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Yekaterinburg, Russia

Melnikov D.Yu.,Urals State Medical Academy
Voprosy Onkologii

Our program has facilitated access to medical aid making earlier treatment of breast cancer possible. The morbidity rates in a city district being 1.5 times those of the metropolitan area, with 52-62% of early cancers among them, organ-saving operations rose from 3-5% to 16-17%. As a result, the 12-month mortality rate was 7.2%, while overall and relapse-free survival - 70.6 and 68.7%, respectively, which was comparable with results reported from advanced onco-centers. Source

Shklyar T.F.,Ural Federal University | Safronov A.P.,Ural Federal University | Toropova O.A.,Urals State Medical Academy | Pollack G.H.,University of Washington | Blyakhman F.A.,Ural Federal University

Mechanical and electrical properties of a synthetic polyelectrolyte hydrogel considered as a model of the cytoskeletal gel were studied. Hydrogels were synthesized from polymethacrylic acid by radical polymerization in aqueous solution. The electrical charge was introduced into the gel network by partial neutralization of monomer acids with magnesium hydroxide. Through the use of a motor, triangular longitudinal (axial) deformations were applied to gel samples. Simultaneously, the electrochemical (Donnan) potential of the gel was measured using conventional microelectrodes. We found that: (1) the Young modulus of the gel is 0.53 kPa; (2) at a given deformation velocity, the extent of gel deformation closely correlates with the gel potential; and (3) at the same level of gel deformation, the lower the deformation velocity, the higher the relative change of gel potential. These findings show a striking similarity to the data obtained in living cells, particularly in cardiac myocytes. A hypothesis involving the deformation-induced solvent migration from the gel to the surrounding solution is considered. It is concluded that the physicochemical features of the cytoskeletal gel may play a role in determining the mechanoelectric properties of excited cells. © 2010 Pleiades Publishing, Ltd. Source

Sidorenko S.V.,St. Petersburg State Medical Academy | Savinova T.A.,National Agency of Clinical Pharmacology and Pharmacy | Ilyina E.N.,Karpov Institute of Physical Chemistry | Syrochkina M.A.,Urals State Medical Academy
Antibiotiki i Khimioterapiya

Large-scale antipneumococcal vaccination is followed by changes in the serotype composition and level of antibiotic resistance in pneumococci. Hie aim of the study was to evaluate the serotype composition and population pattern of pneumococci with lower susceptibility to penicillin before large-scale antipneumococcal vaccination. Among 260 Streptococcus pneumoniae strains isolated in the Russian Federation within 2003-2007, serotypes 23F (37.2%) and 19F (13.9%) were the most frequent ones. 19.3% of the isolates belonged to serogroup 6,3.6% of the isolates each belonged to serotype 3 and serogroup 18,4.9% of the isolates belonged to serotype 14 and 2.2% of the isolates belonged to serotype 19A. 66.8% of the isolates belonged to serotypes of the 7-valent conjugated pneumococcal vaccine, 67.3 and 82.1% of the isolates belonged to the 10- and 13-valent conjugated pneumococcal vaccines respectively. Hie isolates with lower susceptibility to penicillin were characterized by significant clonality and 56.9% of them belonged to 4 global clonal complexes (CC81, CC156, CC320 and CC31S). Inclusion of the conjugated antipneumococcal vaccine to the National Vaccination Time-Table of the Russian Federation could promote lower levels of antibiotic resistance in pneumococci. Source

Shklyar T.F.,Ural Federal University | Toropova O.A.,Urals State Medical Academy | Safronov A.P.,Ural Federal University | Pollack G.H.,University of Washington | Blyakhman F.A.,Ural Federal University

A physical model of the cytoskeleton based on synthetic polyelectrolyte hydrogel of polymethacrylic acid has been proposed. From the physicochemical point of view, the structures of polyelectrolyte gel and the cytoskeleton show a high degree of similarity. It has been shown that polyelectrolyte gel can shorten and produce mechanical stress in response to changes in the composition of the surrounding solution. The mechanical properties of the model gel have been evaluated: Young modulus (2-6 kPa), stress relaxation time (0. 1-1 s), and apparent viscosity (0. 3-3 kPa s). The viscoelastic properties of the gel depend on the degree of its swelling. It has been demonstrated that the mechanical properties of gels of polymethacrylic acid are close to those of biological objects. © 2011 Pleiades Publishing, Ltd. Source

Ponomarev A.V.,RAS Institute of High Temperature Electrochemistry | Gusev A.I.,RAS Institute of High Temperature Electrochemistry | Pedos M.S.,RAS Institute of High Temperature Electrochemistry | Sergeev A.G.,Urals State Medical Academy | Ustyuzhanin A.V.,Urals State Medical Academy
Digest of Technical Papers-IEEE International Pulsed Power Conference

Within this research the damping oscillation pulses solid-state generator based on the pulsed excitation of the oscillating circuit has been developed and experimentally studied. Output harmonic voltage oscillations frequency reaches a few megahertz, while the pulse repetition rate is up to 1 kHz. Output pulse repetition rate of the generator defines power consumption from the supply main, which does not exceed 700 W, at the same time maximum peak power of the output pulses reaches several hundred kilowatts. A high-frequency transformer is used in the output stage of the generator. Thanks to using the transformer it is possible to match an impedance of the generator with different loads by simple changing of the windings rate. In present research the generator was used for excitation of a corona and DBD discharges in air, created for surface decontamination. Within this paper the electrical circuit diagram and principle of the generator operation as well as surface decontamination experimental results are described. © 2013 IEEE. Source

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