Ostrava, Czech Republic
Ostrava, Czech Republic

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Splichalova A.,Zdravotni Ustav Se Sidlem V Ostrave | Tomaskova H.,Zdravotni Ustav Se Sidlem V Ostrave | Jirak Z.,Ustav Fyziologie A Patofyziologie | Lehocka H.,Zdravotni Ustav Se Sidlem V Ostrave | And 10 more authors.
Pracovni Lekarstvi | Year: 2010

The aim of this study was to compare lung cancer risk in workers with acknowledged form of silicosis and non-exposed general population of the Czech Republic. The study sample included 797 males registered with silicosis in the National Registry of Occupational Diseases in 1992-2001. The basic data on study sample obtained from the National Registry of Occupational Diseases were combined with data from the National Cancer Registry and the National Population Registry. Carcinogenic risk of the study sample in comparison with Czech male population was evaluated by calculation of Standardized Incidence Ratio ( SIR) in 1992-2006. The average age of the study sample in time of diagnosed silicosis was 60.4 years; the average exposure was 24.2 years. In 1992-2006, 61 workers developed lung cancer. Significantly higher lung cancer risk (SIR = 2.81 ; 95% Cl 2.1-3.6) was confirmed in workers with silicosis compared to the general Czech male population. The highest lung cancer risk was identified in ore-miners and breakers, metal workers, and metallurgist-founders. Significantly higher proportion of lung cancer was found in a group of smokers and ex-smokers in comparison with non-smokers (p < 0.01). No significant relationship was identified either between lung cancer incidence and estimated lifetime exposure to silica dust or between lung cancer incidence and degree of severity of silicosis by the ILO classification in the study sample.


Buzgova R.,Ustav osetrovatelstvi a porodni asistence | Holeczy P.,Katedra chirurgickych oboru | Buzga M.,Ustav fyziologie a patofyziologie
Endoskopie | Year: 2011

The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy on the subjective perception of health-related quality of life in women. Methods: The research sample consisted of 26 women after laparoscopic sleeve gastrectomy. A standardized questionnaire to measure health-related quality of life WHOQOL-BREF was used for data collection. All women completed a questionnaire three times: 1 month before surgery, 3 and 6 months after surgery. Results: Before surgery, women with morbid obesity (especially up to 45 years) showed statistically significant lower health-related quality of life through psychological health (p=0.0001), physical health (p=0.0001), overall health-related quality of life (p=0.0017) and health satisfaction (p=0.0010) compared with population standard. Already after 3 months after the operation there was significant improvement in health-related quality of life in these domains as well as in individual items (p=0.0010). 6 months after the operation surgery patients showed similar average values of health-related quality of life as population standards. At the same time there was a statistic ally significant reduction in BMI (p <0.001). Conclusion: Laparoscopic sleeve gastrectomy is effective for weight reduction as well as for positive changes in health-related quality of life in women with morbid obesity.


Mizerova V.,UStav Fyziologie a Patofyziologie | Buzga M.,UStav Fyziologie a Patofyziologie | Machytka E.,University of Ostrava | Seidlerova A.,UStav Fyziologie a Patofyziologie
Prakticky Lekar | Year: 2015

Purpose: The effects of the intragastric balloon MedSil® on anthropometric measures and dietary habits were evaluated in this study. Methods: Twenty-four patients aged from 24 to 61 with BMI 42 ± 10 kg/m2 underwent insertion of the intragastric balloon MedSil® and following a clinical exam: body height, weight, BMI and body composition scan by dual-energy X-ray absorptiometry (device Discovery A, Hologic, USA). Dietary habits were found out by the questionnaire and 4-7 day eating records. Results: Six months after insertion of the MedSil® balloon, an average body weight reduction of 10.1 kg (p < 0.001), body mass index reduction of 3,8 kg/m2 (p < 0.001), fat mass reduction of 7.5 kg and fat free mass reduction of 2.6 kg were found. Average daily energy intake was 6474 ± 2683 kJ. Patient's average daily intake of protein, Vitamin C and vitamin B12 was adequate. Average daily intake of fibre, iodine and folic acid was low. Patients reported greater regularity of meals, more servings per day, reduced appetite and positive changes in food consumption. Conclusion: Intragastric balloon insertion helped to improve patient's dietary habits and led to positive changes of body composition during next six months.

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