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News Article | February 15, 2017
Site: cerncourier.com

Completion of the preliminary design phase for the High-Luminosity LHC last year paves the way for civil-engineering work to begin. Le HL-LHC sera composé de plusieurs technologies et aimants innovants, et ces nouveaux éléments de l’accélérateur auront besoin de services supplémentaires tels que transmission de courant, distribution électrique, refroidissement, ventilation et cryogénie. Afin d’héberger les nouvelles infrastructures et les nouveaux éléments, des structures de génie civil, notamment des bâtiments, des puits, des cavernes et des galeries souterraines sont nécessaires. L’achèvement, l’année passée, de la phase de conception préliminaire du HL-LHC a permis le commencement des travaux de génie civil, et des contrats avec des entreprises externes vont à présent être conclus. The High-Luminosity LHC (HL-LHC) project at CERN is a major upgrade that will extend the LHC’s discovery potential significantly. Approved in June 2014 and due to enter operation in the mid-2020s, the HL-LHC will increase the LHC’s integrated luminosity by a factor 10 beyond its original design value. The complex upgrade, which must be implemented with minimal disruption to LHC operations, demands careful study and will take a decade to achieve. The HL-LHC relies on several innovative and challenging technologies, in particular: new superconducting dipole magnets with a field of 11 T; highly compact and ultra-precise superconducting “crab” cavities to rotate the beams at the collision points and thus compensate for the larger beam crossing angle; beam-separation and recombination superconducting dipole magnets; beam-focusing superconducting quadrupole magnets; and 80 m-long high-power superconducting links with zero energy dissipation. These new LHC accelerator components will be mostly integrated at Point 1 and Point 5 of the ring where the two general-purpose detectors ATLAS and CMS are located (see diagram). The new infrastructure and services consist mainly of power transmission, electrical distribution, cooling, ventilation, cryogenics, power converters for superconducting magnets and inductive output tubes for superconducting RF cavities. To house these large elements, civil-engineering structures including buildings, shafts, caverns and underground galleries are required. The definition of the civil engineering for the HL-LHC began in 2015. Last year, the completion of a concept study allowed CERN to issue a call for tender for two civil-engineering consultant contracts, which were adjudicated in June 2016. These consultants are in charge of the preliminary, tender and construction design phases of the civil-engineering work, in addition to managing the construction and defect-liability phase. At Point 1, which is located in Switzerland just across from the main CERN entrance, the consultant contract involves a consortium of three companies: SETEC TPI (France), which is the consortium leader, together with CSD Engineers (Switzerland) and Rocksoil (Italy). A similar consortium has been appointed at Point 5, in France. Here, the consultant contract is shared between consortium-leader Lombardi (Switzerland), Artelia (France) and Pini Swiss (Switzerland). In November 2016, the two consultant consortia completed the preliminary design phase including cost and construction-schedule estimates for the civil-engineering work. In parallel with the preliminary design, and with the help of external architects, CERN has submitted building-permit applications to the Swiss and French authorities with a view to start construction work by mid-2018. CERN has also performed geotechnical investigations to better understand the underground conditions (which consist of glacial moraines overlying a local type of soft rock called molasse), and has placed a contract with independent engineers ARUP (UK) and Geoconsult (Austria). These companies will confirm that the consultant designs have been performed with the appropriate skill, care and diligence in accordance with applicable standards. In addition, a panel comprising lawyers, architects and civil engineers is in place to resolve any disputes between parties. At ground level, the HL-LHC civil engineering consists of five buildings at each of the two LHC points, technical galleries, access roads, concrete slabs and landscaping. At each point, the total surface corresponds to about 20,000 m2 including 3300 m2 of buildings. A cluster of three buildings is located at the head of the shaft and will house the helium-refrigerator cold box (SD building, see images above), water-cooling and ventilation units (SU building) and also the main electrical distribution for high and low voltage (SE building). Completing the inventory at each point are two stand-alone buildings that will house the primary water-cooling towers (SF building) and the warm compressor station of the helium refrigerator (SHM building). Buildings housing noisy equipment (SU, SF, SHM) will be constructed with noise-insulating concrete walls and roofs. In terms of underground structures, the civil-engineering work consists of a shaft, a service cavern, galleries and vertical cores (see image above left). The total volume to be excavated is around 50,000 m3 per point. The PM shaft (measuring 9.7 m in diameter and 70–80 m deep) will house a secured access lift and staircase as well as the associated services. The service cavern (US/UW, measuring 16 m in diameter and 45 m long) will house cooling and ventilation units, a cryogenic box, an electrical safe room and electrical transformers. The UR gallery (5.8 m diameter, 300 m long) will house the power converters and electrical feed boxes for the superconducting magnets as well as cryogenic and service distribution. Two transverse UA galleries (6.2 m diameter, 50 m long) will house the RF equipment for the powering and controls of the superconducting crab cavities. At the end of the UA galleries, evacuation galleries (UPR) are required for personnel emergency exits. Two transversal UL galleries (3 m diameter, 40 m long) will house the superconducting links to power the magnets and cryogenic distribution system. Finally, the HL-LHC underground galleries are connected to the LHC tunnel via 16 vertical cores measuring 1 m in diameter and approximately 7 m long. The next important milestone will be the adjudication in March 2018 of the two contracts (one per point) for the civil-engineering construction work. In December 2016, CERN launched a market survey for the construction tender, which will be followed by invitations to tender to qualified firms by June 2017. The main excavation work, which may generate harmful vibrations for the LHC accelerator performance, must be performed during the second long shutdown of the LHC accelerator scheduled for 2019–2020. Handover of the final building is scheduled by the end of 2022, while the vertical cores connecting the HL-LHC galleries to the LHC tunnel will be constructed at the start of the third LHC long shutdown beginning in 2024. Realising the HL-LHC is a major challenge that involves more than 25 institutes from 12 countries, and in addition to civil-engineering work it demands several cutting-edge magnet and other accelerator technologies. The project is the highest priority in the European Strategy for Particle Physics, and will ensure a rich physics programme at the high-energy frontier into the 2030s.

The findings could greatly speed scientists' ability to map gene interactions and responses to environmental stimuli to advance understanding of healthy gene networks and how they go awry in the context of disease. Described in two co-authored papers in the Dec. 15 issue of Cell, one led by Broad Institute researchers and one led by UCSF researchers, the Perturb-seq platform uses single-cell RNA sequencing to measure the effects of many CRISPR-based perturbations on large numbers of cells. The method can be used in many experimental applications, such as exploring the functional impact of genetic risk factors from genomic studies more efficiently than has been previously possible, or looking at genes mutated in cancer cells. Working collaboratively, the Broad and UCSF teams used Perturb-seq to make new discoveries about, respectively, the immune response in dendritic cells, a cell type that acts as a critical messenger within the immune system, and the unfolded protein response, a cellular stress pathway implicated in a number of neurodegenerative disorders, demonstrating the potential of this platform to yield insight on a variety of biological questions. "In perturb-Seq, we combined pooled CRISPR screens with the information-rich readout of droplet-based single-cell RNA sequencing, to give us a powerful tool that dramatically increases the scope of what we can learn from functional genomic screens about how circuits are wired inside cells," said Aviv Regev, PhD, senior author of the Broad-led study, a professor of biology at MIT, a core faculty member at the Broad, and a Howard Hughes Medical Institute investigator. "In particular, we can understand how 'the whole is greater than the sum of its parts,' that is, why perturbing two different genes together gives an effect that is different than perturbing each of them alone. This will help us predict better which genes to target in disease as we develop therapies." "Perturb-seq brings two technologic advances – CRISPR-based perturbations and massively parallel single-cell RNA sequencing – together in a way that we think will greatly speed our ability to understand how different genes that encode for the components of cells are normally wired together, and what goes wrong in human disease," said Jonathan Weissman, PhD, a professor of cellular and molecular pharmacology at UCSF, a Howard Hughes Medical Institute investigator, and senior author of the UCSF-led study. The design of a robust cell barcoding strategy was also employed to allow the researchers to identify specific perturbations that have been performed on cells within pooled experiments after the fact, while measuring at the same time the effect of those perturbations on the mRNA transcripts in the cell. After an experimental treatment, such as immune stimulation or cellular stress, the cells can be subjected to droplet-based single-cell RNA sequencing to read out both the transcriptional profiles and barcodes' identities. Each cell's transcriptional profile is associated with the one or more genetic perturbations delivered to it by indexing both the cell's mRNA and the barcode identity. "Functional genomics studies can shed light on the connection between genotype and phenotype, but we'd like to also understand the mechanistic relationships between the two," said Atray Dixit, co-first author of the Broad-led study and a graduate student at MIT. "Looking at the RNA level is a great place to start." In the Broad-led experiments, researchers used CRISPR/Cas9 nucleases to cut DNA and inactivate genes for transcription factor proteins (TFs) involved in the immune response in dendritic cells, and to inactivate genes for TFs and cell cycle regulators in a cancer cell line. Perturb-seq accurately identified individual gene targets, gene signatures, and cell states affected by the individual gene modifications and explored how these genes interact and depend on one another. "In the past, functional screens have had to choose between either measuring simple phenotypic changes induced by many perturbations, or taking a rich, high-resolution look at a limited number of perturbations," said Oren Parnas, PhD, co-first author of the Broad-led study, a former postdoctoral researcher at the Broad Institute, and currently a researcher at the School of Medicine of the Hebrew University of Jerusalem. "With Perturb-seq, we can scale up the experiment on both ends." In the UCSF-led experiments, researchers used CRISPR-based transcriptional interference (CRISPRi) to simultaneously repress up to three genes in a cancer cell line and to investigate the unfolded protein response (UPR), a well-known quality control pathway that senses stress in the endoplasmic reticulum (ER), where many of a cell's key proteins are made. The UPR detects errors in cells' protein-production machinery and ensures that impaired cells self-destruct. After identifying hundreds of genes whose functions are monitored by the UPR in a genome-wide CRISPRi screen, the UCSF-led team applied Perturb-seq to interrogate a subset of these genes with single-cell resolution, allowing the researchers to systematically reveal the relationships between the genes and dissect the complex ways in which cells respond to ER stress. "With the unbiased readout we get from single-cell RNA sequencing, we can potentially discover things about biological pathways without a prior hypothesis," said Tom Norman, PhD, co-first author of the UCSF-led study and a postdoctoral researcher in the Weissman lab. "It opens up new possibilities that might not be evident from more targeted studies." The Perturb-seq method can be used to investigate the functional effects of disease-causing alleles, and to explore on a large scale other targets that could be modified to reverse those effects. The approach is also powerful because it allows the study of several perturbations at once, which can inform the search for combination therapies in cancer, for example. "By working together to establish the core technology and then pursuing parallel efforts to evaluate Perturb-seq with CRISPR-based methods to inactivate or repress genes in different areas of biology, our teams were able to quickly show that the system is widely applicable," said Britt Adamson, PhD, co-first author of the UCSF-led study and a postdoctoral researcher in the Weissman lab. "The fact that Perturb-seq is not limited to one type of CRISPR-mediated perturbation should be incredibly enabling and allow other research groups to take advantage of the new method." The researchers say they hope the two Cell studies will serve as robust examples of their new platform, and that as single-cell sequencing technology advances and becomes more powerful and available in the future, Perturb-seq will likely become even easier and faster, enabling increasingly powerful studies that can shed light on genes and their interactions in health and disease. More information: Atray Dixit et al. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens, Cell (2016). DOI: 10.1016/j.cell.2016.11.038 Britt Adamson et al. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response, Cell (2016). DOI: 10.1016/j.cell.2016.11.048

News Article | February 22, 2017
Site: en.prnasia.com

ZHENJIANG, China, Feb. 22, 2017 /PRNewswire/ -- Delta Technology Holdings Limited (NASDAQ: DELT), a manufacturer and seller of specialty chemicals, today announced that it is increasing both the number of core clients it serves and the amount of product sold to these companies. "We are confident that the products we produce for pharmaceutical and pesticide companies, and companies in other sectors including clean energy, food additives, aerospace and agrochemical, allow these major firms to achieve successes. We are very proud of the strategic cooperation these major companies have with Delta Technology," said Chao Xin, Chairman and CEO. Delta Technology services giant international chemical companies including Bayer, BASF Corporation, FMC Corporation as well as several public companies in China listed on the Shenzhen Stock Exchange for example: Jiangsu Flag Chemical Industry Co., Ltd.; Jiangsu Huifeng Agrochemical Co., Ltd., Huapont Life Sciences Co, Ltd. and Jiangsu Changqing Agrochemical Co., Ltd. Founded in 2007, Delta Technology Holdings Ltd. is a leading China-based fine and specialty chemical company producing and distributing organic compound including para-chlorotoluene ("PCT"), ortho-chlorotoluene ("OCT"), PCT/OCT downstream products, unsaturated polyester resin ("UPR"), maleic acid ("MA") and other by-product chemicals. The end application markets of the Company's products include Automotive, Pharmaceutical, Agrochemical, Dye & Pigments, Aerospace, Ceramics, Coating-Printing, Clean Energy and Food Additives. Delta has approximately 300 employees, 25% of whom are highly-qualified experts and technical personnel. The Company serves more than 380 clients in various industries. This press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements are subject to known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Statements preceded or followed by or that otherwise include the words "believes," "expects," "anticipates," "intends," "projects," "estimates," "plans," and similar expressions or future or conditional verbs such as "will", "should", "would", "may" and "could" are generally forward-looking in nature and not historical facts. Forward-looking statements in this release also include statements about business and economic trends. Investors should also consider the areas of risk described under the heading "Forward Looking Statements" and those factors captioned as "Risk Factors" in DELT's periodic reports under the Securities Exchange Act of 1934, as amended, or in connection with any forward-looking statements that may be made by DELT. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/delta-technology-holdings-limited-continues-to-expand-revenues-from-core-client-base-300411535.html

News Article | December 16, 2016
Site: www.eurekalert.org

Antiretroviral drugs have been life-changing therapies for HIV patients, but they can have significant side effects. Mounting evidence has implicated these drugs in contributing to HIV-associated neurocognitive disorders, or HAND, which can be manifested as forgetfulness, confusion and behavioral and motor changes. Yet an explanation for how the drugs take a toll on the brain has been lacking. Researchers from the University of Pennsylvania have now pinpointed some of the key players in causing neuronal damage. Their work suggests that certain protease inhibitors, among the most effective HIV drugs, lead to the production of the peptide beta amyloid, often associated with Alzheimer's disease. The drugs prompt an increase in levels of the enzyme that cleaves the amyloid precursor protein, APP, to produce beta amyloid, which is responsible for the damage to neurons. Notably, inhibiting that enzyme, called BACE1, protected human and rodent brain cells from harm, suggesting that targeting this pathway with a new drug could minimize damage to neurons in patients on antiretroviral therapies. "Protease inhibitors are very effective antiviral therapies, but they do have inherent toxicities," said Kelly Jordan-Sciutto, chair and professor in the Penn School of Dental Medicine's Department of Pathology and senior author on the study. "Our findings may cause us to rethink how we're using these drugs and even consider developing an adjunctive therapy to reduce some of these negative effects." The study appears in the American Journal of Pathology. Protease inhibitors such as ritonavir and saquinavir are a key part of the drug cocktail that has reduced mortality in HIV-infected people by 50 percent. Though newer compounds form the frontline treatments for patients in the United States, these protease inhibitors remain widely used in Africa and other developing areas hit hard by HIV/AIDS. They work by blocking viral enzymes necessary for creating infectious particles that allow the virus to spread through the body. Previous investigations by Jordan-Sciutto's team have suggested, however, that protease inhibitors can have toxic effects on the central nervous system. One study, for example, demonstrated that they triggered the activation of stress-response pathways, including oxidative stress and a process called the unfolded-protein response, or UPR. UPR results when the cell senses misfolded or modified proteins, causing a halt in protein translation. It's meant to protect a cell from aberrant proteins, but, when chronically activated, it can lead to cellular damage or death. Even after these studies, it wasn't clear whether UPR seen in HIV patients was induced primarily as a result of the virus or of the treatment, and what molecules mediated it. In addition, the researchers were intrigued by the findings of colleague and coauthor Robert Vassar of Northwestern University, who showed that stress-induced UPR led to activation of beta-site APP cleaving enzyme 1, or BACE1, an enzyme that snips apart APP to produce beta amyloid. "The study emerged from these three lines of converging evidence," Jordan-Sciutto said. "We knew UPR was activated in HIV patients both on and off antiretroviral therapy; we knew that, despite antiretroviral therapy, cognitive impairment persisted in these patients; and we knew that activation of UPR lead to an increase in BACE1." To determine whether and how neuronal damage arises from drug treatment and to ascertain BACE1's role, the team investigated the effects of protease inhibitors in two animal models, then probed the mechanism of action in cells in culture. First, to confirm that the drugs themselves, and not the underlying HIV infection, were responsible for neuronal damage, they examined a population of macaques, some of which had SIV, a retrovirus very similar to HIV that affects non-human primates. The researchers found that SIV-positive animals that had been treated had increased expression of APP in their neurons, a sign of damage, as well as increased BACE1 compared to the untreated animals. They further confirmed that the drugs were the culprit in causing these changes by administering ritonavir and saquinavir to healthy adult mice. Again, they observed singificant increases in BACE1. Turning to cells in culture, they found that administering ritonavir or saquinavir at doses equivalent to those seen in the blood of treated humans led to dramatic increases in molecular markers associated with UPR as well as increases in BACE1 expression. Furthermore, they demonstrated that the increase in BACE1 led directly to an increase in processing of APP. Applying an inhibitor of BACE1 to rat brain cells in culture prevented the damage that ritonavir treatment otherwise induced. "Putting this together with our earlier findings on oxidative stress, it appears that the drugs are triggering oxidative stress that is damaging proteins and inducing the unfolded protein response," said Cagla Akay Espinoza, a research scientist in Jordan-Sciutto's lab and a coauthor. "The virus itself provides a stress, but the drugs are causing additional stress and damage to neurons, in part by BACE1 leading to downstream processing of amyloid precursor protein." A final set of experiments showed that an enzyme called PERK, a major player in UPR, helped mediate the increase in BACE1 expression in neurons triggered by protease inhibitors. "We're very interested in the role of PERK in this process," said Jordan-Sciutto. "Targeting PERK and/or BACE1 could help contribute to a therapeutic approach to treat drug-associated cognitive disorders." The new findings open up a number of avenues for future research. The team would like to explore whether this pathway of neuronal damage applies to other HIV drugs and how the UPR differs depending on whether the virus or the drugs are inducing it. Also, given the connection between beta amyloid, APP and Alzheimer's disease, the team is curious to learn more about how these peptides contribute to the disorders seen both in that disease and in HAND. In addition to Jordan-Sciutto, Akay Espinoza and Vassar, authors on the work included Penn Dental Medicine's Patrick J. Gannon, Alan C. Yee, Michelle A. Erickson, Nicholas S. Kim, Gabriel Van De Walle and Brigid K. Jensen; R. Chistopher Pierce, Alexander J. Gill and Dennis L. Kolson of Penn's Perelman School of Medicine; Lisa A. Briand of Temple University; Benjamin B. Gelman of the University of Texas Medical Branch; Yan Gao and J. Alan Diehl of the Medical University of South Carolina; and Norman J. Haughey, Joseph L. Mankowski, M. Christine Zink and Janice E. Clements of the Johns Hopkins University School of Medicine. The study was supported by the National Institutes of Health.

News Article | February 21, 2017
Site: www.prnewswire.co.uk

The report "Unsaturated Polyester Resins Market by Type (Orthophthalic, Isophthalic & DCPD), End-Use Industry (Building & Construction, Marine, Land Transportation, Pipes & Tanks, Artificial Stone, Wind Energy, Electrical & Electronics) - Global Forecast to 2021", published by MarketsandMarkets, the market is expected to grow from USD 9.17 Billion in 2016 to USD 12.15 Billion by 2021, at a CAGR of 5.78% between 2016 and 2021. Early buyers will receive 10% customization on this report. Based on end-use industry, the building & construction segment is projected to lead the UPR market during the forecast period Based on end-use industry, the building & construction segment accounted for the largest share of the global UPR market in 2015. UPR are being widely used in the construction sector, as they are utilized in Fiber-Reinforced Plastics (FRP), artificial stones, marbles, granites, and putties, among others. Building & construction is an important end-use industry for UPR, as in emerging economies, substantial investments are being made in the infrastructure sector, which, in turn, is driving the UPR market. Therefore, rapid growth of the building & construction sector in India, China, South Africa, UAE, and Brazil has influenced the growth of the UPR market. Ask for PDF of the Report at http://www.marketsandmarkets.com/pdfdownload.asp?id=891 Based on type, the orthophthalic segment is expected to lead the UPR market during the forecast period Based on type, the orthophthalic segment is estimated to lead the global UPR market in 2016, in terms of value and volume. Orthophthalic have different properties such as high flexibility and tensile strength. Orthophthalic resins are advantageous in terms of cost, toughness, and chemical resistance as compared to other resin types such as isophthalic, DCPD, and terephthalic. These are commonly used in hulls and decks of boats, land transport components, molding, wind blade manufacturing, FRP structures, laminating resins, and in various other applications such as adhesives, buttons, castings, composites, encapsulation, flooring materials, gelcoats, filler pastes, pigment pastes, polymer concrete, putties, tooling, and fire-retardant & anti-corrosion coating. Asia-Pacific expected to lead the UPR market during the forecast period The Asia-Pacific region is expected to lead the UPR Market during the forecast period. In this region, China and India are the biggest consumers of UPR. Key factors driving the UPR market in the Asia-Pacific region are: AOC LLC (U.S.), Ashland Inc. (U.S.), Reichhold Inc. (U.S.), BASF SE (Germany), Royal DSM (Netherlands), Scott Bader (U.K.), and U-Pica Technology Group (Japan), among others, are the key players in the global UPR market. Phthalic Anhydride Market and Derivatives (Plasticizers, Unsaturated Polyester Resins, and Alkyd Resins) by Application & Geography - Trends & Forecast to 2018 http://www.marketsandmarkets.com/Market-Reports/phthalic-anhydride-derivatives-market-179828823.html MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. Our 850 fulltime analyst and SMEs at MarketsandMarkets are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. M&M's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. The new included chapters on Methodology and Benchmarking presented with high quality analytical infographics in our reports gives complete visibility of how the numbers have been arrived and defend the accuracy of the numbers. We at MarketsandMarkets are inspired to help our clients grow by providing apt business insight with our huge market intelligence repository. Contact: Mr. Rohan MarketsandMarkets 701 Pike Street Suite 2175, Seattle, WA 98101, United States Tel: +1-888-600-6441 Email: sales@marketsandmarkets.com Visit MarketsandMarkets Blog @ http://www.marketsandmarketsblog.com/market-reports/chemical Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets

News Article | February 20, 2017
Site: globenewswire.com

IRVING, Texas, Feb. 20, 2017 (GLOBE NEWSWIRE) -- The unsaturated polyester resin industry is a mature market that is predominantly characterized by established products, applications, and processes. The major players offer a complete portfolio of resins, covering all the major chemistries and the property and/or performance requirements for the wide range of application markets and processing methods. This report has 163 figures/charts and 171 tables spread through 208 pages http://www.lucintel.com/unsaturated_polyester_resin_competitive_analysis.aspx Polynt and Ashland are the market leaders with diversified product portfolios, strong geographical reach, and high strategic initiatives. Over the next five years, suppliers will be focusing on growing end-user industries like transportation, pipe & tank, and construction in emerging countries like India, China, and the Middle East (particularly in the UAE and Saudi Arabia) where they are likely to capture larger market share in the global UPR market. Over the last five years, suppliers have focused on new product developments which are resins that are styrene free or have low styrene content. The suppliers have grown organic and inorganic in the last five years. Polynt acquired CCP composites and Reichhold to become the UPR market leader. Also, DSM Composite Resins and CCV have formed a partnership to create a new company: Aliancys A.G. The suppliers have also made partnerships, agreements, and contracts with various distributers around the world. The companies producing UPR are exploring market opportunities with starkly different strategies. Lucintel, a leading global management consulting and market research firm, has analyzed the global UPR market and has come up with a comprehensive research report, “Worldwide Unsaturated Polyester Resin Competitive Analysis and Leadership Study 2016.” This report offers a full competitive analysis from target markets to product mapping, from selling strategies to production capabilities. This report has examined and profiled the world’s leading UPR producers. Lucintel created profiles of each competitor based on the following criteria: Financial Strength The resulting research report represents the most comprehensive strategic and tactical assessment of the UPR producers and competitive landscape available. In terms of the total revenue generated by leading UPR producers, Polynt ranks number one, followed by Ashland. AOC, New Solar Co. Ltd., and Aliancys A. G. (DSM) all of which are included in the report. The detailed analysis of each company offers a critical view into key strategic areas, including: Designed for the composites and non-composites industry professionals, financial services firms, and users of UPR, Lucintel's “Worldwide Unsaturated Polyester Resin Competitive Analysis and Leadership Study 2016” is the industry’s comprehensive examination of the UPR producers’ competitive landscape. Collected from a series of primary vendor interviews and secondary sources, Lucintel also provides its own scorecard for determining which of these companies is better aligned with future market opportunities and which has the ability to gain additional market share. Using its proprietary research methodology, Lucintel has developed a comparative analysis tool, the ‘Lucintel Leadership Quadrant,’ which identifies leaders and challengers in the UPR market and rates each UPR producer on two primary criteria as shown below: Ability to gain market share was analyzed using following parameters: Alignment with market opportunity was analyzed using following parameters: About Lucintel Lucintel, the premier global management consulting and market research firm, creates winning strategies for growth—whether you need to understand market dynamics, identify new opportunities, or increase your profitability. It offers market assessments, competitive analysis, opportunity analysis, growth consulting, M&A and due diligence services to executives and key decision-makers in a variety of industries. Over the last 15 years, Lucintel has served over 1,000 corporations in 70 countries. For further information, visit www.lucintel.com. Connect with us on LinkedIn here https://www.linkedin.com/company/lucintel?trk=top_nav_home

News Article | November 4, 2016
Site: globenewswire.com

IRVING, Texas, Nov. 04, 2016 (GLOBE NEWSWIRE) -- According to a new market report published by Lucintel, the future of the global composites market looks bright, with opportunities in the transportation, construction,   wind energy, pipe and tank, marine, consumer goods, electrical/electronic, aerospace, and others.  The global composites market is expected to reach an estimated $37.3 billion by 2021 and it is forecast to grow at a CAGR of 5.1% from 2016 to 2021. The major drivers of growth for this market are double-digit growth in wind energy and strong growth in aerospace market. Increasing urban population and high growth in the building and infrastructure development are other major drivers. This report has 242 figures/charts and 39 tables spread through 371 pages Lucintel, a leading global management consulting and market research firm, has analyzed the global composites industry and presents its findings in the report “Growth Opportunities in Global Composites Industry 2016-2021.” The Asian region, which has already emerged as the largest growth area for the composites industry, is expected to further consolidate its leadership. Asia is anticipated to have a market share of approximately 47.7% by volume in 2021. North America is expected to be second with an estimated market share of 26.2% in 2021. Nevertheless, comparatively lower levels of per capita composite consumption is anticipated to help high growth markets in BRIC countries sustain momentum for a longer period. On a global basis, the composites industry is forecast to grow by 3.5% in 2016. Improving economic conditions in major countries in North America and in Europe are expected to propel the global composites market once again towards strong growth. Lucintel’s research further reveals that demand for composite materials in the aerospace sector is expected to witness the maximum growth among all sectors. Construction and transportation are anticipated to witness continued strong growth during the forecast period of 2016 to 2021. Carbon fiber composite applications are expected to grow more rapidly compared to glass fiber applications. In the future, Lucintel expects higher market fragmentation for the industry due to the emerging economies coming into play. The future market is expected to be highly competitive, and companies with innovative capabilities are anticipated to thrive and gain market share. Emerging trends, which have a direct impact on the dynamics of the industry, include development of low-cost carbon fibers for automotive, wind, and industrial applications. Development of high performance glass fiber and shorter cycle time of resin system are other emerging trends in composites industry. This report by Lucintel provides a concise overview of the global composites market. The study contains detailed analysis of different raw material use such as glass fiber, carbon fiber, aramid fiber, UPR, epoxy, vinyl ester, phenolic, polyurethane, and thermoplastic resin. The data and analysis found in this report can be utilized for a variety of functional business reasons including business development, strategic planning, business presentations, determination of market size and trend, competitive analysis, investment decisions, business vision, and joint product development. This report is a must-have for every company working in the composites industry. In today’s global economy, you need every advantage that you can find to keep your business ahead by learning about current and future trends, identifying key players, and exploring the directions that the industry and different segments are heading. This unique report from Lucintel will provide you with valuable information, insights, and tools needed to identify new growth opportunities and operate your business successfully in this market. This report will save hundreds of hours of your own personal research time and will significantly benefit you in expanding your business in this market. In today’s stringent economy, you need every advantage that you can find. To make any investment, business or strategic decisions, you need timely and robust market information. This market report fulfills this core need. This is an indispensable reference guide for composite material suppliers, product manufacturers, investors, researchers, engineers, distributors and many more, who are dealing with the composites industry. Pre purchase/ for additional queries please visit here http://www.lucintel.com/composites_market_2021.aspx Some features of “Growth Opportunities in Global Composites Industry 2016-2021” include: The table of content is available here http://www.lucintel.com/composites_market_2021.aspx This 371-page research report will enable you to make confident business decisions in this globally competitive marketplace. For a detailed table of contents, contact Lucintel at +1-972-636-5056 or click on this link http://www.lucintel.com/composites_market_2021.aspx or helpdesk@lucintel.com. Lucintel, the premier global management consulting and market research firm, creates winning strategies for growth. It offers market assessments, competitive analysis, opportunity analysis, growth consulting, M&A, and due diligence services to executives and key decision-makers in a variety of industries. For further information, visit www.lucintel.com.

News Article | December 19, 2016
Site: www.marketwired.com

FINRA Approves Change to Sector 5's Stock Ticker Symbol to (OTCQB: SFIV); UPR is working with S&P Capital IQ, Thomson Reuters, and others to resolve these data inaccuracies for Sector 5 HENDERSON, NV--(Marketwired - Dec 19, 2016) - Universal PR announced today that Data Aggregators were Lagging in Updating Vital Information about Sector 5 on the Top Broker Dealers Trading Platforms utilizing "market intelligence databases," which seems like a contradiction in terms. Sector 5, Inc. ( : SFIV) is addressing investors' concerns that critical company profile updates are not being reflected on trading platforms and market research sites. Data is centralized at the SEC but data aggregators are not meeting the standards for quality, accuracy, and timeliness that are a necessity in Sector 5's marketplace. Various trading platforms and market data research providers have outdated and incorrect information about Sector 5. The Company reiterates that the SEC updated its SIC Code to 3571 Electronic Computers in August 2016. "Many of our press releases and other current information was not updating on many trading platforms, creating confusion and concern in the marketplace," said Roger McKeague, Sector 5's CEO. "After pursuing many avenues to solve this issue, Reuters recommended changing our Stock Ticker Symbol. We also felt that a change to SFIV would more uniquely identify Sector 5, especially as we have expanded our relationship with Google which now includes two approved Chromebooks." About: Sector 5, Inc. ( : SFIV), SIC Code 3571 - Electronic Computers, is a Proud American Corporation, that sells, manufactures and develops new innovative consumer electronics under Sector 5 ® and other brands. The Company markets its Chromebooks to educational organizations, other B2B and B2C sales channels, with retail sales on Amazon. It is in development of several new products to serve the educational, business and retail markets. For more information, please visit www.sector-five.com or follow on Facebook (www.facebook.com/sect5) and Twitter (www.twitter.com/sectorfiveinc). About: Universal PR: UPR IS A LEADING COMMUNICATIONS MARKETING AGENCY. Follow on www.twitter.com/universalprteam and find further information at www.universal-pr.com Certain statements made in this release are "forward-looking statements" regarding the plans and objectives of management for future operations. Such statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. The forward-looking statements included herein are based on current expectations that involve numerous risks and uncertainties. Our plans and objectives are based, in part, on assumptions involving judgments with respect to, among other things, future economic, competitive and market conditions and future business and financial decisions, all of which are difficult or impossible to predict accurately and many of which are beyond our control. Although we believe that our assumptions underlying the forward-looking statements are reasonable, any of the assumptions could prove inaccurate and, therefore, there can be no assurance that the forward-looking statements included in this website will prove to be accurate. In light of the significant uncertainties inherent in the forward-looking statements included herein particularly in view of the current early stage of our operations and lack of sufficient financing, the inclusion of such information should not be regarded as a statement by us or any other person that our objectives and plans will be achieved. Factors that could cause actual results to differ materially from those expressed or implied by such forward-looking statements include, but are not limited to, the risk factors set forth in our periodic reports and other filings we make with the U.S Securities and Exchange Commission. We undertake no obligation to revise or update publicly any forward-looking statements for any reason, except as required by federal securities law.

News Article | February 27, 2017
Site: www.prnewswire.com

NEW YORK, Feb. 27, 2017 /PRNewswire/ -- The global Unsaturated Polyester Resins (UPR) market is projected to reach USD 12.15 billion by 2021, at a CAGR of 5.78% from 2016 to 2021. Growth of this market can be attributed to the expansion of the construction industry, increasing urban...

DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of the "Unsaturated Polyester Resins Market by Type, End-Use Industry - Global Forecast to 2021" report to their offering. The global Unsaturated Polyester Resins (UPR) market is projected to reach USD 12.15 billion by 2021, at a CAGR of 5.78% from 2016 to 2021. Growth of this market can be attributed to the expansion of the construction industry, increasing urban population, recovery of the global economy, and growth of the composite industry. In contrast to this, increase in styrene content and use of epoxy resins act as major restraining factors hampering market growth. Based on end-use industry, the wind energy segment is projected to grow at the highest CAGR from 2016 to 2021, both in terms of value and volume. It is expected to provide a broader range of end-use products manufactured from UPR. Wind blades manufacturing is the major application for UPR. The consumption of power energy is increasing at a rapid pace due to rise in supply of energy across the globe. The depletion of fossil fuels and their volatile prices have resulted in increase in energy cost, as demand is constantly growing. This will necessitate huge investments and developments in power generation and grid infrastructure. The Asia-Pacific region led the global UPR market, in terms of volume, in 2015. China and India are the two major markets in this region. Rapid industrialization in countries such as India, China, Indonesia, and Malaysia coupled with relaxed norms, cheap labor, and wide customer base are attracting leading players to set up their facilities in this region. For more information about this report visit http://www.researchandmarkets.com/research/6txlnc/unsaturated

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