Yaneva M.,USHATE Academy Ivan Penchev |
Vandeva S.,USHATE Academy Ivan Penchev |
Elenkova A.,USHATE Academy Ivan Penchev |
Nachev E.,USHATE Academy Ivan Penchev |
And 12 more authors.
Endokrinologya | Year: 2013
Introduction: Epidemiological studies on Cushing's syndrome (CS) are rare, based on a limited number of cases and most of them are out of date. The aim of the present study was to analyze the incidence and the prevalence of CS in Bulgaria and to present the basic demographic characteristics of the patients with this disease. Patients and methods: This was a retrospective study, including 633 patients with proven CS, treated in the main endocrinological clinics in the country (Sofia, Varna, Plovdiv, Stara Zagora, Pleven). Results: From a total of 633 patients, 86% (544) have been treated in the CCEG - Sofia, 8,7% (55) - in the UH "St. Marina" - Varna, 4% (26) - in the UH "Aleksandrovska" - Sofia, 1,3% (8) - in the UH "St. George" - Plovdiv, in the UH "Stara Zagora" have been treated 3 patients with CS, 2 of them have been hospitalized in the CCEG and 1 - in Plovdiv, in the UH "Dr. G. Stranski", Pleven have been treated 4 patients, al of them have been followed afterwards in the CCEG. Etiology: ACTH-dependant CS: 69,2% (Cushing's disease: 66,3%, ectopic ACTH secretion: 2,9%); ACTH-independent CS: 30,8% (adenomas: 21,5%, carcinomas: 7,2%, ACTH - independent micro and macronodular hyperplasia: 2,3%). Mean age at diagnosis was 38±13 y. Female: male ratio was 5:1 (women 84%, men 16%). The mean incidence of CS was 1,6 mln/year or 14 new cases per year. The prevalence of CS for 2010 was estimated at 32,6/mln habitants. Conclusions: In this first of its kind large clinical study, involving all the university clinics in the country, was estimated the incidence (1,6 mln/year) and the prevalence (32,6/mln habitants) of CS.