UTHealth Medical School

Houston, TX, United States

UTHealth Medical School

Houston, TX, United States
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Demuth H.-U.,Fraunhofer Institute for Cell Therapy and Immunology | Dijkhuizen R.M.,University Utrecht | Farr T.D.,University of Nottingham | Gelderblom M.,University of Hamburg | And 24 more authors.
Restorative Neurology and Neuroscience | Year: 2017

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms. This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations. © 2017 - IOS Press and the authors.


Balucani C.,SUNY Downstate Medical Center | Balucani C.,University of Perugia | Grotta J.C.,UTHealth Medical School
Neurology | Year: 2012

There is a great need for new treatments for acute ischemic stroke that will achieve greater rates of arterial recanalization and increase the population of patients who may benefit. Of several approaches under investigation, intra-arterial therapy (IAT) is the farthest along in clinical development, but experience has shown that the increased rates of recanalization achieved are not always translated to improved patient outcomes. Proper patient selection, allied to efficient strategies aiming at faster recanalization and reperfusion, may result in better clinical outcomes and more rational use of therapeutic resources. While high-tech multimodal imaging has the great promise of identifying hypoperfused but still viable brain tissue, a number of clues suggest that relatively low-tech approaches similar to those that were used to demonstrate the efficacy of systemic thrombolysis, and which have emphasized the key role of time and clinical factors such as age, glucose, stroke severity, and infarct on noncontrast CT scan, deserve greater study as an efficient way to optimize IAT. Eventually it will be a combination of predictors that will enable us to most precisely identify the best patients for IAT and any other new revascularization therapies. Copyright © 2012 by AAN Enterprises, Inc.


PubMed | Cornell College, Brain and Mind Research Institute, University of Cologne, University of Nottingham and 18 more.
Type: | Journal: Restorative neurology and neuroscience | Year: 2017

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patients outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.


Northrup T.F.,University of Texas Health Science Center at Houston | Khan A.M.,UTHealth Medical School | Jacob P.,University of California at San Francisco | Benowitz N.L.,University of California at San Francisco | And 4 more authors.
Tobacco Control | Year: 2015

Background Tobacco has regained the status of the world's number two killer behind heart/vascular disease. Thirdhand smoke (THS) residue and particles from secondhand smoke (SHS) are suspected health hazards (eg, DNA damage) that are likely to contribute to morbidity and mortality, especially in vulnerable children. THS is easily transported and deposited indoors, where it persists and exposes individuals for months, creating potential health consequences in seemingly nicotine-free environments, particularly for vulnerable patients. We collected THS data to estimate infant exposure in the neonatal ICU (NICU) after visits from household smokers. Infant exposure to nicotine, potentially from THS, was assessed via assays of infant urine. Methods Participants were mothers who smoked and had an infant in the NICU (N=5). Participants provided surface nicotine samples from their fingers, infants' crib/incubator and hospital-provided furniture. Infant urine was analysed for cotinine, cotinine's major metabolite: trans-30-hydroxycotinine (3HC) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of the nicotine-derived and tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Results Incubators/cribs and other furniture had detectable surface nicotine. Detectable levels of cotinine, 3HC and NNAL were found in the infants' urine. Discussion THS appears to be ubiquitous, even in closely guarded healthcare settings. Future research will address potential health consequences and THSreduction policies. Ultimately, hospital policies and interventions to reduce THS transport and exposure may prove necessary, especially for immunocompromised children. © 2015 by the BMJ Publishing Group Ltd.


PubMed | UTHealth Medical School, San Diego State University, San Francisco General Hospital, University of California at San Francisco and 2 more.
Type: | Journal: Tobacco control | Year: 2015

Tobacco has regained the status of the worlds number two killer behind heart/vascular disease. Thirdhand smoke (THS) residue and particles from secondhand smoke (SHS) are suspected health hazards (eg, DNA damage) that are likely to contribute to morbidity and mortality, especially in vulnerable children. THS is easily transported and deposited indoors, where it persists and exposes individuals for months, creating potential health consequences in seemingly nicotine-free environments, particularly for vulnerable patients. We collected THS data to estimate infant exposure in the neonatal ICU (NICU) after visits from household smokers. Infant exposure to nicotine, potentially from THS, was assessed via assays of infant urine.Participants were mothers who smoked and had an infant in the NICU (N=5). Participants provided surface nicotine samples from their fingers, infants crib/incubator and hospital-provided furniture. Infant urine was analysed for cotinine, cotinines major metabolite: trans-3-hydroxycotinine (3HC) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of the nicotine-derived and tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).Incubators/cribs and other furniture had detectable surface nicotine. Detectable levels of cotinine, 3HC and NNAL were found in the infants urine.THS appears to be ubiquitous, even in closely guarded healthcare settings. Future research will address potential health consequences and THS-reduction policies. Ultimately, hospital policies and interventions to reduce THS transport and exposure may prove necessary, especially for immunocompromised children.


Barbosa I.G.,Federal University of Minas Gerais | Machado-Vieira R.,University of Sao Paulo | Machado-Vieira R.,U.S. National Institutes of Health | Soares J.C.,UTHealth Medical School | Teixeira A.L.,Federal University of Minas Gerais
NeuroImmunoModulation | Year: 2014

Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD. © 2014 S. Karger AG, Basel.


Lyden P.,Cedars Sinai Medical Center | Lyden P.,University of California at San Diego | Ernstrom K.,University of California at San Diego | Cruz-Flores S.,St Louis University Medical Center | And 7 more authors.
Neurocritical Care | Year: 2012

Background: Therapeutic hypothermia is a promising neuroprotective therapy with multiple mechanisms of action. We demonstrated the feasibility of thrombolysis combined with endovascular hypothermia, but not all patients achieved effective cooling. We sought to identify the factors that determined effective cooling. Methods: In 26 patients who underwent endovascular hypothermia, we computed four measures of effective cooling: time to reach target; Area-Under-the-Curve (AUC) 34 ratio; AUC-34; and AUC-35. By multivariate regression, we examined the effects of age, weight, starting temperature, body mass index, body surface area (BSA), gender, shivering, and total meperidine dose on the four outcome measures. Results: In univariate analyses, all four outcome measures were significantly influenced by BSA (p < 0.01 in all univariate analyses). Time to reach target temperature was quicker in older patients (p < 0.01). Shivering and meperidine dose were highly intercorrelated (r = 0.6, p < 0.01) and both marginally influenced all four outcome measures. In multivariate analysis, AUC ratio and time to reach target temperature were significantly influenced by BSA (p < 0.01) and meperidine (p < 0.05); AUC-34 was influenced only by BSA (p < 0.01). The AUC-35 was influenced by BSA (p < 0.01), shivering, and total meperidine dose (p < 0.05). Conclusions: The most important determinant of effective cooling during endovascular hypothermia is BSA; larger patients are more difficult to cool and maintain in therapeutic range. Older patients cool more quickly. Shivering was well controlled by the combination of meperidine, buspirone, and surface counter-warming and only minimally influenced cooling effectiveness. Future trials of therapeutic hypothermia may include added measures to cool larger patients more effectively. © Springer Science+Business Media, LLC 2012.


Zhao Z.,UTHealth Medical School | Miki T.,UTHealth Medical School | van Oort-Jansen A.,UTHealth Medical School | Matsumoto T.,UTHealth Medical School | And 2 more authors.
Physiological Genomics | Year: 2011

There is currently much interest in clinical applications of therapeutic hypothermia. Hypothermia can be a consequence of hypometabolism. We have recently established a procedure for the induction of a reversible deep hypometabolic state in mice using 5'-adenosine monophosphate (5'- AMP) in conjunction with moderate ambient temperature. The current study aims at investigating the impact of this technology at the gene expression level in a major metabolic organ, the liver. Our findings reveal that expression levels of the majority of genes in liver are not significantly altered by deep hypometabolism. However, among those affected by hypometabolism, more genes are differentially upregulated than downregulated both in a deep hypometabolic state and in the early arousal state. These altered gene expression levels during 5'-AMP induced hypometabolism are largely restored to normal levels within 2 days of the treatment. Our data also suggest that temporal control of circadian genes is largely stalled during deep hypometabolism. © 2011 the American Physiological Society.


Dr. Todd D. Wilson is among the speakers scheduled to discuss modern developments in technology and techniques for everything from general to bariatric surgery at the Houston event HOUSTON, TX--(Marketwired - February 28, 2017) - Prominent surgeons from across the country are coming together this March to educate and showcase the latest technology and techniques in the areas of reflux and foregut, oncology, hernia, acute care, colon and rectal, and bariatric surgery at a Houston, Texas, summit. Besides presenting the latest technological and surgical advancements in the fields, surgeons and industry leaders are looking to both educate and learn from each other in a positive and entrepreneurial environment, and discuss the best ways to raise the standard and quality of care for their patients. The Summit is being jointly hosted by the University of Texas Health Science Center at Houston | McGovern Medical School and the affiliated UT MIST (Minimally Invasive Surgeons of Texas). In fact, several of UT MIST's own surgeons will be speaking at the Summit. As a professor at UTHealth Medical School, and surgeon of hernia and bariatrics, Dr. Todd D. Wilson will be speaking about a number of useful mobile apps -- primarily CeQOL, CESPA, and CeDAR -- developed by surgical tech innovation groups that can allow both hernia surgeons and their patients to assess the numerous factors that need to be assessed when a patient is being considered as a candidate for hernia repair surgeries. CeDAR, for example, is a free app on Google Play and the Apple App Store created by Carolinas Surgical Innovation Group, LLC, in conjunction with two prominent physicians. CeDAR -- short for Carolinas Equation for Determining Associated Risks -- was developed in order to predict the financial costs and risks of wound-related issues after going through a complex hernia repair surgery. These apps empower surgeons and their patients with the ability to assess and predict the outcomes of abdominal hernia surgery for each individual in a simple, calculable way, thus allowing patients to make better informed decisions about their health care. The apps also provide information on the types of hernias and what treatment options are possible for each. Dr. Todd Wilson will discuss the implications of such technology for the health care sector in general, as well as its practical uses in specific cases. To speak with him and the surgical team at UT MIST, call (713) 892-5500, or inquire for more information online. The 2017 Surgical Disruptive Technological Summit takes place between March 18 and 20 at the Marriott Marquis in Houston. Interested parties or sponsors may register for the two-day educational forum at the summit's website, where a special group hotel rate is also available. For more information on the Summit, visit www.surgicaldisruptivetechsummit.org.


PubMed | UTHealth Medical School
Type: Journal Article | Journal: Physiological genomics | Year: 2011

There is currently much interest in clinical applications of therapeutic hypothermia. Hypothermia can be a consequence of hypometabolism. We have recently established a procedure for the induction of a reversible deep hypometabolic state in mice using 5-adenosine monophosphate (5-AMP) in conjunction with moderate ambient temperature. The current study aims at investigating the impact of this technology at the gene expression level in a major metabolic organ, the liver. Our findings reveal that expression levels of the majority of genes in liver are not significantly altered by deep hypometabolism. However, among those affected by hypometabolism, more genes are differentially upregulated than downregulated both in a deep hypometabolic state and in the early arousal state. These altered gene expression levels during 5-AMP induced hypometabolism are largely restored to normal levels within 2 days of the treatment. Our data also suggest that temporal control of circadian genes is largely stalled during deep hypometabolism.

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