Utkal University is the oldest university in Odisha and the 17th oldest university in India located at the heart of the capital city Bhubaneswar. It is a teaching-cum-affiliating university that has produced some of the best brains in Odisha. There are at present 26 post-graduate departments at the university campus for studies and research in various disciplines of Science, Humanities, Business Administration, Social Science, Law, and Commerce. There are nearly 3,000 students in the post-graduate departments at Vani Vihar. This is the largest affiliating university in the country with 267 affiliated general colleges, 15 law colleges, 6 medical and pharmacy colleges. Wikipedia.
Subudhi U.,Utkal University |
Chainy G.B.N.,Utkal University
Chemico-Biological Interactions | Year: 2010
Earlier we have demonstrated that oral supplementation of vitamin E and curcumin alleviates hyperthyroidism-induced oxidative stress and distorted histoarchitecture in rat liver . To delineate the underlying mechanism of protection, the present study was undertaken to investigate the regulatory role of vitamin E and curcumin on antioxidant gene (AOG) expression in hyperthyroid rat liver. Adult male rats were rendered hyperthyroid by administration of 0.0012% l-thyroxine in their drinking water, while vitamin E (200 mg/kg body weight) and curcumin (30 mg/kg body weight) were supplemented orally for 30 days. l-Thyroxine-induced hyperthyroidism decreased the transcript levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx1) and glutathione reductase (GR) in liver. Alleviated message levels of SOD and CAT were noticed following simultaneous administration of curcumin and vitamin E to hyperthyroid rats. Moreover vitamin E or curcumin treatment ameliorated GPx1 and GR mRNA levels. Translated products of AOGs showed differential expression in the liver of hyperthyroid rats, where Cu/Zn SOD (SOD1), CAT and GR were decreased in contrast to Mn SOD (SOD2) and GPx1. Vitamin E administration was able to alleviate SOD1, CAT and GR translated products while only CAT protein was restored to normal level by curcumin. Co-administration of both antioxidants normalized GPx1 protein expression. Interestingly decreased activities of cytosolic CAT and GPx1 were alleviated following vitamin E and curcumin administration. Increased mitochondrial SOD1 and decreased GR activities were also normalized by antioxidant treatment. Above findings suggest that administration of vitamin E and curcumin may alleviate the hepatic AOG expression in hyperthyroid rats. © 2009 Elsevier Ireland Ltd. All rights reserved.
Acharya S.,Utkal University |
Patra S.,Utkal University
Carbohydrate Polymers | Year: 2014
This study was to optimize HPMC K4M and carbopol 934 concentration in the development of non-effervescent floating tablets (NEFTs) of glipizide as model drug using 32 factorial design. The time required for releasing drug of 50% and 80% and similarity factor were the target responses. HPMC K4M and carbopol 934 concentrations were the variables. The response surface methodology and optimized polynomial equations were used to select the optimal formulation with desired responses. The excipients used in tablets were compatible with glipizide as per the results of isothermal stress testing and DSC study. The drug release of entire NEFTs followed zero order kinetics and non-Fickian diffusion mechanism. Validation of the optimization technique demonstrated the reliability of the model. The optimized formulation containing 124.33 mg HPMC K4M and 25.76 mg carbopol 934 was prepared according to the software determined levels. The stability study of the optimized formulation proved the integrity of the developed formulation. © 2013 Elsevier Ltd. All rights reserved.
Mishra P.,Utkal University |
Samanta L.,Ravenshaw University
The Scientific World Journal | Year: 2012
Increased or reduced action of thyroid hormone on certain molecular pathways in the heart and vasculature causes relevant cardiovascular derangements. It is well established that hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with a faster heart rate, enhanced left ventricular systolic and diastolic function whereas hypothyroidism is characterized by the opposite changes. Hyperthyroidism and hypothyroidism represent opposite clinical conditions, albeit not mirror images. Recent experimental and clinical studies have suggested the involvement of ROS tissue damage under altered thyroid status. Altered-thyroid state-linked changes in heart modify their susceptibility to oxidants and the extent of the oxidative damage they suffer following oxidative challenge. Chronic increase in the cellular levels of ROS can lead to a catastrophic cycle of DNA damage, mitochondrial dysfunction, further ROS generation and cellular injury. Thus, these cellular events might play an important role in the development and progression of myocardial remodeling and heart failure in altered thyroid states (hypo- and hyper-thyroidism). The present review aims at elucidating the various signaling pathways mediated via ROS and their modulation under altered thyroid state and the possibility of antioxidant therapy. Copyright © 2012 Pallavi Mishra and Luna Samanta.
Dwibedy S.K.,Utkal University
Indian Journal of Marketing | Year: 2013
Efficient marketing plays an important role in increasing the producer's share in consumer's rupee and maintains the tempo of increased production. In the present study, the cost of cultivation, profit, price spread and marketing efficiency in the marketing of Brinjal in Khurdha district of Odisha were examined during the period from 2011-2012. Primary data were collected from 80 farmers through personal interview method using a specially designed pre- tested schedule. Three market channels were identified in the study area. These were Channel I: Farmer - Commission Agent-Wholesaler- Retailer- Consumer; Channel II: Farmer-Wholesaler- Retailer- Consumer and Channel III: Farmer- Organized Food Retail Chain-Consumer. The major findings revealed that the producer's share in consumer's rupee was 64.87 percent for Channel III, 49.85 percent for Channel II and 47.69 percent for Channel I. Channel III was found to be the most efficient market both by Shepherd's method and Acharya's method.
Bhanja S.,Utkal University |
Chainy G.B.N.,Utkal University
International Journal of Developmental Neuroscience | Year: 2010
The objective of the present study was to evaluate the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameters, expression of antioxidant defence enzymes, cell proliferation and apoptosis in the developing cerebellum. PTU challenged neonates showed significant decrease in serum T3 and T4 levels and marked increase in TSH levels. Significantly elevated levels of cerebellar H2O2 and lipid peroxidation were observed in 7 days old hypothyroid rats, along with increased activities of superoxide dismutase and glutathione peroxidase and decline in catalase activity. In 30 days old hypothyroid rats, a significant decline in cerebellar lipid peroxidation, superoxide dismutase and glutathione peroxidase activity and expression was observed along with an up-regulation in catalase activity and expression. Expression of antioxidant enzymes was studied by Western blot and semi-quantitative rt-PCR. A distinct increase in cell proliferation as indicated by proliferating cell nuclear antigen (PCNA) immunoreactivity was observed in the internal granular layer of cerebellum of 7 days old hypothyroid rats and significant drop in PCNA positive cells in the cerebellar molecular layer and internal granular layer of 30 days old PTU treated rats as compared to controls. In situ end labeling by TUNEL assay showed increased apoptosis in cerebellum of hypothyroid rats in comparison to controls. These results suggest that the antioxidant defence system of the developing cerebellum is sensitive to thyroid hormone deficiency and consequent alterations in oxidative stress status may play a role in regulation of cell proliferation of the cerebellum during neonatal brain development. © 2010 ISDN.
Behera S.,Utkal University |
Mohanty R.C.,Utkal University |
Ray R.C.,Central Tuber Crops Research Institute Regional Center
Applied Energy | Year: 2011
The dried spongy fruit of luffa (Luffa cylindrica L.), a cucurbitaceous crop available in abundance in tropical and sub-tropical countries has been found to be a promising material for immobilizing microbial cells. The aim of the present study was to examine the ethanol production from mahula flowers in submerged fermentation using whole cells of Saccharomyces cerevisiae immobilized in luffa sponge discs. The cells not only survived but also were physiologically active in three more cycles of fermentation without significant reduction (<5%) in ethanol production. After 96. h, there was 91.1% sugar conversion producing 223.2. g ethanol/kg flowers (1st cycle) which was 0.99%, 2.3% and 3.2% more than 2nd (221. g ethanol/kg flowers), 3rd (218. g ethanol/kg flowers) and 4th (216. g ethanol/kg flowers) cycle of fermentation, respectively. Furthermore, ethanol production by immobilized cells was 8.96% higher than the free cells. © 2010 Elsevier Ltd.
Paital B.,Utkal University |
Chainy G.B.N.,Utkal University
Ecotoxicology and Environmental Safety | Year: 2013
Studies on oxidative stress (OS) in crustacea are widely used as ecotoxicological indices to assess the environment risk produced by the impact of several stressor and pollutants. In the present study, effects of seasonality on OS physiology markers such as antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), small antioxidant molecules (ascorbic acid and reduced glutathione), oxidative stress indices (lipid peroxidation, protein carbonylation and hydrogen peroxide) and total antioxidant capacity in hepatopancreas, gills and abdominal muscle of adult mud crab Scylla serrata, sampled from Chilika lagoon of India, were determined in winter, summer and rainy seasons. Results indicate that variations in enzymatic and non-enzymatic antioxidants with relation to season were not only tissue specific but also were gender specific. The levels of OS parameters were higher in hepatopancreas in comparison to gills and abdominal muscle of the crabs in all seasons. OS indices in tissues of the crabs were mainly higher in summer season when temperature and salinity of the lagoon were high with low oxygen content. Although OS was lower in winter season and moderate in rainy season in tissues of male crabs, it was higher in gills and hepatopancreas of females in rainy season. Correlation analyses between hydrological parameters of the lagoon (temperature, salinity and dissolved oxygen content) and OS physiology parameters in tissues of crabs suggest that abiotic factors influence the levels of antioxidant enzymes and, thereby the OS status in a tissue and sex specific manner. Collectively, the results of the present work suggest that further investigation is warranted before using OS parameters in S. serrata as biomarkers to monitor estuarine environment as these are influenced by gender, tissue and season. © 2012 Elsevier Inc.
Nayak B.,Utkal University |
Jamil M.,National University of Sciences and Technology |
Jamil M.,Eurasian University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012
We study the evolution of primordial black holes by considering present universe is no more matter dominated rather vacuum energy dominated. We also consider the accretion of radiation, matter and vacuum energy during respective dominance period. In this scenario, we found that radiation accretion efficiency should be less than 0.366 and accretion rate is much larger than previous analysis by Nayak et al. (2009) . Thus here primordial black holes live longer than previous works Nayak and Singh (2011) . Again matter accretion slightly increases the mass and lifetime of primordial black holes. However, the vacuum energy accretion is slightly complicated one, where accretion is possible only up to a critical time. If a primordial black hole lives beyond critical time, then its' lifespan increases due to vacuum energy accretion. But for presently evaporating primordial black holes, critical time comes much later than their evaporating time and thus vacuum energy could not affect those primordial black holes. © 2012 Elsevier B.V.
Baliarsingh N.,CSIR - Institute of Minerals And Materials Technology |
Parida K.M.,CSIR - Institute of Minerals And Materials Technology |
Pradhan G.C.,Utkal University
Industrial and Engineering Chemistry Research | Year: 2014
To investigate the effects of divalent metal ions on the photophysical and photocatalytic properties of MII/Cr-CO3 layered double hydroxides (LDHs), we varied the MII metal ions (Co, Ni, Cu, and Zn) at a constant MII/Cr atomic ratio of 2:1. The phase structures and textural and optical properties of these catalysts were characterized by powder X-ray diffraction (PXRD), Brunauer-Emmett-Teller (BET) surface area, Fourier transform infrared (FTIR) spectroscopy, photoluminescence (PL) spectroscopy, and diffuse-reflectance UV-vis (DRUV-vis) spectroscopy. The PXRD measurements demonstrated that all of the as-synthesized LDHs had well-defined layered structures except Ni/Cr-CO3 LDH (LDH2). Optical difference spectra revealed that absorption in the visible region can be attributed to metal-to-metal charge transfer (MMCT) excitation of oxo-bridged bimetallic linkages of MII-O-CrIII in the two neighboring MO 6 octahedra. The photocatalytic performances of these catalysts were examined in the degradation of methyl orange (MO) dye under solar light irradiation. The LDH containing cobalt (i.e., LDH1) exhibited the highest photoactivity with 90% MO removal in 3 h under solar light irradiation. The excitation of MII-O-CrIII in solid solution in the visible range was demonstrated to be one of the causes of the enhanced degradation of MO. An MO degradation mechanism over MII/Cr-CO3 LDHs is proposed that is due to the formation of intermediate oxidative species such as hydroxyl radicals and superoxide radicals during the reactions. Moreover, the most active photocatalyst (LDH1) was found to be stable under repeated applications of up to four successive cycles with a nearly constant photocatalytic degradation activity. © 2014 American Chemical Society.
Paital B.,Utkal University |
Chainy G.B.N.,Utkal University
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | Year: 2010
The effects of salinity (10, 17 and 35 ppt) on O2 consumption, CO2 release and NH3 excretion by crabs and oxidative stress parameters and antioxidant defenses of its tissues were reported. An increase in salinity caused a decrease in O2 consumption and CO2 release and an increase in ammonia excretion by crabs. Lipid peroxidation, protein carbonyl, H2O2 levels and total antioxidant capacity of the tissues elevated significantly at 35 ppt salinity except in abdominal muscle where H2O2 content was low. Ascorbic acid content of tissues was higher at 17 ppt salinity than at 10 and 35 ppt salinities. With increasing salinity, a gradual decrease in SOD, an increase in catalase, no change in GPx and a decrease followed by an increase in GR activities were recorded for abdominal muscle. While for hepatopancreas, an increase followed by a decrease in SOD and catalase, decrease in GPx and GR activities were noticed with increasing salinity. In the case of gills, a decrease followed by an increase in SOD, a decrease in catalase and GPx and an increase in GR activities were noted when the salinity increased from 10 ppt to 35 ppt. These results suggest that salinity modulation of oxidative stress and antioxidant defenses in Scylla serrata is tissue specific. © 2009 Elsevier Inc. All rights reserved.