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Ambartsoumian G.,University of Texas at Arlington | Gouia-Zarrad R.,University of Texas at Arlington | Lewis M.A.,UT Southwestern Medical School
Inverse Problems | Year: 2010

The representation of a function by its circular Radon transform (CRT) and various related problems arise in many areas of mathematics, physics and imaging science. There has been a substantial spike of interest toward these problems in the last decade mainly due to the connection between the CRT and mathematical models of several emerging medical imaging modalities. This paper contains some new results about the existence and uniqueness of the representation of a function by its CRT with partial data. A new inversion formula is presented in the case of the circular acquisition geometry for both interior and exterior problems when the Radon transform is known for only a part of all possible radii. The results are not only interesting as original mathematical discoveries, but can also be useful for applications, e.g., in medical imaging. © 2010 IOP Publishing Ltd.

Luby-Phelps K.,UT Southwestern Medical School
Molecular Biology of the Cell | Year: 2013

From the point of view of intermolecular interactions, the cytoplasmic space is more like a crowded party in a house full of furniture than a game of tag in an empty field. Understanding the physical chemical properties of cytoplasm is thus of key importance for understanding cellular function. This article attempts to provide an entrée into the current literature on this subject and offers some general guidelines for thinking about intracellular biochemistry. © 2013 Luby-Phelps.

Ludwig I.H.,Eye Center South | Clark R.A.,University of California at Los Angeles | Stager Sr. D.R.,UT Southwestern Medical School
Journal of AAPOS | Year: 2013

Five new strabismus surgical procedures were developed by the authors and were presented as a workshop at the AAPOS annual meeting of the American Association for Pediatric Ophthalmology and Strabismus. They are summarized here to introduce these methods to the reader and provide surgeons with more options in approaching difficult strabismus problems. Diagnosis and correction of consecutive strabismus attributable to stretched scar is discussed. The pulley posterior fixation procedure is a unique approach to correct high accommodative convergence or to augment a maximal medial rectus recession. Diagnosis and repair of the partial avulsion (flap tear) of a rectus muscle allows correction of some restrictive strabismus following blunt trauma. The nasal myectomy of the inferior oblique muscle corrects persistent inferior oblique overaction without sacrificing the tether effect gained by a previous anterior transposition of the inferior oblique. The full advancement of the superior oblique tendon offers another option to strengthen a weak superior oblique muscle. © 2013 by the American Association for Pediatric Ophthalmology and Strabismus.

Nguyen H.,Histology and Immunohistochemistry | John G.B.,UT Southwestern Medical School | Scherer P.E.,Touchstone Diabetes Center
Aesthetic Surgery Journal | Year: 2014

Background: Light and electron microscopy have not identified a distinct anatomical structure associated with either skin wrinkles or creases, and a histological difference between wrinkled and adjacent skin has not been identified. Objectives: The authors investigate whether facial wrinkles are related to underlying lymphatic vessels and perilymphatic fat. Methods: Lymphatic vessels with a specialized tube of perilymphatic fat were identified beneath palmar creases. Sections of skin, adipose tissue, and muscle were harvested from each of 13 cadavers. Three sites were investigated: the transverse forehead crease, lateral orbicularis oculi wrinkle (crows feet), and the nasojugal crease. The tissue was paraffin embedded and processed. Two-step indirect immunohistochemistry was performed, and images were examined using laser confocal microscopy. Measurements were taken with software. Results: Every wrinkle examined was found above and within 1 mm of a major lymphatic vessel and its surrounding tube of adipose tissue. The results satisfied our null hypothesis and were statistically significant. Lymphatic vessels were identified by positive immunofluorescence as well as histological criteria. These findings have been further validated by fluorochrome tracer studies. Conclusions: An anatomical basis for wrinkles was identified among the specimens studied. Lymphatic vessels, along with the surrounding distinct perilymphatic fat, traveled directly beneath wrinkles and creases. Lymphatic dysregulation leads to inflammation, scarring, and fibrosis, but inadvertent injection of these vessels can be avoided with anatomical knowledge. © 2013 The American Society for Aesthetic Plastic Surgery, Inc.

Tamminga C.A.,Southwestern Medical Center | Pearlson G.,Hartford Hospital Yale | Keshavan M.,Harvard University | Sweeney J.,UT Southwestern Medical School | And 2 more authors.
Schizophrenia Bulletin | Year: 2014

Bipolar and schizophrenia network for intermediate phenotypes is a network of investigator-driven laboratories focused on developing phenotypes, genotypes, and biomarkers for psychosis. Over the last 5 years, the consortium has accomplished a dense phenotyping protocol using probands with a lifetime history of psychosis, their relatives, and healthy controls. This has established a library of biomarker information on individuals with schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. The founding goal of establishing disease biomarkers for current psychotic diagnoses has been poorly met, because the cognitive, electrophysiologic, eye movement, and brain imaging biomarkers did not regularly discriminate individuals with different DSM psychosis diagnoses. In future, we will use this biomarker information to establish a pathway to biomarker-based classification in psychoses. © 2014 © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.

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