TBARS, reduced glutathione levels. The combination of daidzein and hemin showed significant improvement in ( serum creatinine, kidney weight/ body weight, renal cortical collagen content, nitrite/ nitrate level, renal TBARS, reduced glutathione) renal parameters studied for DN in comparison with single drug administration. L-NAME (NG-nitro-L-arginine methyl ester) a selective eNOS inhibitor abolished the ameliorative effect of combination of daidzein and hemin in DN in rats. It may be concluded that Daidzein in combination with hemin may enhance the level of renal nitric oxide by decreasing the expression of caveolin. . Treatment with daidzein with hemin was more effective as compared to individual drugs. These finding provide mechanistic insights to explain renoprotective effect of this combined therapy in diabetes.


Sharma A.,Uttrakhand Technical University | Sharma M.K.,Amrapali Institute | Dwivedi R.K.,Teerthanker Mahaveer University
Proceedings of the 5th International Conference on System Modeling and Advancement in Research Trends, SMART 2016 | Year: 2017

Prime intends of web mining is to mine valuable information and knowledge from web. Social network analysis has become a very well-liked field of research as it is functional for many applications. In this study we will examine the existing soft computing techniques in the area of web mining. We develop efficient methods and algorithms using soft computing approaches. Our Framework will base on Hybrid soft computing Model. Validation is verified only by numerical simulations and MATLAB simulations. © 2016 IEEE.


Goel A.,University of the Humanities | Goel A.,Uttrakhand Technical University | Taj G.,University of the Humanities | Pandey D.,University of the Humanities | And 2 more authors.
Genomics, Proteomics and Bioinformatics | Year: 2011

The mechanism of calcium uptake, translocation and accumulation in Poaceae has not yet been fully understood. To address this issue, we conducted genome-wide comparative in silico analysis of the calcium (Ca 2+) transporter gene family of two crop species, rice and sorghum. Gene annotation, identification of upstream cis-acting elements, phylogenetic tree construction and syntenic mapping of the gene family were performed using several bioinformatics tools. A total of 31 Ca 2+ transporters, distributed on 9 out of 12 chromosomes, were predicted from rice genome, while 28 Ca 2+ transporters predicted from sorghum are distributed on all the chromosomes except chromosome 10 (Chr 10). Interestingly, most of the genes on Chr 1 and Chr 3 show an inverse syntenic relationship between rice and sorghum. Multiple sequence alignment and motif analysis of these transporter proteins revealed high conservation between the two species. Phylogenetic tree could very well identify the subclasses of channels, ATPases and exchangers among the gene family. The in silico cis-regulatory element analysis suggested diverse functions associated with light, stress and hormone responsiveness as well as endosperm- and meristem-specific gene expression. Further experiments are warranted to validate the in silico analysis of the predicted transporter gene family and elucidate the functions of Ca 2+ transporters in various biological processes. © 2011 Beijing Genomics Institute.


Bishnoi L.C.,Uttrakhand Technical University | Jat D.S.,University of Namibia
Advances in Intelligent Systems and Computing | Year: 2016

This paper proposes a Novel Cross-layer Mechanism (NCLM) for Improving H.264/AVC Video Transmissions over IEEE 802.11n wireless network. According to the network traffic loads and the importance of the video data, the proposed mechanism dynamically selects the suitable access categories (AC) instead of predefined AC. This proposed novel cross-layer mechanism gives the information about the importance of video packets to the MAC layer. Information about the network traffic load is available from the queue length of all access categories. During this research, we analyzed the performance of NCLM in both light and heavy load over IEEE 802.11n wireless networks. In this research, the performance of video traffic measured by average: Throughput, PSNR, VQM, and SSIM. Simulation results of this research demonstrate that the performance of proposed mechanism was higher in comparison to the results derived from IEEE 802.11n EDCA, CLOT, DACMM, IPB-Frame AMM, and Static Mapping algorithm. © Springer Science+Business Media Singapore 2016.


Goel A.,Govind Ballabh Pant University of Agriculture & Technology | Goel A.,Uttrakhand Technical University | Gaur V.S.,Govind Ballabh Pant University of Agriculture & Technology | Arora S.,Govind Ballabh Pant University of Agriculture & Technology | And 2 more authors.
OMICS A Journal of Integrative Biology | Year: 2012

The calcium (Ca2+) transporters, like Ca2+ channels, Ca2+ ATPases, and Ca2+ exchangers, are instrumental for signaling and transport. However, the mechanism by which they orchestrate the accumulation of Ca2+ in grain filling has not yet been investigated. Hence the present study was designed to identify the potential calcium transporter genes that may be responsible for the spatial accumulation of calcium during grain filling. In silico expression analyses were performed to identify Ca2+ transporters that predominantly express during the different developmental stages of Oryza sativa. A total of 13 unique calcium transporters (7 from massively parallel signature sequencing [MPSS] data analysis, and 9 from microarray analysis) were identified. Analysis of variance (ANOVA) revealed differential expression of the transporters across tissues, and principal component analysis (PCA) exhibited their seed-specific distinctive expression profile. Interestingly, Ca2+ exchanger genes are highly expressed in the initial stages, whereas some Ca2+ ATPase genes are highly expressed throughout seed development. Furthermore, analysis of the cis-elements located in the promoter region of the subset of 13 genes suggested that Dof proteins play essential roles in regulating the expression of Ca 2+ transporter genes during rice seed development. Based on these results, we developed a hypothetical model explaining the transport and tissue specific distribution of calcium in developing cereal seeds. The model may be extrapolated to understand the mechanism behind the exceptionally high level of calcium accumulation seen in grains like finger millet. © 2012 Mary Ann Liebert, Inc.


Gupta S.K.,Uttrakhand Technical University | Govil K.,Uttrakhand Technical University | Agarwal A.,JP Institute of Engineering and Technology
Proceedings - 2015 International Conference on Computational Intelligence and Communication Networks, CICN 2015 | Year: 2015

A Mobile Ad hoc Network (MANET) is a wireless network that supports the mobile nodes to communicate with each other without using fixed infrastructure. There are many issues with MANET such as security, power consumption, storage, processing power. For Life of network is directly proportional battery power in mobile nodes. The present research paper presents an algorithm that reduces the power consumption by using binary conversion technique in addressing mode. Mobile node looses their battery power at different rate at different mode such as data transmission mode, reception mode, idle mode, power sever mode. The given algorithm maintains the mobile node in lower power consumption stage. © 2015 IEEE.

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