Uppsala, Sweden

Uppsala University

Uppsala, Sweden

Uppsala University is a research university in Uppsala, Sweden, and is the oldest university in Sweden, founded in 1477. It ranks among the best universities in Northern Europe and in international rankings.The university rose to pronounced significance during the rise of Sweden as a great power at the end of the 16th century and was then given a relative financial stability with the large donation of King Gustavus Adolphus in the early 17th century. Uppsala also has an important historical place in Swedish national culture, identity and for the Swedish establishment: in historiography, literature, politics, and music. Many aspects of Swedish academic culture in general, such as the white student cap, originated in Uppsala. It shares some peculiarities, such as the student nation system, with Lund University and the University of Helsinki.Uppsala belongs to the Coimbra Group of European universities. The university has nine faculties distributed over three “disciplinary domains”. It has about 24,000 full-time students and 2,400 doctoral students. It has a teaching staff of roughly 1,800 out of a total of 6,500 employees. Twenty-five per cent of the 674 professors at the university are women. Of its turnover of SEK 5.9 billion in 2013, 30% was spent on education on basic and advanced level, while 66% was spent on research and research programs.Architecturally, Uppsala University has traditionally had a strong presence in the area around the cathedral on the western side of the River Fyris. Despite some more contemporary building developments further away from the centre, Uppsala's historic centre continues to be dominated by the presence of the university. Wikipedia.

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Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-11-2016 | Award Amount: 16.11M | Year: 2017

PRACE, the Partnership for Advanced Computing is the permanent pan-European High Performance Computing service providing world-class systems for world-class science. Systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 11 billion core hours of compute time. HPC experts from 25 member states enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is in transition to PRACE 2, the successor of the initial five year period. The objectives of PRACE-5IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2 including an analysis of Trans National Access; strengthening the internationally recognised PRACE brand; continuing and extend advanced training which so far provided more than 18 800 persontraining days; preparing strategies and best practices towards Exascale computing; coordinating and enhancing the operation of the multi-tier HPC systems and services; and supporting users to exploit massively parallel systems and novel architectures. A high level Service Catalogue is provided. The proven project structure will be used to achieve each of the objectives in 6 dedicated work packages. The activities are designed to increase Europes research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and new communities and special offers to SMEs; implementing a new flexible business model for PRACE 2; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, CoEs and other European and international organisations on future architectures, training, application support and policies. This will be monitored through a set of KPIs.

Evers K.,Uppsala University
Nature Reviews Neuroscience | Year: 2016

Neuroethics research can contribute a level of conceptual clarity to international brain research initiatives that is essential for their ethics management as well as for the interpretations, applications and management of their emerging neuroscientific findings. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Ingelsson M.,Uppsala University
Frontiers in Neuroscience | Year: 2016

Adverse intra- and extracellular effects of toxic a-synuclein are believed to be central to the pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the nervous system. One of the physiological roles of a-synuclein relates to the regulation of neurotransmitter release at the presynapse, although it is still unclear whether this mechanism depends on the action of monomers or smaller oligomers. As for the pathogenicity, accumulating evidence suggest that prefibrillar species, rather than the deposits per se, are responsible for the toxicity in affected cells. In particular, larger oligomers or protofibrils of a-synuclein have been shown to impair protein degradation as well as the function of several organelles, such as the mitochondria and the endoplasmic reticulum. Accumulating evidence further suggest that oligomers/protofibrils may have a toxic effect on the synapse, which may lead to disrupted electrophysiological properties. In addition, recent data indicate that oligomeric a-synuclein species can spread between cells, either as free-floating proteins or via extracellular vesicles, and thereby act as seeds to propagate disease between interconnected brain regions. Taken together, several lines of evidence suggest that a-synuclein have neurotoxic properties and therefore should be an appropriate molecular target for therapeutic intervention in Parkinson's disease and other disorders with Lewy pathology. In this context, immunotherapy with monoclonal antibodies against a-synuclein oligomers/protofibrils should be a particularly attractive treatment option. © 2016 Ingelsson.

Nordstrom K.,Uppsala University
Current Opinion in Neurobiology | Year: 2012

Despite being equipped with low-resolution eyes and tiny brains, many insects show exquisite abilities to detect and pursue targets even in highly textured surrounds. Target tracking behavior is subserved by neurons that are sharply tuned to the motion of small high-contrast targets. These neurons respond robustly to target motion, even against self-generated optic flow. A recent model, supported by neurophysiology, generates target selectivity by being sharply tuned to the unique spatiotemporal profile associated with target motion. Target neurons are likely connected in a complex network where some provide more direct output to behavior, whereas others serve an inter-regulatory role. These interactions may regulate attention and aid in the robust detection of targets in clutter observed in behavior. © 2012 Elsevier Ltd.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-03-2016 | Award Amount: 6.22M | Year: 2017

STARCELL proposes the substitution of CRMs in thin film PV by the development and demonstration of a cost effective solution based on kesterite CZTS (Cu2ZnSn(S,Se)4) materials. Kesterites are only formed by elements abundant in the earth crust with low toxicity offering a secure supply chain and minimizing recycling costs and risks, and are compatible with massive sustainable deployment of electricity production at TeraWatt levels. Optimisation of the kesterite bulk properties together with redesign and optimization of the device interfaces and the cell architecture will be developed for the achievement of a challenging increase in the device efficiency up to 18% at cell level and targeting 16% efficiency at mini-module level, in line with the efficiency targets established at the SET Plan for 2020. These efficiencies will allow initiating the transfer of kesterite based processes to pre-industrial stages. These innovations will give to STARCELL the opportunity to demonstrate CRM free thin film PV devices with manufacturing costs 0.30 /Wp, making first detailed studies on the stability and durability of the kesterite devices under accelerated test analysis conditions and developing suitable recycling processes for efficient re-use of material waste. The project will join for the first time the 3 leading research teams that have achieved the highest efficiencies for kesterite in Europe (EMPA, IMRA and IREC) together with the group of the world record holder David Mitzi (Duke University) and NREL (a reference research centre in renewable energies worldwide) in USA, and AIST (the most renewed Japanese research centre in Energy and Environment) in Japan. These groups have during the last years specialised in different aspects of the solar cell optimisation and build the forefront of kesterite research. The synergies of their joined efforts will allow raising the efficiency of kesterite solar cells and mini-modules to values never attained for this technology.

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