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Danner U.N.,Altrecht Eating Disorders Rintveld | Danner U.N.,Utrecht Research Group Eating Disorders | Dingemans A.E.,Center for Eating Disorders Ursula | Steinglass J.,Columbia University
Current Opinion in Psychiatry | Year: 2015

Purpose of review This review compares the literature on cognitive remediation therapy (CRT) for eating disorders with findings in the field of schizophrenia, and discusses future directions for CRT for eating disorders. Recent findings First studies using a randomized controlled trial design show the added value of CRT for eating disorders. Patients reported lessened symptoms and further improvements in quality of life and cognitive flexibility. Furthermore, the acceptability of the intervention was good and attrition rates for CRT itself were low. Research into the use of cognitive remediation for schizophrenia is extensive and the results on global cognition appeared to be robust at post-treatment and durable at follow-up, with small to medium effect sizes. Recent articles within the field of schizophrenia emphasize the necessity of intrinsic motivation to translate cognitive gains into actual changes in everyday life. Summary A next step is to examine the impact of CRT for eating disorders on motivation. It is also important to focus on the transdiagnostic use of CRT, considering the overlap in cognitive inefficiencies between eating disorders. Another important step may be to develop effective personalized methods of CRT by taking into account individual differences in cognitive processes most relevant to improvement in outcome. © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Cardona Cano S.,Utrecht Research Group Eating Disorders | Cardona Cano S.,Parnassia Bavo Psychiatric Institute | Cardona Cano S.,Altrecht Mental Health Institute | Merkestein M.,University Utrecht | And 5 more authors.
CNS Drugs | Year: 2012

Ghrelin is the only known circulating orexigenic hormone. It increases food intake by interacting with hypothalamic and brainstem circuits involved in energy balance, as well as reward-related brain areas. A heightened gut-brain ghrelin axis is an emerging feature of certain eating disorders such as anorexia nervosa and Prader-Willi syndrome. In common obesity, ghrelin levels are lowered, whereas post-meal ghrelin levels remain higher than in lean individuals. Agents that interfere with ghrelin signalling have therapeutic potential for eating disorders, including obesity. However, most of these drugs are only in the preclinical phase of development. Data obtained so far suggest that ghrelin agonists may have potential in the treatment of anorexia nervosa, while ghrelin antagonists seem promising for other eating disorders such as obesity and Prader-Willi syndrome. However, large clinical trials are needed to evaluate the efficacy and safety of these drugs. © 2012 Adis Data Information BV. All rights reserved. Source

Van Elburg A.A.,Altrecht Mental Health Institute | Van Elburg A.A.,Utrecht Research Group Eating Disorders | Hillebrand J.J.G.,Altrecht Mental Health Institute | Hillebrand J.J.G.,Utrecht Research Group Eating Disorders | And 12 more authors.
International Journal of Eating Disorders | Year: 2012

Objective: A comparison of the efficacy of a novel treatment method for anorexia nervosa (AN), the Mandometer treatment (MT), with treatment as usual (TAU). Method: During treatment data were collected to determine weight recovery and outcome as assessed by the Morgan Russell Outcome Assessment Schedule (MROAS). Results: After treatment 63% of the MT group and 85% of the TAU group had reached a normal weight level and both MT and TAU showed a good outcome on the MROAS (75 and 71%, respectively). After two years more MT than TAU patients were still in treatment and more MT patients had relapsed. Discussion: The outcome for both treatments in our study were similar and comparable with, if not better than outcome data of other AN studies. MT is not superior to TAU in outcome results and in relapse rate during the first two years following admission for AN treatment. © 2011 by Wiley Periodicals, Inc. Source

Danner U.N.,Altrecht Eating Disorders Rintveld | Danner U.N.,Utrecht Research Group Eating Disorders | Sternheim L.,Altrecht Eating Disorders Rintveld | Sternheim L.,Utrecht Research Group Eating Disorders | And 2 more authors.
Psychiatry Research | Year: 2014

People with eating disorders (ED) have difficulties regulating their emotions adaptively. Little is known about differences and similarities between different types of ED and how these regulation difficulties relate to other emotional problems. The present study examines maladaptive (suppression) and adaptive (cognitive reappraisal) emotion regulation strategies in women with different ED and relationships with anxiety and depression levels. In 32 women with AN restrictive subtype (ANR), 32 with AN binge-purge subtype (ANBP), 30 with bulimia nervosa (BN), 29 with binge eating disorder (BED), and 64 healthy women, the ERQ (emotion regulation) as well as STAI-T (anxiety), BDI-SF (depression), and EDDS (eating pathology) were administered. Women across different ED subtypes were inclined to suppress emotions and lacked the capacity to reappraise emotions (except women with ANBP). Correlational relations of suppression and reappraisal with anxiety and depression levels differed across ED groups. Emotion regulation problems were found across ED subtypes. However, the types of emotion regulation problems, and the effect of coexisting other emotional problems such as anxiety and depression may differ across ED subtypes. These findings illustrate the importance to of considering ED subtypes in emotion regulation research rather than consider ED as a whole. © 2014 Elsevier Ireland Ltd. Source

Danner U.N.,Altrecht Mental Health Institute | Danner U.N.,Utrecht Research Group Eating Disorders | Sanders N.,Altrecht Mental Health Institute | Sanders N.,University Utrecht | And 16 more authors.
International Journal of Eating Disorders | Year: 2012

Objective: The purpose of this study is to examine set-shifting, central coherence, and decision making in women currently ill with anorexia nervosa (AN), women recovered from AN, and healthy control women. We aim to test whether these neuropsychological weaknesses persist after recovery, and explore relations between the impairments Results: Compared to control women, ill and recovered women showed poor set-shifting and decision making. There were strong correlations between set-shifting and central coherence in the ill and recovered women. Decision making did not correlate with the other measures. Discussion: The present findings suggest that impaired set-shifting and decision making are stable traits in women with AN. Because individual differences within these groups were large, a rigid thinking style is only present in a (sub)- population of ill and recovered women. Decision-making performance is not related to a rigid thinking style, but further research in this area is warranted. © 2012 by Wiley Periodicals, Inc. Source

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