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Chongqing, China

Liu Y.,Urology Institute of PLA | Chen Z.,Urology Institute of PLA | Wei Q.,Chongqing Medical University | Yuan F.,Urology Institute of PLA | And 3 more authors.
Cancer Genetics | Year: 2012

We investigated two polymorphisms of xeroderma pigmentosum complementary group C (XPC) in 202 subjects with prostate cancer (PCa) and 221 healthy controls in a Chinese Han population. Genotyping was performed using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. Our results indicated that smoking is associated with an increased risk for PCa (odds ratio [OR]: 1.51; 95% confidence interval [CI]: 1.02-2.22). Subjects carrying the XPC-PAT+/+ genotype exhibited a significantly increased risk for PCa (OR: 2.11; 95% CI: 1.12-3.99). The combined subjects with either the PAT+/+ or PAT+/- genotype also exhibited a 1.54-fold increased risk associated with PCa (OR: 1.54; 95% CI: 1.04-2.26). Moreover, smokers with PAT+/- or PAT+/+ had a higher risk for PCa (OR: 1.98; 95% CI: 1.08-3.64; P = 0.026 and OR: 3.56; 95% CI: 1.45-8.76; P = 0.004, respectively) compared with never smokers with the PAT-/- genotype. Analyses of the XPC Lys939Gln polymorphism did not show an association with PCa risk. Our findings support the hypothesis that XPC-PAT polymorphisms may contribute to the risk of developing PCa. More important, an elevated risk of PCa associated with a gene-environment (smoking) interaction was determined in a Chinese population. © 2012 Elsevier Inc. Source

Liu Y.,Urology Institute of PLA | Wang H.,Chongqing Medical University | Lin T.,Sun Yat Sen University | Wei Q.,Chongqing Medical University | And 5 more authors.
Oncology Reports | Year: 2012

Inherited polymorphisms in the XPC gene that lead to a reduction in DNA repair capacity may increase susceptibility to bladder cancer. We investigated three polymorphisms of the XPC gene (PAT, Ala499Val and Lys939Gln) in 600 subjects with bladder cancer and in 609 healthy controls by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a Chinese Han population. Smoking was associated with a significant increase in the risk for bladder cancer (OR, 2.48; 95% CI, 1.91-3.21). The risk was greater among heavy smokers (OR, 3.09, 95% CI, 2.24-4.25) compared to light smokers (OR, 1.91, 95% CI, 1.37-2.68). In three polymorphisms of XPC, only the XPC-PAT variant genotype exhibited a significantly increased risk for bladder cancer. When the total smoking exposure-gene interaction was examined, the three polymorphisms did not exhibit any significant effect in never smokers but a significant dose-response association in light or heavy smokers. Especially, the bladder cancer risk was significantly elevated among the polymorphisms of XPC-PAT (+/-) (OR, 2.56, 95% CI, 1.56-4.21, P<0.001; OR, 3.41, 95% CI, 2.19-5.29, P<0.001) and XPC-PAT (+/+) (OR, 3. 00, 95% CI, 1.31-6.88, P=0.009; OR, 6. 78, 95% CI, 3.00-15.54, P<0.001) with either light or heavy smoking exposure, respectively. XPC-PAT polymorphisms contribute to the risk for developing bladder cancer and an elevated risk of bladder cancer was significantly associated with the gene-environment (smoking) interaction in a Chinese Han population. Source

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