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Prague, Czech Republic

Franc A.,University of Veterinary And Pharmaceutical Sciences Brno | Vetchy D.,University of Veterinary And Pharmaceutical Sciences Brno | Smilkova L.,University of Veterinary And Pharmaceutical Sciences Brno | Rabiskova M.,University of Veterinary And Pharmaceutical Sciences Brno | Kratochvil B.,Ustav chemie pevnych latek
Chemicke Listy | Year: 2012

This review describes a new trend in the formulation of dosage forms containing poorly water-soluble drugs - lipophilic solutions, dispersions, liposomes and nanoparticles - dealing also with their composition and manufacture. The dispersions are further divided into nonemulsifying, self-emulsifying, self-microemulsifying and self-nanoemulsifying drug delivery systems. The cited systems are able to form micro- and nanoemulsions in contact with gastric juices. Formulations containing lipophilic nanoparticles as well as micro- and nanoemulsions are easily absorbed. A system classifying lipid formulations according to the drug composition is also described. The system enables the taxonomy of lipophilic drugs to be made; it also tries to describe their further metabolic ways in the organism. Source


Simek M.,Ustav chemie pevnych latek | Grunwaldova V.,Zentiva | Kratochvil B.,Ustav chemie pevnych latek
Chemicke Listy | Year: 2014

The particle size and shape of raw materials influence the manufacture and behavior of solid dosage forms. The most widely used methods of particle size measurement are laser diffraction and image analysis. These methods are based on different principles and measurement ranges. Only the results obtained by the same method under the same conditions can be compared. Laser diffraction is significantly faster if a validated method is known. The method is defined for every raw material to guarantee reproducibility of measurement. Image analysis is inexpensive and does not require the validated method. Shape information is easily provided by image analysis. Laser diffraction is a suitable method for routine quality control. Image analysis is an optimal technique for development of pharmaceuticals. Source


Seilerova L.,Ustav chemie pevnych latek | Brusova H.,Zentiva | Kratochvil B.,Ustav chemie pevnych latek
Chemicke Listy | Year: 2011

Pharmaceutical excipients may occur in polymorphs and other solid forms and as active pharmaceutical ingredients. Excipients, polymorphs or the forms are not specified in the patient information leaflets on the dosage forms. Polymorphs of lactose, mannitol and sorbitol, various forms of cellulose and its derivatives, starch forms and poly(N-vinylpyrrolidone) are discussed in detail here. Identification of polymorphs and other solid forms can be carried out by X-ray powder diffraction as well as by IR, Raman and solid-state NMR spectroscopies. Source


Gruberova L.,Ustav chemie pevnych latek | Kratochvil B.,Ustav chemie pevnych latek | Jegorov A.,R.O.S.A.
Chemicke Listy | Year: 2014

Powdery pharmaceuticals are prone to electrostatic charging due to collisions of particles and friction with device walls. The generated electrostatic charge is influenced by particle properties, processing and conditions. The charge of active particles and excipients is often inconvenient being able to cause problems in the production of solid dosage forms. The electrostatic charge of powdery particles affects properties of the materials and all procedures as the charge affects the behaviour and purity of the final dosage form. The problem of electrostatic charging of powders is more complicated when two or more compounds with different physical, chemical and dielectric properties are combined. To better understand the mechanism of electrostatic charging it is necessary to explain all the effects that contribute to charging solid active ingredients and excipients. © 2014, Czech Society of Chemical Engineering. All rights reserved. Source


Seilerova L.,Ustav chemie pevnych latek | Brusova H.,Zentiva | Kratochvil B.,Ustav chemie pevnych latek | Krejcikb L.,Zentiva
Chemicke Listy | Year: 2012

Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calori -metry (DSC) and other sensitive and specific methods. The present review deals with application of these methods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs. Source

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