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Patent
US Government, The Regents Of The University Of California and INC Research | Date: 2016-10-25

The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.


Patent
US Government and BEAM Engineering for Advanced Measurements | Date: 2017-01-30

Pointing and positioning system of light beams and images including a plurality of cycloidal diffractive waveplates, each waveplate capable of deviating a generally broadband light beam over a predetermined angle. The lateral translation and deviation angles of the light beams are controlled by controlling the relative distance, rotational position, and the diffraction efficiency of at least one in the plurality of waveplates.


Patent
University of North Carolina at Chapel Hill, The Regents Of The University Of California and US Government | Date: 2016-12-15

Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75^(NTR )receptor molecule. Enhanced survival of neural and other cells has been observed.


A simplified method for synthesizing boron phosphide at high yields. The method requires mixing of boron phosphate and magnesium metal without diluents into a homogenous mixture, loosely packing the mixture at less than 20,000 psi and igniting the mixture using an energy input that is not greater than 20% of the reaction energy output to create a self-propagating high-temperature reaction wherein the boron phosphate and magnesium metal is completely burned during the reaction to synthesize boron phosphide at high yields.


A novel pyrotechnic composition comprising nanostructured crystalline boron phosphide and oxidizer such as potassium nitrate wherein the crystalline boron phosphide is synthesized by a self-propagating high-temperature reaction. The nanostructured crystalline boron phosphide and oxidizer pyrotechnic composition unexpectedly emits smoke and green flame upon ignition.


Patent
US Government, The Regents Of The University Of California and INC Research | Date: 2016-04-20

The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.


Patent
US Government | Date: 2016-02-15

Compositions and methods for the treatment of Chlamydial infection are disclosed. The compositions provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions, vaccines and diagnostic kits are also disclosed.


Patent
Emory University and US Government | Date: 2016-06-06

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.


Patent
US Government | Date: 2016-09-30

A system and method for maintaining the face of an optical window at a desired axial position with respect to the face of a high pressure housing, suitable for use in a high pressure optical flow cell for a real time optical particle monitoring system. The window fits within a mounting hole that extends through the pressure housing. The window has a smaller-diameter cylindrical end portion extending to the high pressure side and an opposite larger-diameter cylindrical end portion, with a shoulder between the cylindrical end portions. A threaded retaining member axially compresses a gasket, o-ring, or other compliant sealing member between the shoulder of the optical window and a corresponding shoulder in the mounting hole, creating a static seal and maintaining the high pressure face of the optical window at a desired position over a wide range of temperatures and pressures.


Patent
NthDegree Technologies Worldwide and US Government | Date: 2016-01-09

The present invention provides an electronic apparatus, such as a lighting device comprised of light emitting diodes (LEDs) or a power generating apparatus comprising photovoltaic diodes, which may be created through a printing process, using a semiconductor or other substrate particle ink or suspension and using a lens particle ink or suspension. An exemplary apparatus comprises a base; at least one first conductor; a plurality of diodes coupled to the at least one first conductor; at least one second conductor coupled to the plurality of diodes; and a plurality of lenses suspended in a polymer deposited or attached over the diodes. The lenses and the suspending polymer have different indices of refraction. In some embodiments, the lenses and diodes are substantially spherical, and have a ratio of mean diameters or lengths between about 10:1 and 2:1. The diodes may be LEDs or photovoltaic diodes, and in some embodiments, have a junction formed at least partially as a hemispherical shell or cap.

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