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Perpignan, France

Cenk M.,University of Waterloo | Hasan M.A.,University of Waterloo | Negre C.,UPVD | Negre C.,CNRS Montpellier Laboratory of Informatics, Robotics and Microelectronics
IEEE Transactions on Computers | Year: 2014

Some applications like cryptography involve a large number of multiplications of binary polynomial. In this paper, we consider two-, three-, and four-way methods for parallel implementation of binary polynomial multiplication. We propose optimized three-and four-way split formulas which reduce the space and time complexity of the best known methods. Moreover, we present a block recombination method which provides some further reduction in the space complexity of the considered two-, three-, and four-way split multipliers. © 2013 IEEE.

Thomas F.,IRD Montpellier | Fisher D.,CREEC | Fisher D.,French National Center for Scientific Research | Fisher D.,Montpellier University | And 59 more authors.
Evolutionary Applications | Year: 2013

Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer. © 2012 The Authors. Published by Blackwell Publishing Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Marcou O.,UPVD | Goyet C.,UPVD | Guglielmi V.,UPVD | Touratier F.,UPVD | Savy J.-P.,UPVD
Marine Environmental Research | Year: 2016

Factors controlling ocean acidification and its temporal variations were studied over the 1995-2011 period at the Dyfamed site at 10 m depth, in the North Mediterranean Sea. The results indicated a mean annual decrease of 0.003 ± 0.001 pH units on the seawater scale. The seasonal variability was characterized by a pH decrease during springtime and a strong pH increase in late fall. Anthropogenic CO2 (CANT) absorption by the ocean was the key driver of seawater acidification in this region, accounting for about 70% of the observed drop in pH, followed by water temperature (about 30%). The total inorganic carbon (CT) data showed a CT increase of 30.0 ± 1.0 μmol kg-1 per decade. This decadal increase is mainly due to the CANT penetration (43.2 μmol kg-1 per decade) in surface waters, which is mitigated for by relatively small opposing changes in CT due to physical and biological processes. © 2016 Elsevier Ltd.

Pujo-Pay M.,French National Center for Scientific Research | Pujo-Pay M.,University Pierre and Marie Curie | Conan P.,French National Center for Scientific Research | Conan P.,University Pierre and Marie Curie | And 10 more authors.
Biogeosciences | Year: 2011

This paper provides an extensive vertical and longitudinal description of the biogeochemistry along an East-West transect of 3000 km across the Mediterranean Sea during summer 2008 (BOUM cruise). During this period of strong stratification, the distribution of nutrients, particulate and dissolved organic carbon (DOC), nitrogen (DON) and phosphorus (DOP) were examined to produce a detailed spatial and vertically extended description of the elemental stoichiometry of the Mediterranean Sea. Surface waters were depleted in nutrients and the thickness of this depleted layer increased towards the East from about 10 m in the Gulf of Lion to more than 100 m in the Levantine basin, with the phosphacline deepening to a greater extent than that for corresponding nitracline and thermocline depths. We used the minimum oxygen concentration through the water column in combination with 2 fixed concentrations of dissolved oxygen to distinguish an intermediate layer (Mineralization Layer; ML) from surface (Biogenic Layer; BL), and deep layers (DL). Whilst each layer was represented by different water masses, this approach allowed us to propose a schematic box-plot representation of the biogeochemical functioning of the two Mediterranean basins. Despite the increasing oligotrophic nature and the degree of P-depletion along the West to East gradient strong similarities were encountered between eastern and western ecosystems. Within the BL, the C:N:P ratios in all pools largely exceeded the Redfield ratios, but surprisingly, the nitrate vs. phosphate ratios in the ML and DL tended towards the canonical Redfield values in both basins. A change in particulate matter composition has been identified by a C increase relative to N and P along the whole water column in the western basin and between BL and ML in the eastern one. Our data showed a noticeable stability of the DOC:DON ratio (12-13) throughout the Mediterranean Sea. This is in good agreement with a P-limitation of microbial activities but in contradiction of the accepted concept that N is recycled faster than C. The western and eastern basins had similar or close biological functioning. Differences come from variability in the allochtonous nutrient sources in terms of quantity and quality, and to the specific hydrodynamic features of the Mediterranean basins. © Author(s) 2011.

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