Monitoring trends in N-terminal pro-B-type natriuretic peptide (NT-proBNP) in acute brain disease [Sledování dynamiky N-terminálního natriuretického propeptidu typu B (NT-proBNP) u akutního onemocnění mozku]
Spatenkova V.,Neurocentrum JIP |
Skrabalek P.,Oddeleni Klinicke Biochemie |
Kazda A.,Ustav Klinicke Biochemie Laboratorni Diagnostiky |
Suchomel P.,Neurocentrum JIP
Klinicka Biochemie a Metabolismus | Year: 2010
Objective: Monitoring trends in N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in relation to serum sodium and serum osmolality in patients with acute brain diseases. Design: Retrospective study. Setting: Neurological- neurosurgical care unit, Regional Hospital. Material and methods: We analyzed in 24-hour intervals over three days the serum NT-proBNP, serum sodium (SNa+) and serum osmolality (SOsm) in 13 patients with acute brain diseases (mean Glasgow Coma Scale 14 ± 1). All patients were classified as New York Heart Association I and had creatinine clearance ≥1.5 ml/s. We evaluated the trends of measured parameters, relation of NT-proBNP to cut-off (14.8 pmol/l and 125 pg/ml) and to the measured parameters. Results: In the study no significant change to the NT-proBNP in time (p = 0.121) was found. Neither were significant changes found over the course of three days in SNa+ (142.4 ± 4.2, 143.5 ± 4.9, 144.5 ± 7.6 mmol/l, p = 0.551) and SOsm (296.6 ± 9.9, 294.3 ± 6.9, 292.4 ± 12.8 mmol/kg, p = 0.065). Levels of NT-proBNP from the first (p=0.006) and third day (p = 0.027) were statistically significantly higher than the cut-off. On the second day (p = 0.058) the values were slightly above the border of significance. There was a significant correlation between NT-proBNP on days 2 and 3 (p = 0.021), NT-proBNP on day 2 and SOsm on day 3 (p = 0.0018). Conclusion: The results of this study did not show a statistically significant trend in NT-proBNP in patients with acute brain disease. Significantly higher NT-proBNP values than the cut-off on day 1 and 3 did not lead to the occurrence of hyponatremia and serum hypoosmolality.